Non Hodgkin Lymphoma Clinical Trial
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Summary
The purpose of the study is to compare the efficacy of zanubrutinib plus rituximab versus lenalidomide plus rituximab in participants with relapsed/refractory marginal zone lymphoma (R/R MZL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria.
View Eligibility Criteria
Eligibility Criteria
Key Inclusion Criteria:
Histologically confirmed grade 1-3a FL or MZL
Previously treated with ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
Need for systemic therapy for FL or MZL
Measurable disease by computed tomography or magnetic resonance imaging
Adequate bone marrow, liver and renal function
Key Exclusion Criteria:
Transformation to aggressive lymphoma
Requiring ongoing need for corticosteroid treatment
Clinically significant cardiovascular disease
Prior malignancy within the past 2 years
Active fungal, bacterial, and/or viral infection that requires systemic therapy
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
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There are 170 Locations for this study
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Kaiser Permanente Southern California
Irvine California, 92618, United States
Irvine California, 92618, United States
Los Angeles Cancer Network
Los Angeles California, 90017, United States
Los Angeles California, 90017, United States
Valkyrie Clinical Trials
Los Angeles California, 90067, United States
Los Angeles California, 90067, United States
Scripps Health
San Diego California, 92103, United States
San Diego California, 92103, United States
Baptist Md Anderson Cancer Center
Jacksonville Florida, 32207, United States
Jacksonville Florida, 32207, United States
Ascension Sacred Heart
Pensacola Florida, 32504, United States
Pensacola Florida, 32504, United States
Northwest Georgia Oncology Centers Marietta
Marietta Georgia, 30060, United States
Marietta Georgia, 30060, United States
Fort Wayne Medical Oncology and Hematology
Fort Wayne Indiana, 46804, United States
Fort Wayne Indiana, 46804, United States
Mission Cancer and Blood
Des Moines Iowa, 50309, United States
Des Moines Iowa, 50309, United States
Cotton Oneil Cancer Center
Topeka Kansas, 66606, United States
Topeka Kansas, 66606, United States
University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore Maryland, 21201, United States
Baltimore Maryland, 21201, United States
American Oncology Partners of Maryland Pa
Bethesda Maryland, 20817, United States
Bethesda Maryland, 20817, United States
Henry Ford Hospital
Detroit Michigan, 48202, United States
Detroit Michigan, 48202, United States
Hattiesburg Hematology and Oncology Clinic
Hattiesburg Mississippi, 39401, United States
Hattiesburg Mississippi, 39401, United States
University of Missouri Hospital, Ellis Fischel Cancer Center
Columbia Missouri, 65212, United States
Columbia Missouri, 65212, United States
Oncology Hematology Associates
Springfield Missouri, 65807, United States
Springfield Missouri, 65807, United States
St Vincent Frontier Cancer Center
Billings Montana, 59102, United States
Billings Montana, 59102, United States
Nebraska Cancer Specialists (Satellite Site)
Grand Island Nebraska, 68803, United States
Grand Island Nebraska, 68803, United States
Nebraska Cancer Specialists
Grand Island Nebraska, 68803, United States
Grand Island Nebraska, 68803, United States
Summit Medical Group
Florham Park New Jersey, 07932, United States
Florham Park New Jersey, 07932, United States
Clinical Research Alliance, Inc
Westbury New York, 11590, United States
Westbury New York, 11590, United States
Va Northeast Ohio Healthcare System
