CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Inclusion Criteria:

Must have a human leukocyte antigen (HLA)-matched or single allele-mismatched adult sibling serving as donor
Must have a myeloid or lymphoid malignant disease that is treated with TLI and ATG reduced intensity conditioning for allogeneic transplant (any of the following AML, myelodysplastic syndrome [MDS], myeloproliferative disease [MPD], CLL, B or T-cell NHL, HL)
Patients who due to age, pre-existing medical conditions, or, prior therapy are considered to be at high risk for regimen related toxicity associated with fully ablative transplant conditioning, and therefore reduced intensity conditioning is recommended
Ability to understand and the willingness to sign a written informed consent document; patients must have signed informed consent to participate in the trial
DONOR: Must be an HLA-matched or single allele mismatched sibling of enrolled transplant patient
DONOR: Must be 18-75 years of age, inclusive
DONOR: Must be in a state of general good health and have completed a donor evaluation with history, medical examination and standard blood tests within 35 days of starting the hematopoietic cell collection procedure; in order to fairly represent the interests of the donor, the donor evaluation and consent will be performed by a study team member other than the recipient's attending physician
DONOR: Must have a white blood cell count > 3.5 x 10^9/liter, platelets > 150 x 10^9/liter and hematocrit > 35%
DONOR: Must be capable of undergoing leukapheresis
DONOR: Must be able to understand and sign informed consent
DONOR: Must not be seropositive for HIV 1 and 2, hepatitis B surface antigen, hepatitis C antibody, human T-lymphotropic virus (HTLV) antibody, cytomegalovirus (CMV) immunoglobulin M (IgM), or rapid plasma reagin (RPR) (Treponema); donors with prior evidence of hepatitis B core antibody positivity will have a polymerase chain reaction (PCR) test done to evaluate for hepatitis B infection; donors with a positive hepatitis B PCR test are excluded
DONOR: Females must not be pregnant or lactating
DONOR: Must not have psychological traits or psychological or medical conditions which make them unlikely to tolerate the procedure
DONOR: Must not have developed a new malignancy requiring chemotherapy or radiation in the interval since apheresis for initial hematocrit (HCT)
PATIENT CRITERIA FOR PROCEEDING WITH CD8+ MEMORY T-CELL INFUSION:
Patients must be beyond day 30 and before day 60 after transplant
Patients must have evidence of mixed CD3 T-cell chimerism based on the day +28 (+/- 7 days) blood sample showing >= 5% and =< 95% donor type cells
Patients must have no evidence of active graft-versus-host disease at the time of the CD8+ memory T-cell infusion; patients with a history of acute GVHD overall grade II based on skin only involvement or upper gastrointestinal (GI) tract involvement only will be eligible; patients with a history of liver or lower GI tract GVHD will not be eligible
Patients must be on single immune suppression therapy with either tacrolimus or cyclosporine at the time of CD8+ memory T-cell infusion; prednisone at a physiologic dose of 5 mg per day or less is allowed
Patients must have a Karnofsky performance status of >= 60% at the time of the CD8+ memory T-cell infusion
Patients must not have an uncontrolled bacterial, fungal or viral infection, defined as progressive symptoms despite therapy, at the time of the CD8+ memory T-cell infusion; asymptomatic viremia is allowed

Patients must have adequate organ function and performance status at the time of the CD8+ memory T-cell infusion, defined by the following:

Total bilirubin =< 4 mg/dL
SGOT or SGPT =< 4 x ULN
Creatinine =< 3 mg/dL or estimated creatinine clearance >= 40ml/min

Exclusion Criteria:

Uncontrolled bacterial, viral or fungal infection defined as currently taking medication and progression of clinical symptoms
Progressive hemato-lymphoid malignancy despite conventional therapy
Acute leukemia not in remission
Chronic myelogenous leukemia (CML)
Active central nervous system (CNS) involvement of the underlying malignancy
Human immunodeficiency virus (HIV) positive
Pregnant or lactating
Prior malignancy (EXCEPTION: diagnosed > 5 years ago without evidence of disease, OR treated =< 5 years ago but have a greater than 50% chance of life expectancy of >= 5 years for that malignancy)
Have a psychiatric disorder(s) or psychosocial circumstance(s) which in the opinion of the primary physician would place the patient at an unacceptable risk from transplant
Ejection fraction < 30%, or uncontrolled cardiac failure
Diffusing capacity of the lung for carbon monoxide (DLCO) < 40% predicted
Total bilirubin > 3 mg/dL
Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) > 4 x upper limit of normal (ULN)
Creatinine > 2 mg/dL and an estimated creatinine clearance =< 40 mL/min
Poorly controlled hypertension despite multiple antihypertensive medication OR
Karnofsky performance status (KPS) < 60%
Note: Patients positive for hepatitis B and C will be evaluated on a case by case basis