Non Hodgkin Lymphoma Clinical Trial
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Summary
The purpose of the study is to compare the efficacy of zanubrutinib plus rituximab versus lenalidomide plus rituximab in participants with relapsed/refractory marginal zone lymphoma (R/R MZL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria.
Eligibility Criteria
Key Inclusion Criteria:
Histologically confirmed grade 1-3a FL or MZL
Previously received ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
Need for systemic therapy for FL or MZL
Measurable disease by computed tomography or magnetic resonance imaging
Adequate bone marrow, liver and renal function
Key Exclusion Criteria:
Transformation to aggressive lymphoma
Requiring ongoing need for corticosteroid treatment
Clinically significant cardiovascular disease
Prior malignancy within the past 2 years
Active fungal, bacterial, and/or viral infection that requires systemic therapy
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
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There are 262 Locations for this study
Encinitas California, 92024, United States
Fresno California, 93730, United States
Irvine California, 92618, United States
Los Alamitos California, 90720, United States
Los Angeles California, 90067, United States
San Diego California, 92103, United States
Jacksonville Florida, 32207, United States
Tampa Florida, 33606, United States
Marietta Georgia, 30060, United States
Merriam Kansas, 66204, United States
Topeka Kansas, 66606, United States
Baltimore Maryland, 21201, United States
Detroit Michigan, 48202, United States
Hattiesburg Mississippi, 39401, United States
Springfield Missouri, 65807, United States
Grand Island Nebraska, 68803, United States
Florham Park New Jersey, 07932, United States
Westbury New York, 11590, United States
Cleveland Ohio, 44106, United States
Wynnewood Pennsylvania, 19096, United States
York Pennsylvania, 17403, United States
Nashville Tennessee, 37232, United States
Houston Texas, 77030, United States
Richmond Virginia, 23298, United States
Caba , 1181, Argentina
Caba , 1425, Argentina
Caba , 1425, Argentina
Caba , C1426, Argentina
Caba , C1431, Argentina
Caba , CP111, Argentina
Cordoba , 5000, Argentina
La Plata , 1900, Argentina
Pilar , 1629, Argentina
Concord New South Wales, 2139, Australia
Gosford New South Wales, 2250, Australia
Kogarah New South Wales, 2217, Australia
Port Macquarie New South Wales, 2444, Australia
Westmead New South Wales, 2145, Australia
Birtinya Queensland, 4575, Australia
Douglas Queensland, 4814, Australia
Box Hill Victoria, 3128, Australia
Clayton Victoria, 3168, Australia
Fitzroy Victoria, 3065, Australia
Heidelberg Victoria, 3084, Australia
Malvern Victoria, 3144, Australia
Melbourne Victoria, 3002, Australia
Melbourne Victoria, 3004, Australia
West Perth Western Australia, 6005, Australia
Melbourne , 3844, Australia
St Poelten , 3100, Austria
Vienna , 1140, Austria
Vienna , 1160, Austria
Wien , 1090, Austria
Anderlecht , 1070, Belgium
Brugge , 8000, Belgium
Gent , 9000, Belgium
Leuven , 3000, Belgium
Barretos , 14784, Brazil
