Non Hodgkin Lymphoma Clinical Trial
A Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma
Summary
This is an open-label, multicenter, phase 2 clinical trial to evaluate the efficacy and safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of brentuximab vedotin in combination with rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of CD30 expression and response in DLBCL (Part C).
Eligibility Criteria
Inclusion Criteria:
Histologically-confirmed NHL (DLBCL only for Parts B and C)
Relapsed or refractory disease following at least 1 prior systemic therapy
Measurable disease of at least 1.5 cm as documented by CT
Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2
Exclusion Criteria:
History of another primary invasive malignancy that has not been in remission for at least 3 years
Current diagnosis of systemic or cutaneous anaplastic large cell lymphoma or mycosis fungoides
B cell lymphoma previously treated with only single-agent rituximab (for patients receiving brentuximab vedotin only) or corticosteroids as monotherapy
Known cerebral/meningeal disease
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There are 34 Locations for this study
Birmingham Alabama, 35294, United States
Duarte California, 91010, United States
Oxnard California, 93030, United States
Stanford California, 94305, United States
Aurora Colorado, 80012, United States
Denver Colorado, 80218, United States
St. Augustine Florida, 32086, United States
Atlanta Georgia, 30322, United States
Chicago Illinois, 60611, United States
Chicago Illinois, 60637, United States
Boston Massachusetts, 02215, United States
Minneapolis Minnesota, 55404, United States
St. Louis Missouri, 63110, United States
Las Vegas Nevada, 89169, United States
Hackensack New Jersey, 07601, United States
Albany New York, 12206, United States
New York New York, 10016, United States
New York New York, 10019, United States
New York New York, 10021, United States
Cleveland Ohio, 44195, United States
Eugene Oregon, 97401, United States
Charleston South Carolina, 29425, United States
Greenville South Carolina, 29605, United States
Dallas Texas, 75230, United States
Dallas Texas, 75246, United States
Fort Worth Texas, 76132, United States
Houston Texas, 77030, United States
Round Rock Texas, 78665, United States
Tyler Texas, 75702, United States
Fairfax Virginia, 22031, United States
Edmonds Washington, 98026, United States
Seattle Washington, 98109, United States
Vancouver Washington, 98684, United States
Vancouver British Columbia, V5Z 4, Canada
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