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44106, United States
Toledo Clinic Cancer Center
Toledo Ohio, 43623, United States
Toledo Ohio, 43623, United States
Mainline Health Lankenau Institute For Medical Research
Wynnewood Pennsylvania, 19096, United States
Wynnewood Pennsylvania, 19096, United States
Cancer Care Associates of York
York Pennsylvania, 17403, United States
York Pennsylvania, 17403, United States
Prairie Lakes Healthcare System
Watertown South Dakota, 57201, United States
Watertown South Dakota, 57201, United States
Texas Oncology Baylorcharles A Sammons Cancer Center
Dallas Texas, 75246, United States
Dallas Texas, 75246, United States
Md Anderson Cancer Center
Houston Texas, 77030, United States
Houston Texas, 77030, United States
Medical Oncology Associates
Spokane Washington, 99208, United States
Spokane Washington, 99208, United States
Hospital Italiano de Buenos Aires
Buenos Aires , C1199, Argentina
Buenos Aires , C1199, Argentina
Concord Repatriation General Hospital
Concord New South Wales, 2139, Australia
Concord New South Wales, 2139, Australia
Gosford Hospital
Gosford New South Wales, 2250, Australia
Gosford New South Wales, 2250, Australia
St George Hospital
Kogarah New South Wales, 2217, Australia
Kogarah New South Wales, 2217, Australia
Orange Health Hospital
Orange New South Wales, 2800, Australia
Orange New South Wales, 2800, Australia
Port Macquarie Base Hospital
Port Macquarie New South Wales, 2444, Australia
Port Macquarie New South Wales, 2444, Australia
Westmead Hospital
Westmead New South Wales, 2145, Australia
Westmead New South Wales, 2145, Australia
Sunshine Coast Hospital and Health Service
Birtinya Queensland, 4575, Australia
Birtinya Queensland, 4575, Australia
Townsville University Hospital
Douglas Queensland, 4814, Australia
Douglas Queensland, 4814, Australia
Monash Health
Clayton Victoria, 3168, Australia
Clayton Victoria, 3168, Australia
St Vincents Hospital Melbourne
Fitzroy Victoria, 3065, Australia
Fitzroy Victoria, 3065, Australia
Austin Health
Heidelberg Victoria, 3084, Australia
Heidelberg Victoria, 3084, Australia
Cabrini Hospital Malvern
Malvern Victoria, 3144, Australia
Malvern Victoria, 3144, Australia
Epworth Freemasons
Melbourne Victoria, 3002, Australia
Melbourne Victoria, 3002, Australia
The Alfred Hospital
Melbourne Victoria, 3004, Australia
Melbourne Victoria, 3004, Australia
Perth Blood Institute
West Perth Western Australia, 6005, Australia
West Perth Western Australia, 6005, Australia
La Trobe Regional Hospital
Melbourne , 3844, Australia
Melbourne , 3844, Australia
Uk St Poelten
St Poelten , 3100, Austria
St Poelten , 3100, Austria
Medical Univeristy Vienna
Wien , 1090, Austria
Wien , 1090, Austria
Hospital de Amor Barretos
Barretos , 14784, Brazil
Barretos , 14784, Brazil
Clinica de Oncologia Reichow
Blumenau , 89010, Brazil
Blumenau , 89010, Brazil
Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu
Botucatu , 18618, Brazil
Botucatu , 18618, Brazil
Instituto Dor de Pesquisa E Ensino Distrito Federal
Brasilia , 70390, Brazil
Brasilia , 70390, Brazil
Universidade de Campinas Centro de Hematologia E Hemoterapia
Campinas , 13083, Brazil
Campinas , 13083, Brazil
Fundacao Universidade de Caxias Do Sul
Caxias do Sul , 95070, Brazil
Caxias do Sul , 95070, Brazil
Centro Integrado de Oncologia de Curitiba Ss Cionc
Curitiba , 80810, Brazil
Curitiba , 80810, Brazil
Hospital Erasto Gaertner
Curitiba , 81520, Brazil
Curitiba , 81520, Brazil
Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen)
Florianopolis , 88020, Brazil
Florianopolis , 88020, Brazil
Hospital Ernesto Dornelles
Porto Alegre , 90160, Brazil
Porto Alegre , 90160, Brazil
