Multiple Sclerosis Clinical Trial

Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis

Summary

This is a three-week crossover study that will compare how the body absorbs and tolerates two different forms of lipoic acid: R form and racemic form.

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Full Description

This three-week double-blind crossover trial will compare two different forms of lipoic acid (LA). Every participant will take one week of daily oral 600mg R LA, have a one week washout period without LA, and take one week of daily oral 1200mg racemic LA. The order of LA type will be determined by randomization. Blood analyses will be performed to determine which form is better absorbed and a side effects questionnaire will be completed at each visit in order to determine which form is better tolerated.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Diagnosis of Progressive Multiple Sclerosis
18 years of age or older
Able to give informed consent and adhere to the study activities
Able to swallow large oral capsules

Exclusion Criteria:

Clinical Multiple Sclerosis relapse in the prior 1 year
Oral or IV steroids in the prior 3 months
Have taken LA in last 30 days
Clinically significant kidney disease as determined by the PI including, but not limited to, major kidney disease diagnoses, abnormal laboratory values related to renal function, or other related conditions
Insulin-dependent diabetes
Other significant ongoing medical illness that may interfere with study procedures
Taking oral anticoagulants (e.g. Coumadin). Aspirin, clopidogrel, and dipyridamole are acceptable to take
Pregnant or breast-feeding
Any condition which would make the patient, in the opinion of the investigator, unsuitable for the study

Study is for people with:

Multiple Sclerosis

Phase:

Phase 1

Estimated Enrollment:

20

Study ID:

NCT03493841

Recruitment Status:

Completed

Sponsor:

Rebecca Spain

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There is 1 Location for this study

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Oregon Health & Science University
Portland Oregon, 97239, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Sclerosis

Phase:

Phase 1

Estimated Enrollment:

20

Study ID:

NCT03493841

Recruitment Status:

Completed

Sponsor:


Rebecca Spain

How clear is this clinincal trial information?

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