Multiple Sclerosis Clinical Trial
Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)
Summary
Evaluate the safety and efficacy of Siponimod (BAF312) versus placebo in a variable treatment duration in patients with secondary progressive multiple sclerosis (Core Part) followed by extended treatment with open-label BAF312 to obtain data on long-term safety, tolerability and efficacy (Extension Part).
Eligibility Criteria
Inclusion Criteria:
Prior history of relapsing remitting MS
SPMS defined as progressive increase of disability over at least 6 months
EDSS score of 3.0 to 6.5
No relapse of corticosteroid treatment within 3 months
Exclusion Criteria:
Women of child bearing potential must use reliable forms of contraception.
Diagnosis of Macular edema during screening period
Any medically unstable condition determined by investigator.
Unable to undergo MRI scans
Hypersensitivity to any study drugs or drugs of similar class Other protocol defined inclusion/exclusion may apply.
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There are 285 Locations for this study
Phoenix Arizona, 85032, United States
Berkeley California, 94705, United States
Los Angeles California, 90033, United States
Oceanside California, 92056, United States
Sacramento California, 95817, United States
Aurora Colorado, 80045, United States
Basalt Colorado, 81621, United States
Boulder Colorado, 80301, United States
Colorado Springs Colorado, 80907, United States
Englewood Colorado, 80113, United States
Fairfield Connecticut, 06824, United States
Delray Beach Florida, 33445, United States
Jacksonville Florida, 32209, United States
Maitland Florida, 32751, United States
Ormond Beach Florida, 32174, United States
Port Charlotte Florida, 33952, United States
Sunrise Florida, 33351, United States
Tampa Florida, 33609, United States
Tampa Florida, 33612, United States
Vero Beach Florida, 32960, United States
Chicago Illinois, 60612, United States
Evanston Illinois, 60201, United States
Flossmoor Illinois, 60422, United States
Lenexa Kansas, 66212, United States
Baltimore Maryland, 21287, United States
Ann Arbor Michigan, 48109, United States
Detroit Michigan, 48201, United States
Detroit Michigan, 48202, United States
Plymouth Minnesota, 55446, United States
Saint Louis Missouri, 63131, United States
Las Vegas Nevada, 89106, United States
Lebanon New Hampshire, 03756, United States
Freehold New Jersey, 07728, United States
Albuquerque New Mexico, 87131, United States
New York New York, 10017, United States
New York New York, 10029, United States
Patchogue New York, 11772, United States
Stony Brook New York, 11794, United States
Charlotte North Carolina, 28207, United States
Akron Ohio, 44320, United States
Dayton Ohio, 45408, United States
Portland Oregon, 97225, United States
Springfield Oregon, 97477, United States
Philadelphia Pennsylvania, 19104, United States
Providence Rhode Island, 02905, United States
Dallas Texas, 75216, United States
Lubbock Texas, 79410, United States
San Antonio Texas, 78258, United States
Burlington Vermont, 05401, United States
Seattle Washington, 98101, United States
Seattle Washington, 98122, United States
Milwaukee Wisconsin, 53215, United States
Caba Buenos Aires, 1425, Argentina
Caba Buenos Aires, C1181, Argentina
Caba Buenos Aires, C1428, Argentina
Capital Federal Buenos Aires, 1424, Argentina