Blumenau , 89010, Brazil
Botucatu , 18618, Brazil
Brasilia , 70390, Brazil
Campinas , 13083, Brazil
Caxias do Sul , 95070, Brazil
Curitiba , 80810, Brazil
Florianopolis , 88020, Brazil
Jardim Das Americas , 81520, Brazil
Porto Alegre , 90110, Brazil
Porto Alegre , 90160, Brazil
Recife , 50070, Brazil
Recife , 50070, Brazil
Ribeirao Preto , 14051, Brazil
Rio de Janeiro , 22061, Brazil
Rio de Janeiro , 22250, Brazil
Rio de Janeiro , 22775, Brazil
Rio de Janeiro , 24020, Brazil
Salvador , 41253, Brazil
Salvador , 41950, Brazil
Sao Paulo , 01323, Brazil
Sao Paulo , 01409, Brazil
Sao Paulo , 04501, Brazil
Sao Paulo , 05403, Brazil
Sao Paulo , 05652, Brazil
Sorocaba , 18618, Brazil
Vitoria , 29043, Brazil
Plovdiv , 4002, Bulgaria
Sofia , 1407, Bulgaria
Sofia , 1407, Bulgaria
Sofia , 1756, Bulgaria
Varna , 9010, Bulgaria
Greenfiled Park Quebec, J4V 2, Canada
Laval Quebec, H7M 3, Canada
Montreal Quebec, H1T 2, Canada
Montreal Quebec, H4J 1, Canada
Saskatoon Saskatchewan, S7N 4, Canada
Quebec , G1S 1, Canada
Wuhu Anhui, 24100, China
Beijing Beijing, 10005, China
Beijing Beijing, 10014, China
Chongqing Chongqing, 40003, China
Fuzhou Fujian, 35000, China
Xiamen Fujian, 36100, China
Lanzhou Gansu, 73000, China
Lanzhou Gansu, 73005, China
Foshan Guangdong, 52800, China
Guangzhou Guangdong, 51006, China
Huizhou Guangdong, 51600, China
Meizhou Guangdong, 51403, China
Zhanjiang Guangdong, 52400, China
Harbin Heilongjiang, 15000, China
Anyang Henan, 45500, China
Zhengzhou Henan, 45000, China
Wuhan Hubei, 43002, China
Wuhan Hubei, 43003, China
Changde Hunan, 41500, China
Nanjing Jiangsu, 21002, China
Nantong Jiangsu, 20120, China
Suzhou Jiangsu, 21500, China
Wuxi Jiangsu, 21402, China
Ganzhou Jiangxi, 34100, China
Nanchang Jiangxi, 33000, China
Nanchang Jiangxi, 33002, China
Changchun Jilin, 13002, China
Dalian Liaoning, 11600, China
Shenyang Liaoning, 11000, China
Rizhao Shandong, 27682, China
Taian Shandong, 27109, China
Weihai Shandong, 26420, China
Shanghai Shanghai, 20000, China
Taiyuan Shanxi, 03001, China
Chengdu Sichuan, 61004, China
Dongyang Zhejiang, 32210, China
Hangzhou Zhejiang, 31002, China
Jiaxing Zhejiang, 31400, China
Jinhua Zhejiang, 32100, China
Wenzhou Zhejiang, 32500, China
Hradec Kralove , 50005, Czechia
Olomouc , 77900, Czechia
Antony , 92160, France
Le Mans , 72037, France
Montpellier Cedex , 34295, France
Nice , 6200, France
Paris , 75015, France
SaintCloud , 92210, France
Strasbourg , 67033, France
VandoeuvrelesNancy , 54511, France
Batumi , 6000, Georgia
Kutaisi , 4600, Georgia
Tbilisi , 0112, Georgia
Tbilisi , 177, Georgia
Berlin , 10967, Germany
Berlin , 13353, Germany
Essen , 45147, Germany
Koln , 50937, Germany
Magdeburg , 39120, Germany
Ulm , 89081, Germany
Wurzburg , 97080, Germany
Alexandroupolis , 68100, Greece
Athens , 10676, Greece
Athens , 11528, Greece
Patras , 26504, Greece
Thessaloniki , 57010, Greece
Dublin , D8, Ireland
Galway , H91 Y, Ireland
Waterford , X91 E, Ireland
Afula , 18341, Israel
Ashdod , 77476, Israel
Jerusalem , 91031, Israel
Jerusalem , 91120, Israel
Petach Tikva , 49100, Israel
Ramat gan , 52656, Israel
