Non Hodgkin Lymphoma Clinical Trial

Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors

Summary

SURVIVORS

Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors.

Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. .

Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity.

CONTROLS

Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.

View Full Description

Full Description

NIRS is a portable, non-invasive, brain imaging device that uses low levels of non-ionizing light to record variations in blood flow in the brain. The NIRS is wearable and can read blood flow to the brain during physical activity.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

HL Survivors

Completed bleomycin and/or thoracic radiation therapy for HL at SJCRH.
<21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy.
SJLIFE or ACT/SJLIFE participants
English language proficiency.

Community Controls

SJLIFE control.
≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors.

Exclusion Criteria:

HL Survivors

History of cranial or total-body irradiation therapy.
History of intrathecal or high dose intravenous antimetabolite therapy.
History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.

Study is for people with:

Non Hodgkin Lymphoma

Estimated Enrollment:

100

Study ID:

NCT06421987

Recruitment Status:

Not yet recruiting

Sponsor:

St. Jude Children's Research Hospital

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There is 1 Location for this study

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St. Jude Children's Research Hospital
Memphis Tennessee, 38105, United States More Info
Nicholas Phillips, PhD
Contact
866-278-5833
[email protected]
Nicholas Phillips, PhD
Principal Investigator

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Study is for people with:

Non Hodgkin Lymphoma

Estimated Enrollment:

100

Study ID:

NCT06421987

Recruitment Status:

Not yet recruiting

Sponsor:


St. Jude Children's Research Hospital

How clear is this clinincal trial information?

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