Myeloproliferative Neoplasms Clinical Trial
Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting
Summary
The purpose of this study is to better understand the use of tyrosine kinase inhibitors (TKI) in patients newly diagnosed with leukemia-cml/" >CML and their quality of life in a real-world setting.
Full Description
Time Perspective : Most patients are expected to be a mix of retrospective and prospective data collection. Patients can be enrolled after their study index date (retrospective component) and have to be followed until 5 years from study index date are complete (time between enrollment and 5 year follow-up is the prospective component)
Eligibility Criteria
Inclusion Criteria:
Newly-diagnosed chronic phase chronic myeloid leukemia (CP-CML) patients who started their first-line Tyrosine Kinase Inhibitor (TKI) treatment on imatinib, dasatinib or nilotinib in accordance with the timelines below
18 years or older at time of of CP-CML diagnosis
a) Imatinib Cohorts
Patients who started their first-line Imatinib treatment between January 2, 2008 and September 30, 2010.Patients fitting this criterion are defined as retrospective Imatinib patients
Patients who started their first-line Imatinib treatment on or after October 1, 2010
b) Dasatinib Cohort
Patients who started their first-line Dasatinib treatment after the drug was approved in this indication
c) Nilotinib Cohort
Patients who started their first-line Nilotinib treatment after the drug was approved in this indication
Patients are also eligible when they have already switched to a subsequent therapy (TKI or other) at the time of enrollment, as long as their first-line and subsequent CML treatment information is available at site for data entry into the study Electronic Case Report Form (eCRF)
Receiving treatment at medical practice (eg. community-based, office-based, hospital-based, academic setting, oncology center)
Exclusion Criteria:
Patients who are participating in an interventional trial which may influence the management of their CML disease will be excluded
Discontinuation Criteria:
Enrolled patients who join an interventional trial which may influence the management of their CML disease will be excluded at the time of entry into the interventional trial
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There are 206 Locations for this study
Muscle Shoals Alabama, 35661, United States
Phoenix Arizona, 85016, United States
Sedona Arizona, 86336, United States
Tucson Arizona, 85704, United States
Hot Springs National Park Arkansas, 71913, United States
Jonesboro Arkansas, 72401, United States
Little Rock Arkansas, 72205, United States
Anaheim California, 92801, United States
Escondido California, 92025, United States
Glendora California, 91741, United States
Los Angeles California, 90033, United States
Orange California, 92868, United States
Oxnard California, 93030, United States
Stockton California, 95204, United States
Truckee California, 96160, United States
Boulder Colorado, 80303, United States
Manchester Connecticut, 06040, United States
Stamford Connecticut, 06904, United States
Washington District of Columbia, 20010, United States
Washington District of Columbia, 20237, United States
Boynton Beach Florida, 33435, United States
Fort Lauderdale Florida, 33308, United States
Hialeah Florida, 33012, United States
Jacksonville Florida, 32207, United States
Jacksonville Florida, 32209, United States
Lakeland Florida, 33805, United States
Leesburg Florida, 34748, United States
Miami Florida, , United States
New Port Richey Florida, 34655, United States
Orlando Florida, 32806, United States
Tavares Florida, 32778, United States
Titusville Florida, 32796, United States
Atlanta Georgia, 30318, United States
Atlanta Georgia, 30322, United States
Marietta Georgia, 30060, United States
Sandy Springs Georgia, 30342, United States
Thomasville Georgia, 31792, United States
Honolulu Hawaii, 96813, United States
Honolulu Hawaii, 96813, United States
Honolulu Hawaii, 96819, United States
Evergreen Park Illinois, 60805, United States
Geneva Illinois, 60134, United States
Normal Illinois, 61761, United States
North Chicago Illinois, 60064, United States
Springfield Illinois, 62794, United States
Urbana Illinois, 61801, United States
Winfield Illinois, 60190, United States
Anderson Indiana, 46016, United States
Indianapolis Indiana, 46237, United States
Indianapolis Indiana, 46260, United States
Lafayette Indiana, 47905, United States
New Albany Indiana, 47150, United States
Mason City Iowa, 50401, United States
Hutchinson Kansas, 67502, United States
Topeka Kansas, 66606, United States
Wichita Kansas, 67214, United States
Lexington Kentucky, 40503, United States
Louisville Kentucky, 40202, United States
Saint Matthews Kentucky, 40207, United States
New Orleans Louisiana, 70121, United States
Shreveport Louisiana, 71103, United States
Columbia Maryland, 21044, United States
Frederick Maryland, 21701, United States
Attleboro Massachusetts, 02703, United States
Boston Massachusetts, 02130, United States