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
Porto Alegre , 90850, Brazil
Porto Alegre , 90850, Brazil
Instituto Dor de Pesquisa E Ensino
Recife , 50070, Brazil
Recife , 50070, Brazil
Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp
Ribeirao Preto , 14051, Brazil
Ribeirao Preto , 14051, Brazil
Oncoclinicas Rio de Janeiro Sa
Rio de Janeiro , 22250, Brazil
Rio de Janeiro , 22250, Brazil
Instituto Americas Ensino, Pesquisa E Inovacao
Rio de Janeiro , 22775, Brazil
Rio de Janeiro , 22775, Brazil
Complexo Hospitalar de Niteroi
Rio de Janeiro , 24020, Brazil
Rio de Janeiro , 24020, Brazil
Ensino E Terapia de Inovacao Clinica Amo Etica
Salvador , 41950, Brazil
Salvador , 41950, Brazil
Instituto Dor de Pesquisa E Ensino Sao Paulo
Sao Paulo , 01401, Brazil
Sao Paulo , 01401, Brazil
Hospital Nove de Julho Dasa
Sao Paulo , 01409, Brazil
Sao Paulo , 01409, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
Sao Paulo , 05653, Brazil
Sao Paulo , 05653, Brazil
Hospital Santa Rita de Cassia Afecc
Vitoria , 29043, Brazil
Vitoria , 29043, Brazil
The First Affiliated Hospital of Wannan Medical College
Wuhu Anhui, 24100, China
Wuhu Anhui, 24100, China
Beijing Friendship Hospital, Capital Medical University
Beijing Beijing, 10005, China
Beijing Beijing, 10005, China
Beijing Cancer Hospital
Beijing Beijing, 10014, China
Beijing Beijing, 10014, China
Chongqing Cancer Hospital
Chongqing Chongqing, 40003, China
Chongqing Chongqing, 40003, China
Foshan First Peoples Hospital
Foshan Guangdong, 52800, China
Foshan Guangdong, 52800, China
Sun Yat Sen University Cancer Center
Guangzhou Guangdong, 51006, China
Guangzhou Guangdong, 51006, China
Huizhou Central Peoples Hospital
Huizhou Guangdong, 51600, China
Huizhou Guangdong, 51600, China
Meizhou People Hospital
Meizhou Guangdong, 51403, China
Meizhou Guangdong, 51403, China
Affiliated Hospital of Guangdong Medical University
Zhanjiang Guangdong, 52400, China
Zhanjiang Guangdong, 52400, China
Harbin Medical University Cancer Hospital
Harbin Heilongjiang, 15000, China
Harbin Heilongjiang, 15000, China
Anyang Cancer Hospital
Anyang Henan, 45500, China
Anyang Henan, 45500, China
Henan Cancer Hospital
Zhengzhou Henan, 45000, China
Zhengzhou Henan, 45000, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan Hubei, 43002, China
Wuhan Hubei, 43002, China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan Hubei, 43003, China
Wuhan Hubei, 43003, China
The First Peoples Hospital of Changde City
Changde Hunan, 41500, China
Changde Hunan, 41500, China
Affiliated Hospital of Nantong University
Nantong Jiangsu, 20120, China
Nantong Jiangsu, 20120, China
The First Affiliated Hospital of Soochow University
Suzhou Jiangsu, 21500, China
Suzhou Jiangsu, 21500, China
Wuxi Peoples Hospital
Wuxi Jiangsu, 21402, China
Wuxi Jiangsu, 21402, China
Jiangxi Province Cancer Hospital
Nanchang Jiangxi, 33002, China
Nanchang Jiangxi, 33002, China
The First Affiliated Hospital of Nanchang University Branch Xianghu
Nanchang Jiangxi, 33200, China
Nanchang Jiangxi, 33200, China
The First Hospital of Jilin University
Changchun Jilin, 13002, China
Changchun Jilin, 13002, China
Shengjing Hospital of China Medical University
Shenyang Liaoning, 11000, China
Shenyang Liaoning, 11000, China
Peoples Hospital of Rizhao
Rizhao Shandong, 27682, China
Rizhao Shandong, 27682, China
The Second Affiliated Hospital of Shandong First Medical University
Taian Shandong, 27109, China
Taian Shandong, 27109, China
Shanxi Provincial Cancer Hospital
Taiyuan Shanxi, 03001, China
Taiyuan Shanxi, 03001, China
West China Hospital, Sichuan University
Chengdu Sichuan, 61004, China
Chengdu Sichuan, 61004, China
Dongyang Peoples Hospital
