Non Hodgkin Lymphoma Clinical Trial
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Summary
The purpose of the study is to compare the efficacy of zanubrutinib plus rituximab versus lenalidomide plus rituximab in participants with relapsed/refractory marginal zone lymphoma (R/R MZL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria.
Eligibility Criteria
Key Inclusion Criteria:
Histologically confirmed grade 1-3a FL or MZL
Previously received ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
Need for systemic therapy for FL or MZL
Measurable disease by computed tomography or magnetic resonance imaging
Adequate bone marrow, liver and renal function
Key Exclusion Criteria:
Transformation to aggressive lymphoma
Requiring ongoing need for corticosteroid treatment
Clinically significant cardiovascular disease
Prior malignancy within the past 2 years
Active fungal, bacterial, and/or viral infection that requires systemic therapy
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
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There are 71 Locations for this study
Irvine California, 92618, United States
Los Angeles California, 90067, United States
Jacksonville Florida, 32207, United States
Marietta Georgia, 30060, United States
Fort Wayne Indiana, 46804, United States
Des Moines Iowa, 50309, United States
Topeka Kansas, 66606, United States
Hattiesburg Mississippi, 39401, United States
Springfield Missouri, 65807, United States
Florham Park New Jersey, 07932, United States
Westbury New York, 11590, United States
York Pennsylvania, 17403, United States
Houston Texas, 77030, United States
Concord New South Wales, 2139, Australia
Gosford New South Wales, 2250, Australia
Kogarah New South Wales, 2217, Australia
Orange New South Wales, 2800, Australia
Port Macquarie New South Wales, 2444, Australia
Westmead New South Wales, 2145, Australia
Birtinya Queensland, 4575, Australia
Douglas Queensland, 4814, Australia
Clayton Victoria, 3168, Australia
Fitzroy Victoria, 3065, Australia
Heidelberg Victoria, 3084, Australia
Malvern Victoria, 3144, Australia
Melbourne Victoria, 3002, Australia
Melbourne Victoria, 3004, Australia
West Perth Western Australia, 6005, Australia
Melbourne , 3844, Australia
Florianopolis , 88020, Brazil
Porto Alegre , 90850, Brazil
Beijing Beijing, 10014, China
Chongqing Chongqing, 40003, China
Wuxi Jiangsu, 21402, China
Hradec Kralove , 50005, Czechia
Antony , 92160, France
Le Mans , 72037, France
Montpellier Cedex , 34295, France
SaintCloud , 92210, France
VandoeuvrelesNancy , 54511, France
Dublin , D8, Ireland
Milano , 20162, Italy
Novara , 28100, Italy
Reggio Emilia , 42123, Italy
Busan Busan Gwang'yeogsi, 47392, Korea, Republic of
Busan Busan Gwang'yeogsi, 49201, Korea, Republic of
Busan Busan Gwang'yeogsi, 49241, Korea, Republic of
Seongnamsi Gyeonggido, 13620, Korea, Republic of
Seoul Gyeonggido, 02841, Korea, Republic of
Daegu Gyeongsangbukdo, 41404, Korea, Republic of
Jinjusi Gyeongsangnamdo, 52727, Korea, Republic of
Hwasungun Jeonranamdo, 58128, Korea, Republic of
Seoul Seoul Teugbyeolsi, 03080, Korea, Republic of
Seoul Seoul Teugbyeolsi, 03722, Korea, Republic of
Seoul Seoul Teugbyeolsi, 04401, Korea, Republic of
Seoul Seoul Teugbyeolsi, 05505, Korea, Republic of
Seoul Seoul Teugbyeolsi, 06351, Korea, Republic of
Seoul Seoul Teugbyeolsi, 06591, Korea, Republic of
Rio Piedras , 00935, Puerto Rico
Burgos , 09006, Spain
Cadiz , 11009, Spain
Granada , 18014, Spain
Leon , 24071, Spain
Madrid , 28027, Spain
Madrid , 28031, Spain
Madrid , 28222, Spain
Murcia , 30120, Spain
Pamplona , 31008, Spain
Salamanca , 37007, Spain
Sevilla , 41013, Spain
Terassa , 8221, Spain
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