Buenos Aires , C1424, Argentina
Cordoba , X5000, Argentina
Camperdown New South Wales, 2050, Australia
Kogarah New South Wales, 2217, Australia
Liverpool New South Wales, 2170, Australia
Heidelberg Victoria, 3084, Australia
Parkville Victoria, 3050, Australia
Klagenfurt , 9020, Austria
Vienna , 1090, Austria
Wien , 1010, Austria
Edegem Antwerpen, 2650, Belgium
Brugge , 8000, Belgium
Bruxelles , 1070, Belgium
Fraiture En Condroz , 4557, Belgium
Gent , 9000, Belgium
Leuven , 3000, Belgium
Pelt , 3900, Belgium
Sijsele , 8340, Belgium
Sofia , 1113, Bulgaria
Sofia , 1413, Bulgaria
Sofia , 1431, Bulgaria
Varna , 9010, Bulgaria
Calgary Alberta, T2N 2, Canada
Edmonton Alberta, T6G 2, Canada
Burnaby British Columbia, V5G 2, Canada
Halifax Nova Scotia, B3H 4, Canada
Kingston Ontario, K7L 2, Canada
Ottawa Ontario, K1H 8, Canada
Toronto Ontario, M4N 3, Canada
Greenfield Park Quebec, J4V 2, Canada
Montreal Quebec, H2X 0, Canada
Montreal Quebec, H3A 2, Canada
Beijing Beijing, 10003, China
Beijing Beijing, 10073, China
Changchun Jilin, 13002, China
Taiyuan Shanxi, 03000, China
XI An Shanxi, 71003, China
Chengdu Sichuan, 61004, China
Beijing , 10002, China
Beijing , 10073, China
Shanghai , 20004, China
Brno Czech Rep., 625 0, Czechia
Teplice Czech Republic, 415 0, Czechia
JIhlava , 586 0, Czechia
Prague 5 , 150 0, Czechia
Praha , 12808, Czechia
Tallinn , 10138, Estonia
Tallinn , 10617, Estonia
Nancy Cedex, 54035, France
Bordeaux Cedex , 33076, France
CAEN Cedex , 14033, France
Lille , 59037, France
Marseille Cedex 05 , 13885, France
Montpellier , 34295, France
Nimes , 30029, France
Paris 13 , 75651, France
Rennes , 35043, France
St Herblain , 44800, France
Strasbourg , 67091, France
Regensburg Bavaria, 93053, Germany
Aschaffenburg , 63739, Germany
Bad Mergentheim , 97980, Germany
Bayreuth , 95445, Germany
Berg , 82335, Germany
Berlin , 10713, Germany
Berlin , 13347, Germany
Bielefeld , 33647, Germany
Boblingen , 71032, Germany
Bochum , 44791, Germany
Bonn , 53111, Germany
Dresden , 01307, Germany
Erbach , 64711, Germany
Erlangen , 91054, Germany
Frankfurt , 60313, Germany
Freiburg , 79106, Germany
Hamburg , 20249, Germany
Hamburg , 22083, Germany
Hannover , 30171, Germany
Hannover , 30625, Germany
Heidelberg , 69120, Germany
Homburg , 66421, Germany
Itzehoe , 25524, Germany
Jena , 07740, Germany
Kassel , 34121, Germany
Leipzig , 04103, Germany
Leipzig , 04107, Germany
Muenchen , 80377, Germany
Muenster , 48149, Germany
Neuburg an der Donau , 86633, Germany
Oldenburg , 26122, Germany
Potsdam , 14471, Germany
Prien , 83209, Germany
Rostock , 18057, Germany
Schwendi , 88477, Germany
Siegen , 57076, Germany
Stade , 21682, Germany
Stadtroda , 07646, Germany
Teupitz , 15755, Germany
Ulm , 89073, Germany
Ulm , 89081, Germany
Unterhaching , 82008, Germany
Wiesbaden , 65191, Germany
Athens , 106 7, Greece
Heraklion Crete , 711 1, Greece
Thessaloniki , GR 54, Greece
Budapest HUN, 1135, Hungary
Budapest HUN, 1145, Hungary
Budapest HUN, 1204, Hungary
Esztergom HUN, 2500, Hungary
Balassagyarmat , 2660, Hungary
Budapest , 1085, Hungary
Budapest , 1106, Hungary
Eger , H-330, Hungary
Miskolc , 3526, Hungary
Nyiregyhaza , 4400, Hungary
Veszprem , H 820, Hungary
Dublin 9 D9, D09, Ireland
Dublin 4 , D04 T, Ireland
Jerusalem , 91120, Israel
Ramat Gan , 52621, Israel
Genova GE, 16132, Italy
Milano MI, 20122, Italy
