Non Hodgkin Lymphoma Clinical Trial

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

Summary

The purpose of the study is to compare the efficacy of zanubrutinib plus rituximab versus lenalidomide plus rituximab in participants with relapsed/refractory marginal zone lymphoma (R/R MZL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria.

View Eligibility Criteria

Eligibility Criteria

Key Inclusion Criteria:

Histologically confirmed grade 1-3a FL or MZL
Previously received ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
Need for systemic therapy for FL or MZL
Measurable disease by computed tomography or magnetic resonance imaging
Adequate bone marrow, liver and renal function

Key Exclusion Criteria:

Transformation to aggressive lymphoma
Requiring ongoing need for corticosteroid treatment
Clinically significant cardiovascular disease
Prior malignancy within the past 2 years
Active fungal, bacterial, and/or viral infection that requires systemic therapy

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 3

Estimated Enrollment:

750

Study ID:

NCT05100862

Recruitment Status:

Recruiting

Sponsor:

BeiGene

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There are 71 Locations for this study

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Kaiser Permanente Southern California
Irvine California, 92618, United States
Valkyrie Clinical Trials
Los Angeles California, 90067, United States
Baptist Md Anderson Cancer Center
Jacksonville Florida, 32207, United States
Northwest Georgia Oncology Centers Marietta
Marietta Georgia, 30060, United States
Fort Wayne Medical Oncology and Hematology
Fort Wayne Indiana, 46804, United States
Mission Cancer and Blood
Des Moines Iowa, 50309, United States
Cotton Oneil Cancer Center
Topeka Kansas, 66606, United States
Hattiesburg Hematology and Oncology Clinic
Hattiesburg Mississippi, 39401, United States
Oncology Hematology Associates
Springfield Missouri, 65807, United States
Summit Medical Group
Florham Park New Jersey, 07932, United States
Clinical Research Alliance, Inc
Westbury New York, 11590, United States
Cancer Care Associates of York
York Pennsylvania, 17403, United States
Md Anderson Cancer Center
Houston Texas, 77030, United States
Concord Repatriation General Hospital
Concord New South Wales, 2139, Australia
Gosford Hospital
Gosford New South Wales, 2250, Australia
St George Hospital
Kogarah New South Wales, 2217, Australia
Orange Health Hospital
Orange New South Wales, 2800, Australia
Port Macquarie Base Hospital
Port Macquarie New South Wales, 2444, Australia
Westmead Hospital
Westmead New South Wales, 2145, Australia
Sunshine Coast Hospital and Health Service
Birtinya Queensland, 4575, Australia
Townsville University Hospital
Douglas Queensland, 4814, Australia
Monash Health
Clayton Victoria, 3168, Australia
St Vincents Hospital Melbourne
Fitzroy Victoria, 3065, Australia
Austin Health
Heidelberg Victoria, 3084, Australia
Cabrini Hospital Malvern
Malvern Victoria, 3144, Australia
Epworth Freemasons
Melbourne Victoria, 3002, Australia
The Alfred Hospital
Melbourne Victoria, 3004, Australia
Perth Blood Institute
West Perth Western Australia, 6005, Australia
La Trobe Regional Hospital
Melbourne , 3844, Australia
Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen)
Florianopolis , 88020, Brazil
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
Porto Alegre , 90850, Brazil
Beijing Cancer Hospital
Beijing Beijing, 10014, China
Chongqing Cancer Hospital
Chongqing Chongqing, 40003, China
Wuxi Peoples Hospital
Wuxi Jiangsu, 21402, China
Fakultni Nemocnice Hradec Kralove
Hradec Kralove , 50005, Czechia
Hopital Prive Dantony, Departement Dhemathologie
Antony , 92160, France
Centre Hospitalier Le Mans
Le Mans , 72037, France
Chu Montpellier Hopital Saint Eloi
Montpellier Cedex , 34295, France
Institut Curie
SaintCloud , 92210, France
Centre Hospitalier Universitaire de Nancy Hopital de Brabois
VandoeuvrelesNancy , 54511, France
St Jamess Hospital
Dublin , D8, Ireland
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milano , 20162, Italy
Aou Maggiore Della Carita
Novara , 28100, Italy
Arcispedale S Maria Nuova Ausl Reggio Emilia Hematology Unit
Reggio Emilia , 42123, Italy
Inje University Busan Paik Hospital
Busan Busan Gwang'yeogsi, 47392, Korea, Republic of
Dong A University Hospital
Busan Busan Gwang'yeogsi, 49201, Korea, Republic of
Pusan National University Hospital
Busan Busan Gwang'yeogsi, 49241, Korea, Republic of
Seoul National University Bundang Hospital
Seongnamsi Gyeonggido, 13620, Korea, Republic of
Korea University Anam Hospital
Seoul Gyeonggido, 02841, Korea, Republic of
Kyungpook National University Chilgok Hospital
Daegu Gyeongsangbukdo, 41404, Korea, Republic of
Gyeongsang National University Hospital
Jinjusi Gyeongsangnamdo, 52727, Korea, Republic of
Chonnam National University Hwasun Hospital
Hwasungun Jeonranamdo, 58128, Korea, Republic of
Seoul National University Hospital
Seoul Seoul Teugbyeolsi, 03080, Korea, Republic of
Severance Hospital Yonsei University Health System
Seoul Seoul Teugbyeolsi, 03722, Korea, Republic of
Soon Chun Hyang University Hospital Seoul
Seoul Seoul Teugbyeolsi, 04401, Korea, Republic of
Asan Medical Center
Seoul Seoul Teugbyeolsi, 05505, Korea, Republic of
Samsung Medical Center
Seoul Seoul Teugbyeolsi, 06351, Korea, Republic of
The Catholic University of Korea, Seoul St Marys Hospital
Seoul Seoul Teugbyeolsi, 06591, Korea, Republic of
Pan American Oncology Trials, Llc
Rio Piedras , 00935, Puerto Rico
Hospital Universitario de Burgos
Burgos , 09006, Spain
Hospital Universitario Puerta Del Mar
Cadiz , 11009, Spain
Hospital Universitario Virgen de Las Nieves
Granada , 18014, Spain
Complejo Asistencial Universitario de Leon
Leon , 24071, Spain
Clinica Universidad de Navarra
Madrid , 28027, Spain
Hospital Universitario Infanta Leonor
Madrid , 28031, Spain
H Puerta de Hierro Majadahonda
Madrid , 28222, Spain
Hospital Clinico Universitario Virgen de La Arrixaca
Murcia , 30120, Spain
Clinica Universidad de Navarra Pamplona
Pamplona , 31008, Spain
Hospital Universitario de Salamanca
Salamanca , 37007, Spain
Hospital Universitario Virgen Del Rocio
Sevilla , 41013, Spain
Hospital Universitari Mutua Terrassa
Terassa , 8221, Spain

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 3

Estimated Enrollment:

750

Study ID:

NCT05100862

Recruitment Status:

Recruiting

Sponsor:


BeiGene

How clear is this clinincal trial information?

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