Clinical Applications of Advanced Ophthalmic Imaging

Observational Phase 1 Group

Inclusion Criteria:

Self-reported normal healthy subjects;
Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetics and stroke;
Who can keep the eye open for imaging.

Exclusion Criteria:

who can not read and sign the ICF;
who can not receiving ophthalmic imaging;
who cannot tolerate bright light during imaging.

Interventional Phase 2 Group:

Inclusion criteria

The participant will be eligible for entry in the study if s/he:

Is at least 18 years old and has full legal capacity to volunteer;
Has read and signed the IRB Informed Consent Document;
Is willing and able to follow participant instructions;
Has clear corneas and crystalline lens;
Initial visual acuities were 20/80 or better;
MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease;
Hemoglobin A1c is 10 or less;
Normotensive with or without medications;
Without retinal capillary dropout or macular edema;
Blood homocysteine > 9.

Exclusion criteria

The subjects will be ineligible for entry into the study if s/he:

Has an active ocular disease;
Has had surgery or an eye injury within 6 months.