Fall River Massachusetts, 02720, United States
Quincy Massachusetts, 02169, United States
Worcester Massachusetts, 01655, United States
Grand Rapids Michigan, 49503, United States
Kalamazoo Michigan, 49007, United States
Lansing Michigan, 48910, United States
Tupelo Mississippi, 38801, United States
Springfield Missouri, 65807, United States
Billings Montana, 59101, United States
Omaha Nebraska, 68105, United States
Portsmouth New Hampshire, 03801, United States
Does Not Exist New Jersey, 08690, United States
Hackensack New Jersey, 07601, United States
Morristown New Jersey, 07962, United States
Vineland New Jersey, 08360, United States
Bronx New York, 10467, United States
Johnson City New York, 13790, United States
New York New York, 10013, United States
New York New York, 10019, United States
Poughkeepsie New York, 12601, United States
Stony Brook New York, 11794, United States
Burlington North Carolina, 27215, United States
Cary North Carolina, 27518, United States
Durham North Carolina, 27710, United States
Gastonia North Carolina, 28054, United States
Greenville North Carolina, 27834, United States
Akron Ohio, 44302, United States
Canton Ohio, 44718, United States
Middletown Ohio, 45042, United States
Newark Ohio, 43055, United States
Tulsa Oklahoma, 74136, United States
Portland Oregon, 97239, United States
Salem Oregon, 97301, United States
Allentown Pennsylvania, 18103, United States
Bethlehem Pennsylvania, 18015, United States
Kingston Pennsylvania, 18704, United States
Lancaster Pennsylvania, 17601, United States
Pittsburgh Pennsylvania, 15240, United States
West Reading Pennsylvania, 19611, United States
Wilkes-Barre Pennsylvania, 18711, United States
York Pennsylvania, 17403, United States
Cranston Rhode Island, 02920, United States
Pawtucket Rhode Island, 02860, United States
Charleston South Carolina, 29406, United States
Sioux Falls South Dakota, 57105, United States
Watertown South Dakota, 57201, United States
Knoxville Tennessee, 37909, United States
Knoxville Tennessee, 37920, United States
Amarillo Texas, 79106, United States
Arlington Texas, 76014, United States
Austin Texas, 78758, United States
Beaumont Texas, 77701, United States
Dallas Texas, 75230, United States
Dallas Texas, 75231, United States
Dallas Texas, 75237, United States
Houston Texas, 77030, United States
Houston Texas, 77030, United States
Lewisville Texas, 75067, United States
McAllen Texas, 78503, United States
Mesquite Texas, 75150, United States
Midland Texas, 79701, United States
Odessa Texas, 79761, United States
Paris Texas, 75460, United States
Plano Texas, 75075, United States
San Antonio Texas, 78217, United States
Waco Texas, 76712, United States
Danville Virginia, 24541, United States
Fredericksburg Virginia, 22408, United States
Newport News Virginia, 23601, United States
Roanoke Virginia, 24014, United States
Bellevue Washington, 98005, United States
Spokane Washington, 99208, United States
Wenatchee Washington, 98801, United States
Yakima Washington, 98902, United States
Charleston West Virginia, 25304, United States
Martinsburg West Virginia, 25401, United States
Wheeling West Virginia, 26003, United States
Wausau Wisconsin, 53792, United States
Blois cedex , 41016, France
Bordeaux , 33300, France
Chalon/Saone Cedex , 71100, France
Chambéry , 73011, France
Le Mans Cedex 09 , 72037, France
Pierre Benite , 69495, France
PRINGY cedex , 74374, France
Amberg , 92224, Germany
Aschaffenburg , , Germany
Baden-Baden , , Germany
Bamberg , 96049, Germany
Berlin , 12203, Germany
Berlin , 13353, Germany
Bonn , 53105, Germany
Bottrop , 46236, Germany
Coburg , 96450, Germany
Darmstadt , 64283, Germany
Essen , 45136, Germany
Frankfurt am Main , , Germany
Frankurt am Main , 60389, Germany
Greifswald , 17475, Germany
Hamm , 59063, Germany
Hof , 95028, Germany
Idar-Oberstein , 55743, Germany
Kaiserslautern , , Germany
Kassel , 34117, Germany
Koblenz , 56068, Germany
Köln , 50674, Germany
Köln , 50677, Germany
Landshut , 84028, Germany
Lebach , 66822, Germany
Leipzig , 04103, Germany
Mülheim A. D. Ruhr , 45468, Germany
Offenbach , , Germany
Potsdam , 14467, Germany
Rostock , 18057, Germany
Rötha , 04571, Germany
Singen , 78224, Germany
Soest , 59494, Germany
Ulm , 89081, Germany
Velbert , 42551, Germany
Weiden , 92637, Germany
Würzburg , 97080, Germany
Bari , 70124, Italy
Brescia , 25123, Italy
Brindisi , 72100, Italy
Catania , 95124, Italy
Florence , 50134, Italy
Milano , 20162, Italy
Milan , 20122, Italy
Modena , 44100, Italy
Monza , 20052, Italy
Pavia , 27100, Italy
Perugia , 06156, Italy
Pesaro , 61122, Italy
Rionero in Vulture , 85028, Italy
Roma , 00189, Italy
Rome , 00161, Italy
Rome , 00168, Italy
Siena , 53100, Italy
Terni , 05100, Italy
Udine , 33100, Italy
Hoofddorp , 2134 , Netherlands
Bayamon , 00961, Puerto Rico
Saint-Petersburg , 19702, Russian Federation
La Coruña , 15006, Spain
Oviedo - Asturias , 33006, Spain
Pamplona , 31008, Spain
Salamanca , 37007, Spain
Santiago De Compostela-A Coruña , 15706, Spain
Toledo , 45004, Spain
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