Multiple Sclerosis Clinical Trial
A Study of Suboptimally Controlled Participants Previously Taking Injectable DMDs for RMS (CLICK-MS)
Summary
To evaluate the effectiveness, patient-reported outcomes (PROs) and safety of cladribine tablets in participants with relapsing forms of multiple sclerosis (RMS) including relapsing-remitting multiple sclerosis (RRMS) and active secondary progressive multiple sclerosis (aSPMS),who transition to cladribine tablets after suboptimal response to any injectable disease-modifying drugs (DMDs) approved in the United States (US) for RMS in a real-world setting.
Eligibility Criteria
Inclusion Criteria:
Male or female participants greater than or equal to (>=)18 years
Signed informed consent
Have diagnosis of RMS including RRMS and aSPMS and satisfy the approved indication for cladribine tablets as per United States Prescribing Information (USPI)
Have time since diagnosis of RMS of at least 12 months
Had received their last previous injectable disease-modifying drug (DMD) for at least 3 months
Have decided to initiate treatment with cladribine tablets during routine clinical care
Meet criteria as per the approved USPI
Have access to a valid e-mail address
In the opinion of the Investigator, experienced suboptimal response (lack of effectiveness, intolerability, poor adherence) to injectable DMD treatment
Exclusion Criteria:
Have been previously treated with cladribine in any dosing form
Transitioning from previous injectable DMD solely for administrative reasons such as relocation
Have comorbid conditions that preclude participation
Have any clinical condition or medical history noted as contraindication on USPI
Are currently participating in an interventional clinical trial
Pregnant or breastfeeding women, women who plan to become pregnant or men whose partner plans to become pregnant during the cladribine treatment period
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There are 22 Locations for this study
Little Rock Arkansas, 72205, United States
Englewood Colorado, 80113, United States
Fort Collins Colorado, 80528, United States
Springfield Illinois, 62702, United States
Fort Wayne Indiana, 46804, United States
Overland Park Kansas, 66212, United States
Wellesley Massachusetts, 02481, United States
Worcester Massachusetts, 01655, United States
Detroit Michigan, 48202, United States
Owosso Michigan, 48867, United States
Minneapolis Minnesota, 55422, United States
Las Vegas Nevada, 89128, United States
Charlotte North Carolina, 28203, United States
Greensboro North Carolina, 27405, United States
Philadelphia Pennsylvania, 19140, United States
Round Rock Texas, 78681, United States
San Antonio Texas, 78258, United States
Burlington Vermont, 05401, United States
Christiansburg Virginia, 24073, United States
Richmond Virginia, 23229, United States
Virginia Beach Virginia, 23456, United States
Kirkland Washington, 98034, United States
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