Dongyang Zhejiang, 32210, China
Dongyang Zhejiang, 32210, China
Zhejiang Cancer Hospital
Hangzhou Zhejiang, 31002, China
Hangzhou Zhejiang, 31002, China
The First Hospital of Jiaxing
Jiaxing Zhejiang, 31400, China
Jiaxing Zhejiang, 31400, China
Jinhua Municipal Central Hospital
Jinhua Zhejiang, 32100, China
Jinhua Zhejiang, 32100, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou Zhejiang, 32500, China
Wenzhou Zhejiang, 32500, China
Fakultni Nemocnice Hradec Kralove
Hradec Kralove , 50005, Czechia
Hradec Kralove , 50005, Czechia
Fakultni Nemocnice Olomouc
Olomouc , 77900, Czechia
Olomouc , 77900, Czechia
Hopital Prive Dantony, Departement Dhemathologie
Antony , 92160, France
Antony , 92160, France
Centre Hospitalier Le Mans
Le Mans , 72037, France
Le Mans , 72037, France
Chu Montpellier Hopital Saint Eloi
Montpellier Cedex , 34295, France
Montpellier Cedex , 34295, France
Hopital Larchet Chu Nice
Nice , 6200, France
Nice , 6200, France
Institut Curie
Paris , 75005, France
Paris , 75005, France
Necker University Hospital
Paris , 75015, France
Paris , 75015, France
Icans Institut de Cancerologie Strasbourg Europe
Strasbourg , 67033, France
Strasbourg , 67033, France
Centre Hospitalier Universitaire de Nancy Hopital de Brabois
VandoeuvrelesNancy , 54511, France
VandoeuvrelesNancy , 54511, France
St Jamess Hospital
Dublin , D8, Ireland
Dublin , D8, Ireland
University Hospital Waterford
Waterford , X91 E, Ireland
Waterford , X91 E, Ireland
Assuta Ashdod Medical Center
Ashdod , 77476, Israel
Ashdod , 77476, Israel
Shaare Zedek Medical Center
Jerusalem , 91031, Israel
Jerusalem , 91031, Israel
Hadassah En Karem Medical Center
Jerusalem , 91120, Israel
Jerusalem , 91120, Israel
Rabin Medical Center
Petach Tikva , 49100, Israel
Petach Tikva , 49100, Israel
Chaim Sheba Medical Center
Ramat gan , 52656, Israel
Ramat gan , 52656, Israel
Assuta Medical Center
Tel Aviv , 69714, Israel
Tel Aviv , 69714, Israel
Cro Irccs Aviano
Aviano , 33081, Italy
Aviano , 33081, Italy
Irccs Azienda Ospedaliero Universitaria Bologna
Bologna , 40138, Italy
Bologna , 40138, Italy
Istituto Europeo Di Oncologia
Milano , 20141, Italy
Milano , 20141, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milano , 20162, Italy
Milano , 20162, Italy
Aou Maggiore Della Carita
Novara , 28100, Italy
Novara , 28100, Italy
Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi
Pavia , 27100, Italy
Pavia , 27100, Italy
Arcispedale S Maria Nuova Ausl Reggio Emilia Hematology Unit
Reggio Emilia , 42123, Italy
Reggio Emilia , 42123, Italy
Aou Santa Maria Della Misericordia Di Udine
Udine , 33100, Italy
Udine , 33100, Italy
Ospedale Di Circolo E Fondazione Macchi
Varese , 21100, Italy
Varese , 21100, Italy
Inje University Busan Paik Hospital
Busan Busan Gwang'yeogsi, 47392, Korea, Republic of
Busan Busan Gwang'yeogsi, 47392, Korea, Republic of
Dong A University Hospital
Busan Busan Gwang'yeogsi, 49201, Korea, Republic of
Busan Busan Gwang'yeogsi, 49201, Korea, Republic of
Pusan National University Hospital
Busan Busan Gwang'yeogsi, 49241, Korea, Republic of
Busan Busan Gwang'yeogsi, 49241, Korea, Republic of
Seoul National University Bundang Hospital
Seongnamsi Gyeonggido, 13620, Korea, Republic of
Seongnamsi Gyeonggido, 13620, Korea, Republic of
Korea University Anam Hospital
Seoul Gyeonggido, 02841, Korea, Republic of
Seoul Gyeonggido, 02841, Korea, Republic of
Kyungpook National University Chilgok Hospital
Daegu Gyeongsangbukdo, 41404, Korea, Republic of
Daegu Gyeongsangbukdo, 41404, Korea, Republic of
Gyeongsang National University Hospital
Jinjusi Gyeongsangnamdo, 52727, Korea, Republic of
Jinjusi Gyeongsangnamdo, 52727, Korea, Republic of
Chonnam National University Hwasun Hospital
