Non Hodgkin Lymphoma Clinical Trial

A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin’s Lymphoma (cHL), Relapsed or Refractory From First Line Treatment

Summary

The purpose of this study is to determine whether nivolumab plus brentuximab vedotin (followed by brentuximab vedotin plus bendamustine in patient with suboptimal response) is safe and effective in treating patients with Hodgkin's lymphoma (cHL). Eligible patients are children, adolescents, and young adults relapsed or refractory to first line.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Classic Hodgkin Lymphoma (cHL), relapsed or refractory
Minimal limitation on activities of daily living as measured by Karnofsky ≥ 50 for participants > 16 years of age or Lansky ≥ 50 for participants ≤ 16 years of age.
One prior anti-cancer therapy that did not work

Exclusion Criteria:

Active, known, or suspected autoimmune disease or infection
Active cerebral/meningeal disease related to the underlying malignancy
More than one line of anti-cancer therapy or no treatment at all
Received a stem cell transplant for Hodgkin Lymphoma and/or a solid organ transplant
Prior treatment with any drug that targets T cell co-stimulation pathways (such as checkpoint inhibitors)

Other protocol defined inclusion/exclusion criteria apply

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 2

Estimated Enrollment:

72

Study ID:

NCT02927769

Recruitment Status:

Active, not recruiting

Sponsor:

Bristol-Myers Squibb

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There are 79 Locations for this study

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Children's Hospital of Alabama
Birmingham Alabama, 35233, United States
Phoenix Children'S Hospital
Phoenix Arizona, 85016, United States
Loma Linda University Cancer Center
Loma Linda California, 92350, United States
Valley Children's Hospital
Madera California, 93636, United States
Children'S Hospital & Research Center At Oakland
Oakland California, 94609, United States
Children'S Hospital Of Orange County
Orange California, 92868, United States
Lucile Packard Children'S Research Hospital/Stanford Univ
Palo Alto California, 94304, United States
Local Institution - 0091
San Diego California, 92109, United States
Childrens Hospital of Colorado
Aurora Colorado, 80045, United States
Smilow Cancer Hospital At Yale New Haven Hospital
New Haven Connecticut, 06520, United States
Nemours / A. I. duPont Hospital for Children
Wilmington Delaware, 19803, United States
Children'S National Medical Center
Washington District of Columbia, 20010, United States
Nemours Children'S Clinic
Jacksonville Florida, 32207, United States
Local Institution - 0069
Saint Petersburg Florida, 33701, United States
Children's Healthcare Of Atlanta
Atlanta Georgia, 30322, United States
University Of Iowa
Iowa City Iowa, 52242, United States
Local Institution - 0070
Baltimore Maryland, 21287, United States
Dana Farber Cancer Institute.
Boston Massachusetts, 02215, United States
Local Institution - 0097
Detroit Michigan, 48201, United States
University Of Mississippi Medical Center
Jackson Mississippi, 39216, United States
Children'S Mercy Hospital And Clinics
Kansas City Missouri, 64108, United States
Washington University School Of Medicine
Saint Louis Missouri, 63110, United States
Nevada Cancer Research Foundation
Las Vegas Nevada, 89135, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Rutgers Cancer Institute of New Jersey
New Brunswick New Jersey, 08903, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
Local Institution
Chapel Hill North Carolina, 27599, United States
Carolinas Medical Center
Charlotte North Carolina, 28203, United States
Cincinnati Children'S Hospital Medical Center
Cincinnati Ohio, 45229, United States
Nationwide Children'S Hospital
Columbus Ohio, 43205, United States
University Of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States
Local Institution - 0090
Hershey Pennsylvania, 17033, United States
Childrens Hospital Of Philadelphia
Philadelphia Pennsylvania, 19104, United States
Childrens Hospital Of Pittsburgh Of Upmc
Pittsburgh Pennsylvania, 15224, United States
Vanderbilt University
Nashville Tennessee, 37232, United States
Dell Children'S Medical Center Of Central Texas
Austin Texas, 78723, United States
Local Institution - 0071
Dallas Texas, 75235, United States
Baylor College Of Medicine
Houston Texas, 77030, United States
Primary Children's Hospital
Salt Lake City Utah, 84113, United States
Children'S Hosp-Kings Daughter
Norfolk Virginia, 23507, United States
Virginia Commonwealth University
Richmond Virginia, 23219, United States
Local Institution - 0048
Seattle Washington, 98105, United States
Children'S Hospital Of Wisconsin
Milwaukee Wisconsin, 53226, United States
Local Institution
Calgary Alberta, T3B 6, Canada
Local Institution
Toronto Ontario, M5G 1, Canada
The Montreal Children's Hospital of the MUHC
Montreal Quebec, H4A 3, Canada
Klinika detske hematologie a onkologie
Praha 5 , 150 0, Czechia
Local Institution - 0034
Vandoeuvre lès Nancy Meurthe-et-Moselle, 54511, France
Hôpital Jeanne de Flandre
Lille , 59037, France
CHU Lyon GH Est
Lyon Cedex 08 , 69008, France
Local Institution - 0032
Marseille , 13011, France
Local Institution
Nantes , 44093, France
Local Institution - 0031
Paris Cedex 12 , 75571, France
Hopital Robert Debre
Paris , 75019, France
CHU de Toulouse - Hopital des Enfants
Toulouse cedex 9 , 31059, France
Institut Gustave Roussy
Villejuif Cedex , 94805, France
Local Institution - 0056
Berlin , 13353, Germany
Local Institution - 0055
Giessen , 35392, Germany
Mhh Kinderklinik
Hannover , 30625, Germany
Local Institution - 0102
Muenchen , 80337, Germany
Local Institution - 0017
Dublin , Dubli, Ireland
Local Institution - 0024
Aviano (PN) , 33081, Italy
Local Institution - 0020
Bologna , 40138, Italy
Local Institution - 0021
Genova , 16147, Italy
Local Institution - 0019
Monza (mb) , 20900, Italy
Ao Santobono - Pausilipon
Napoli , 80123, Italy
Local Institution - 0022
Roma , 00161, Italy
Local Institution
Rotterdam , 3015 , Netherlands
Local Institution - 0006
Utrecht , 3584 , Netherlands
Local Institution
Gdansk , 80-95, Poland
Local Institution
Krakow , 30-66, Poland
Local Institution - 0082
Barcelona , 08950, Spain
Local Institution
Madrid , 28009, Spain
Local Institution
Leeds North Yorkshire, LS1 3, United Kingdom
Local Institution
Leeds Yorkshire, LS9 7, United Kingdom
Local Institution
Birmingham , B15 2, United Kingdom
Local Institution
Glasgow , G51 4, United Kingdom
Local Institution - 0002
London , NW1 2, United Kingdom
Local Institution - 0012
Manchester , M13 9, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 2

Estimated Enrollment:

72

Study ID:

NCT02927769

Recruitment Status:

Active, not recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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