Non Hodgkin Lymphoma Clinical Trial
A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma
Summary
This open-label, randomized, 2-arm, multicenter, phase 3 study has the primary objective of comparing the modified progression-free survival (mPFS) obtained with brentuximab vedotin (ADCETRIS®) plus AVD (doxorubicin [Adriamycin], vinblastine, and dacarbazine; abbreviated A+AVD) versus that obtained with ABVD (doxorubicin [Adriamycin],bleomycin, vinblastine, and dacarbazine) for the frontline treatment of advanced classical Hodgkin lymphoma(HL)
Eligibility Criteria
Inclusion Criteria:
Treatment-naïve participants with Ann Arbor Stage III or IV HL.
Histologically confirmed classical Hodgkin Lymphoma (HL) according to the current World Health Organization (WHO) classification.
Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to (<=) 2.
Bidimensional measurable disease as documented by radiographic technique per the International Working Group Revised Criteria for Response Assessment for Malignant Lymphoma.
Exclusion Criteria:
Nodular lymphocyte predominant Hodgkin lymphoma.
Cerebral/meningeal disease, including signs and symptoms of progressive multifocalleukoencephalopathy (PML).
Sensory or motor peripheral neuropathy.
Prior immunosuppressive chemotherapy, therapeutic radiation, or any immunotherapy within 12 weeks of first study drug dose.
Known human immunodeficiency virus (HIV) positive.
Known hepatitis B surface antigen-positive, or known or suspected active hepatitis C infection.
Please note that there are additional exclusion criteria. The study center will determine if you meet all of the criteria.
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There is 1 Location for this study
Birmingham Alabama, , United States
Gilbert Arizona, , United States
Tucson Arizona, , United States
Burbank California, , United States
Duarte California, , United States
Fresno California, , United States
Fullerton California, , United States
La Jolla California, , United States
Long Beach California, , United States
Los Angeles California, , United States
Sacramento California, , United States
San Luis Obispo California, , United States
Santa Barbara California, , United States
Santa Monica California, , United States
Stanford California, , United States
Colorado Springs Colorado, , United States
Denver Colorado, , United States
Lonetree Colorado, , United States
Washington District of Columbia, , United States
Fort Myers Florida, , United States
Jacksonville Florida, , United States
Miami Florida, , United States
Orlando Florida, , United States
Lawrenceville Georgia, , United States
Chicago Illinois, , United States
Maywood Illinois, , United States
Niles Illinois, , United States
Zion Illinois, , United States
Fort Wayne Indiana, , United States
Goshen Indiana, , United States
Indianapolis Indiana, , United States
Iowa City Iowa, , United States
Fairway Kansas, , United States
Baltimore Maryland, , United States
Bethesda Maryland, , United States
Boston Massachusetts, , United States
Ann Arbor Michigan, , United States
Detroit Michigan, , United States
Minneapolis Minnesota, , United States
Rochester Minnesota, , United States
Saint Louis Missouri, , United States
Springfield Missouri, , United States
Lincoln Nebraska, , United States
Omaha Nebraska, , United States
Las Vegas Nevada, , United States
Basking Ridge New Jersey, , United States
Hackensack New Jersey, , United States
Morristown New Jersey, , United States
Albuquerque New Mexico, , United States
Albany New York, , United States
Bronx New York, , United States
Commack New York, , United States
New York New York, , United States
Rochester New York, , United States
Rockville Centre New York, , United States
Charlotte North Carolina, , United States
Raleigh North Carolina, , United States
Bismarck North Dakota, , United States
Cincinnati Ohio, , United States
Columbus Ohio, , United States
Oklahoma City Oklahoma, , United States
Eugene Oregon, , United States
Hershey Pennsylvania, , United States
Philadelphia Pennsylvania, , United States
Charleston South Carolina, , United States
Greenville South Carolina, , United States
Chattanooga Tennessee, , United States