Tel Aviv , 69714, Israel
Aviano , 33081, Italy
Bologna , 40138, Italy
Milano , 20141, Italy
Milano , 20162, Italy
Novara , 28100, Italy
Padova , 35128, Italy
Pavia , 27100, Italy
Ravenna , 48121, Italy
Reggio Emilia , 42123, Italy
Udine , 33100, Italy
Varese , 21100, Italy
Busan Busan Gwang'yeogsi, 49201, Korea, Republic of
Busan Busan Gwang'yeogsi, 49241, Korea, Republic of
Susan Busan Gwang'yeogsi, 614-7, Korea, Republic of
Seongnamsi Gyeonggido, 13620, Korea, Republic of
Seoul Gyeonggido, 02841, Korea, Republic of
Daegu Gyeongsangbukdo, 41404, Korea, Republic of
Jinjusi Gyeongsangnamdo, 52727, Korea, Republic of
Incheon Incheon Gwang'yeogsi, 21565, Korea, Republic of
Hwasungun Jeonranamdo, 58128, Korea, Republic of
Seoul Seoul Teugbyeolsi, 03722, Korea, Republic of
Seoul Seoul Teugbyeolsi, 04401, Korea, Republic of
Seoul Seoul Teugbyeolsi, 05505, Korea, Republic of
Seoul Seoul Teugbyeolsi, 06351, Korea, Republic of
Seoul Seoul Teugbyeolsi, 06591, Korea, Republic of
Seoul Seoul Teugbyeolsi, 3080, Korea, Republic of
Almere , 1315 , Netherlands
Doetinchem , 7009 , Netherlands
Ede , 6716R, Netherlands
Gorinchem , 4204 , Netherlands
Noord Brabant , 4708 , Netherlands
Rotterdam , 3083 , Netherlands
Zutphen , 7207 , Netherlands
Bydgoszcz , 85-16, Poland
Katowice , 40-05, Poland
Krakow , 30-72, Poland
Poznan , 60-56, Poland
Skorzewo Poznan , 60-18, Poland
Warsaw , 02-78, Poland
Warszawa , 02-09, Poland
Warszawa , 02-77, Poland
Almada , 4200-, Portugal
Braga , 4710-, Portugal
Porto , 4200-, Portugal
VILA NOVA DE GAIA Porto , 4434-, Portugal
Rio Piedras , 00935, Puerto Rico
Bucharest , 30171, Romania
Bucharest , O2012, Romania
ClujNapoca , 40001, Romania
Craiova , 20014, Romania
Iasi , 70085, Romania
Oradea , 41046, Romania
Cape Town , 7925, South Africa
Durban , 4001, South Africa
Kuils River , 7579, South Africa
Pretoria , O181, South Africa
Pretoria , OO84, South Africa
Pretoria , OO84, South Africa
Soweto , 2013, South Africa
Badalona , 08916, Spain
Burgos , 9006, Spain
Cadiz , 11009, Spain
Granada , 18014, Spain
Hospitalet de LLobregat , 8908, Spain
Leon , 24071, Spain
Madrid , 28006, Spain
Madrid , 28027, Spain
Madrid , 28031, Spain
Madrid , 28034, Spain
Madrid , 28222, Spain
Murcia , 30120, Spain
Pamplona , 31008, Spain
Pozuelo de Alarcon , 28223, Spain
Salamanca , 37007, Spain
Sevilla , 41013, Spain
Terassa , 8221, Spain
Fribourg , 1708, Switzerland
La ChauxdeFonds , 2300, Switzerland
Ankara Oncology Abdurrahman Yurtaslan Hospital , 06200, Turkey
Ankara , 06620, Turkey
Atakum Samsun , 55200, Turkey
Golba Ankara , 6830, Turkey
Istanbul , 34214, Turkey
Istanbul , 34365, Turkey
Istanbul , 34722, Turkey
Izmir , 35100, Turkey
Izmir , 35340, Turkey
Kocaeli , 41380, Turkey
Mersin , 33000, Turkey
Bournemouth , BH7 7, United Kingdom
Glasgow , G12 0, United Kingdom
Greater Manchester , M20 4, United Kingdom
Huddersfield , HD3 3, United Kingdom
Leeds , LS9 7, United Kingdom
London , NW1 2, United Kingdom
NewCastle Upon Tyne , NE7 7, United Kingdom
Plymouth , PL6 8, United Kingdom
Southampton , SO16 , United Kingdom
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