Validation of Hand Held Dynamometer for Assessment of Lower Limb Muscle Strength in Multiple Sclerosis

Inclusion Criteria:

Stable patients with clinically definite Multiple Sclerosis
No Multiple Sclerosis exacerbation 30 days prior to screening
No change in disease modifying therapy for 30 day prior to screening

Exclusion Criteria:

Inflammatory myopathy
Endocarditis, pericarditis o rother unstable heart disease
Cardiac surgery or myocardial infarction in the last 3 months
Decompensated congestive heart failure
Severe aortic stenosis
Severe pulmonary hypertension
Pulmonary embolus or infarction in the last 6 months
Uncontrolled hypertension by history or by screening or baseline diastolic blood pressure >170 or systolic blood pressure >105
Concomitant neurodegenerative neurological disease such as Amyotrophic Lateral Sclerosis (ALS) Parkinsons or hemiplegic stroke
females who are pregnant
Cognitive deficits that would interfere with the subjects's ability to give informed consent or preform study testing
Painful orthopedic condition affecting the lower limbs
Any other serious and/or unstable medical condition