Hwasungun Jeonranamdo, 58128, Korea, Republic of
Hwasungun Jeonranamdo, 58128, Korea, Republic of
Seoul National University Hospital
Seoul Seoul Teugbyeolsi, 03080, Korea, Republic of
Seoul Seoul Teugbyeolsi, 03080, Korea, Republic of
Severance Hospital Yonsei University Health System
Seoul Seoul Teugbyeolsi, 03722, Korea, Republic of
Seoul Seoul Teugbyeolsi, 03722, Korea, Republic of
Soon Chun Hyang University Hospital Seoul
Seoul Seoul Teugbyeolsi, 04401, Korea, Republic of
Seoul Seoul Teugbyeolsi, 04401, Korea, Republic of
Asan Medical Center
Seoul Seoul Teugbyeolsi, 05505, Korea, Republic of
Seoul Seoul Teugbyeolsi, 05505, Korea, Republic of
Samsung Medical Center
Seoul Seoul Teugbyeolsi, 06351, Korea, Republic of
Seoul Seoul Teugbyeolsi, 06351, Korea, Republic of
The Catholic University of Korea, Seoul St Marys Hospital
Seoul Seoul Teugbyeolsi, 06591, Korea, Republic of
Seoul Seoul Teugbyeolsi, 06591, Korea, Republic of
Pan American Oncology Trials, Llc
Rio Piedras , 00935, Puerto Rico
Rio Piedras , 00935, Puerto Rico
Auxilio Mutuo Cancer Center
San Juan , 00917, Puerto Rico
San Juan , 00917, Puerto Rico
Coltea Clinical Hospital
Bucharest , 30171, Romania
Bucharest , 30171, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
ClujNapoca , 40001, Romania
ClujNapoca , 40001, Romania
Institutul Regional de Oncologie Iasi
Iasi , 70048, Romania
Iasi , 70048, Romania
Spitalul Clinic Judetean de Urgenta Bihor
Oradea , 41046, Romania
Oradea , 41046, Romania
Ico Badalona
Badalona , 08916, Spain
Badalona , 08916, Spain
Hospital Universitario de Burgos
Burgos , 09006, Spain
Burgos , 09006, Spain
Hospital Universitario Puerta Del Mar
Cadiz , 11009, Spain
Cadiz , 11009, Spain
Hospital Universitario Virgen de Las Nieves
Granada , 18014, Spain
Granada , 18014, Spain
Institut Catala Doncologia Hospital Duran I Reynals
Hospitalet de LLobregat , 8908, Spain
Hospitalet de LLobregat , 8908, Spain
Complejo Asistencial Universitario de Leon
Leon , 24071, Spain
Leon , 24071, Spain
Hospital de La Princesa
Madrid , 28006, Spain
Madrid , 28006, Spain
Clinica Universidad de Navarra
Madrid , 28027, Spain
Madrid , 28027, Spain
Hospital Universitario Infanta Leonor
Madrid , 28031, Spain
Madrid , 28031, Spain
Hospital Universitario Ramon Y Cajal
Madrid , 28034, Spain
Madrid , 28034, Spain
H Puerta de Hierro Majadahonda
Madrid , 28222, Spain
Madrid , 28222, Spain
Hospital Clinico Universitario Virgen de La Arrixaca
Murcia , 30120, Spain
Murcia , 30120, Spain
Clinica Universidad de Navarra Pamplona
Pamplona , 31008, Spain
Pamplona , 31008, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcon , 28223, Spain
Pozuelo de Alarcon , 28223, Spain
Hospital Universitario de Salamanca
Salamanca , 37007, Spain
Salamanca , 37007, Spain
Hospital Universitario Virgen Del Rocio
Sevilla , 41013, Spain
Sevilla , 41013, Spain
Hospital Universitari Mutua Terrassa
Terassa , 8221, Spain
Terassa , 8221, Spain
Beatson West of Scotland Cancer Centre
Glasgow , G12 0, United Kingdom
Glasgow , G12 0, United Kingdom
The Christie Hospital
Greater Manchester , M20 4, United Kingdom
Greater Manchester , M20 4, United Kingdom
Huddersfield Royal Infirmary
Huddersfield , HD3 3, United Kingdom
Huddersfield , HD3 3, United Kingdom
The Leeds Teaching Hospitals Nhs Trust
Leeds , LS9 7, United Kingdom
Leeds , LS9 7, United Kingdom
University College Hospital
London , NW1 2, United Kingdom
London , NW1 2, United Kingdom
Derriford Hospital
Plymouth , PL6 8, United Kingdom
Plymouth , PL6 8, United Kingdom
Southampton General Hospital
Southampton , SO16 , United Kingdom
Southampton , SO16 , United Kingdom
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