Knoxville Tennessee, , United States
Nashville Tennessee, , United States
Austin Texas, , United States
Dallas Texas, , United States
Houston Texas, , United States
San Antonio Texas, , United States
Tyler Texas, , United States
Salt Lake City Utah, , United States
Fairfax Virginia, , United States
Richmond Virginia, , United States
Kennewick Washington, , United States
Seattle Washington, , United States
Vancouver Washington, , United States
Yakima Washington, , United States
Morgantown West Virginia, , United States
Milwaukee Wisconsin, , United States
Kingswood New South Wales, , Australia
St Leonards New South Wales, , Australia
Westmead New South Wales, , Australia
South Brisbane Queensland, , Australia
Bedford Park South Australia, , Australia
Hobart Tasmania, , Australia
East Melbourne Victoria, , Australia
Geelong Victoria, , Australia
Heidelberg Victoria, , Australia
Parkville Victoria, , Australia
Perth Western Australia, , Australia
Antwerpen , , Belgium
Brugge , , Belgium
Gent , , Belgium
Salvador Bahia, , Brazil
Curitiba Parana, , Brazil
Porto Alegre Rio Grande Do Sul, , Brazil
Santo Andre Sao Paulo, , Brazil
Rio De Janeiro , , Brazil
Sao paulo , , Brazil
Edmonton Alberta, , Canada
Vancouver British Columbia, , Canada
Winnipeg Manitoba, , Canada
Halifax Nova Scotia, , Canada
Toronto Ontario, , Canada
Montreal Quebec, , Canada
Saskatoon Saskatchewan, , Canada
Hradec Kralove , , Czechia
Prague , , Czechia
Praha 10 , , Czechia
Aalborg , , Denmark
Aarhus C , , Denmark
Copenhagen , , Denmark
Odense C , , Denmark
Roskilde , , Denmark
Argenteuil Cedex, , France
La Tronche , , France
Limoges , , France
Paris , , France
Lai Chi Kok Kowloon, , Hong Kong
Hong Kong , , Hong Kong
Tuen Mun , , Hong Kong
Budapest , , Hungary
Debrecen , , Hungary
Gyor , , Hungary
Pecs , , Hungary
Szeged , , Hungary
Modena Emilia-Romagna, , Italy
Roma Lazio, , Italy
Alessandria , , Italy
Bologna , , Italy
Cagliari , , Italy
Cuneo , , Italy
Genova , , Italy
Milano , , Italy
Napoli , , Italy
Rionero In Volture , , Italy
Rome , , Italy
Rozzano , , Italy
Torrette Di Ancona , , Italy
Minami-ku Fukuoka-city, , Japan
Higashi-ku Fukuoka, , Japan
Minami-ku Hiroshima-city, , Japan
Showamachi Maebashi-city, , Japan
Chikusa-ku Nagoya, , Japan
Suita Osaka Prefecture, , Japan
Aoba-ku Sendai-city, , Japan
Chuo-ku , , Japan
Isehara-shi , , Japan
Koto-ku , , Japan
Goyang Gyeonggi, , Korea, Republic of
Hwasun-gun Jeollanam-do, , Korea, Republic of
Seocho-gu Seoul, , Korea, Republic of
Busan , , Korea, Republic of
Daegu , , Korea, Republic of
Incheon , , Korea, Republic of
Jeonju , , Korea, Republic of
Seoul , , Korea, Republic of
Bergen , , Norway
Oslo , , Norway
Gdansk , , Poland
Katowice , , Poland
Krakow , , Poland
L0dz , , Poland
Olsztyn , , Poland
Warszawa , , Poland
Wroclaw , , Poland
Saint-Petersburg Poselok Pesochny, , Russian Federation
Ufa Republic Of Bashkortostan, , Russian Federation
Kazan Republic Tatrstan, , Russian Federation
Moscow , , Russian Federation
Moskva , , Russian Federation
St.Petersburg , , Russian Federation
Johannesburg Gauteng, , South Africa
Pretoria Gauteng, , South Africa
Amanzimtoti Kwa Zulu Natal, , South Africa
Bloemfontein , , South Africa
Cape Town , , South Africa
Badalona , , Spain
Barcelona , , Spain
Marbella , , Spain
Pamplona , , Spain
Salamanca , , Spain
Santiago de Compostela , , Spain
Valencia , , Spain
Changhua City , , Taiwan
Chiayi County 613 , , Taiwan
Tainan , , Taiwan
Taipei , , Taiwan
Taoyuan County , , Taiwan
Ankara , , Turkey
Istanbul , , Turkey
Samsun , , Turkey
Truro Cornwall, , United Kingdom
Aberdeen Scotland, , United Kingdom
Glasgow Scotland, , United Kingdom
Sutton Surrey, , United Kingdom
Cardiff Wales, , United Kingdom
Birmingham , , United Kingdom
Canterbury , , United Kingdom
Exeter , , United Kingdom
Inverness , , United Kingdom
Leicester , , United Kingdom
Lincoln , , United Kingdom
Liverpool , , United Kingdom
London , , United Kingdom
Manchester , , United Kingdom
Norfolk , , United Kingdom
Northwood , , United Kingdom
Nottingham , , United Kingdom
Oxford , , United Kingdom
Romford , , United Kingdom
Southampton , , United Kingdom
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