Milano MI, 20132, Italy
Cefalu PA, 90015, Italy
Roma RM, 00133, Italy
Roma RM, 00152, Italy
Roma RM, 00161, Italy
Roma RM, 00168, Italy
Roma RM, 00179, Italy
Napoli , 80131, Italy
Toon-city Ehime, 791-0, Japan
Asahikawa-city Hokkaido, 070-8, Japan
Morioka Iwate, 020-8, Japan
Kyoto-city Kyoto, 616-8, Japan
Suita Osaka, 565 0, Japan
Kawagoe Saitama, 350 8, Japan
Tokorozawa city Saitama, 359 8, Japan
Kodaira Tokyo, 187-8, Japan
Ota-ku Tokyo, 145-0, Japan
Shinjuku ku Tokyo, 162 8, Japan
Shinjuku-ku Tokyo, 160 8, Japan
Aomori , 030 8, Japan
Chiba , 260 8, Japan
Osaka , 556-0, Japan
Riga LV, LV-10, Latvia
Riga , LV 10, Latvia
Riga , LV-10, Latvia
Kaunas LTU, LT 50, Lithuania
Klaipeda , LT-92, Lithuania
Vilnius , LT-08, Lithuania
Breda CK, 4818 , Netherlands
Amsterdam , 1105 , Netherlands
Eindhoven , 5623 , Netherlands
Hoorn , 1624 , Netherlands
Sittard-Geleen , 6162 , Netherlands
Tilburg , 5022 , Netherlands
Grudziadz , 86 30, Poland
Katowice , 40 57, Poland
Kielce , 25 72, Poland
Konskie , 26 20, Poland
Krakow , 31-63, Poland
Lodz , 90 32, Poland
Poznan , 60-35, Poland
Warszawa , 02-95, Poland
Amadora , 2720-, Portugal
Braga , 47102, Portugal
Coimbra , 3000 , Portugal
Lisboa , 16001, Portugal
Porto , 4099-, Portugal
Constanta Jud. Constanta, 90059, Romania
Bucharest , 02012, Romania
Bucharest , 05009, Romania
Suceava , 72752, Romania
Targu Mures , 54013, Romania
Timisoara , 30073, Romania
Barnaul , 65602, Russian Federation
Kazan , 42004, Russian Federation
Moscow , 11904, Russian Federation
Moscow , 12701, Russian Federation
Novosibirsk , 63000, Russian Federation
Saint Petersburg , 19404, Russian Federation
St. Petersburg , 19711, Russian Federation
St. Petersburg , 19737, Russian Federation
Ufa , 45000, Russian Federation
Banska Bystrica , 97517, Slovakia
Bratislava , 813 6, Slovakia
Bratislava , 826 0, Slovakia
Martin , 036 5, Slovakia
Nitra , 94911, Slovakia
Presov , 081 8, Slovakia
Trencin , 91171, Slovakia
Trnava , 917 7, Slovakia
Malaga Andalucia, 29010, Spain
Sevilla Andalucia, 41009, Spain
Hospitalet de Llobregat Barcelona, 08907, Spain
Barcelona Cataluna, 08026, Spain
Badalona Catalunya, 08916, Spain
Barcelona Catalunya, 08003, Spain
Barcelona Catalunya, 08035, Spain
Valencia Comunidad Valenciana, 46010, Spain
Valencia Comunidad Valenciana, 46026, Spain
El Palmar Murcia, 30120, Spain
Bilbao Pais Vasco, 48013, Spain
San Sebastian Pais Vasco, 20080, Spain
Madrid , 28040, Spain
Madrid , 28222, Spain
Goeteborg , 413 4, Sweden
Stockholm , 102 3, Sweden
Stockholm , 10235, Sweden
Aarau CH, 5001, Switzerland
Basel , 4031, Switzerland
Lausanne , 1011, Switzerland
Lugano , 6900, Switzerland
Luzern , 6000, Switzerland
St Gallen , 9007, Switzerland
Zuerich , 8091, Switzerland
Istanbul TUR, 34098, Turkey
Altunizade , 34662, Turkey
Haseki Istanbul , 34096, Turkey
Kocaeli , 41380, Turkey
Mecidiyekoy Istanbul , 34394, Turkey
Samsun , 55139, Turkey
Trabzon , 61080, Turkey
Salford Manchester, M6 8H, United Kingdom
Headington Oxfordshire, OX3 9, United Kingdom
Sheffield South Yorkshire, S10 2, United Kingdom
Bristol , BS10 , United Kingdom
Glasgow , G51 4, United Kingdom
Leeds , LS1 3, United Kingdom
Leicester , LE5 4, United Kingdom
London , EC1A , United Kingdom
London , W8 6R, United Kingdom
Newcastle Upon Tyne , NE1 4, United Kingdom
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