Non Hodgkin Lymphoma Clinical Trial
Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma
Summary
This research study is collecting and storing tissue samples from patients with rare or cutaneous non-Hodgkin lymphoma. Collecting and storing samples of tissue from patients with cancer to test in the laboratory may help the study of cancer in the future.
Full Description
OBJECTIVES:
I. To determine the clinical features, treatment, and outcome of patients with rare or cutaneous pediatric non-Hodgkin lymphoma (NHL).
II. To determine the pathologic and biologic features of these diseases, including molecular diagnostics and flow cytometry.
III. To establish a bank of these pathologically reviewed diseases and make specimens of blood and tissue available to qualified researchers.
IV. To determine sub-groups of these diseases that could be targeted for future biologic, pathologic, or therapeutic studies.
OUTLINE:
On study data will include presenting symptoms and signs, physical description of the tumor if it is on the skin, results of metastatic evaluation, stage (if available), blood count, markers, and the results of viral serologies. Any existing underlying conditions that could predispose to lymphoma will also be noted. Demographic and outcomes data will be stored and maintained by the COG Research Data Center. Demographic data will be linked to the specimen data in the BPC database.
The approach of this study is prospective data collection, including central pathologic review, relevant biologic studies, submission of material to the Biopathology Center (BPC) and collection of diagnostic and outcome data. Participants will be registered with a standard COG registration form for documentation of age, gender, race, date of diagnosis, initial presentation, initial work-up, and stage according to the standard staging for the specific disease, initial diagnostic procedure, and institutional diagnosis. Tissue will be sent according to guidelines in Section 4.0. Follow-up data, including relapse or progression and vital status will be reported annually for 5 years.
Patients will be followed annually for 5 years and data will be collected including vital status, evidence/absence of disease, type of treatment received, progression/relapse and whether the patient continues on study.
Eligibility Criteria
Inclusion Criteria:
Diagnosis of NHL
Any histology, except for Burkitt or Burkitt-like, diffuse large B-cell, anaplastic large cell, or lymphoblastic lymphoma
Primary CNS, primary cutaneous NHL, or lymphoproliferative diseases of any histology allowed
Pathological specimen from site not treated within the past 6 months
Must have specimens available
At least 6 months since prior chemotherapy irradiation to study lesion
At least 2 weeks since prior steroids
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There are 125 Locations for this study
Birmingham Alabama, 35233, United States
Birmingham Alabama, 35233, United States
Phoenix Arizona, 85016, United States
Little Rock Arkansas, 72202, United States
Little Rock Arkansas, 72205, United States
Downey California, 90242, United States
Long Beach California, 90806, United States
Los Angeles California, 90027, United States
Oakland California, 94609, United States
Oakland California, 94611, United States
Palo Alto California, 94304, United States
San Francisco California, 94143, United States
San Francisco California, 94158, United States
Santa Barbara California, 93102, United States
Aurora Colorado, 80045, United States
Denver Colorado, 80218, United States
Hartford Connecticut, 06106, United States
Wilmington Delaware, 19803, United States
Washington District of Columbia, 20007, United States
Washington District of Columbia, 20010, United States
Fort Myers Florida, 33901, United States
Fort Myers Florida, 33908, United States
Hollywood Florida, 33021, United States
Jacksonville Florida, 32207, United States
Miami Florida, 33136, United States
Orlando Florida, 32806, United States
Orlando Florida, 32827, United States
Pensacola Florida, 32504, United States
Saint Petersburg Florida, 33701, United States
Tampa Florida, 33606, United States
Tampa Florida, 33607, United States
West Palm Beach Florida, 33407, United States
Atlanta Georgia, 30322, United States
Savannah Georgia, 31404, United States
Chicago Illinois, 60612, United States
Oak Lawn Illinois, 60453, United States
Park Ridge Illinois, 60068, United States
Park Ridge Illinois, 60068, United States
Peoria Illinois, 61637, United States
Indianapolis Indiana, 46202, United States
Indianapolis Indiana, 46260, United States
Des Moines Iowa, 50309, United States
Iowa City Iowa, 52242, United States
Kansas City Kansas, 66160, United States
Lexington Kentucky, 40536, United States
New Orleans Louisiana, 70121, United States
Bangor Maine, 04401, United States
Baltimore Maryland, 21215, United States
Baltimore Maryland, 21287, United States
Bethesda Maryland, 20889, United States
Boston Massachusetts, 02114, United States
Boston Massachusetts, 02215, United States
Detroit Michigan, 48201, United States
Detroit Michigan, 48236, United States
East Lansing Michigan, 48824, United States
Flint Michigan, 48503, United States
Grand Rapids Michigan, 49503, United States
Rochester Minnesota, 55905, United States
Jackson Mississippi, 39216, United States
Columbia Missouri, 65201, United States
Kansas City Missouri, 64108, United States
Saint Louis Missouri, 63110, United States
Omaha Nebraska, 68114, United States
Omaha Nebraska, 68198, United States
Las Vegas Nevada, 89102, United States
Las Vegas Nevada, 89106, United States
Las Vegas Nevada, 89109, United States
Las Vegas Nevada, 89135, United States
Las Vegas Nevada, 89144, United States
Lebanon New Hampshire, 03756, United States
Hackensack New Jersey, 07601, United States
Livingston New Jersey, 07039, United States
Morristown New Jersey, 07960, United States
New Brunswick New Jersey, 08901, United States
Newark New Jersey, 07112, United States
Paterson New Jersey, 07503, United States
Summit New Jersey, 07902, United States
Bronx New York, 10467, United States
Brooklyn New York, 11201, United States
Buffalo New York, 14263, United States
New York New York, 10016, United States
New York New York, 10032, United States
Syracuse New York, 13210, United States
Valhalla New York, 10595, United States
Asheville North Carolina, 28801, United States
Charlotte North Carolina, 28204, United States
Durham North Carolina, 27710, United States
Akron Ohio, 44308, United States
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44195, United States
Columbus Ohio, 43205, United States
Dayton Ohio, 45404, United States
Oklahoma City Oklahoma, 73104, United States
Portland Oregon, 97227, United States
Portland Oregon, 97227, United States
Bethlehem Pennsylvania, 18017, United States
Danville Pennsylvania, 17822, United States
Hershey Pennsylvania, 17033, United States
Philadelphia Pennsylvania, 19104, United States
Philadelphia Pennsylvania, 19104, United States
Pittsburgh Pennsylvania, 15224, United States
Columbia South Carolina, 29203, United States
Knoxville Tennessee, 37916, United States
Nashville Tennessee, 37232, United States
Austin Texas, 78723, United States
Corpus Christi Texas, 78411, United States
Dallas Texas, 75230, United States
Fort Sam Houston Texas, 78234, United States
Fort Worth Texas, 76104, United States
Houston Texas, 77030, United States
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
Salt Lake City Utah, 84113, United States
Norfolk Virginia, 23507, United States
Seattle Washington, 98105, United States
Spokane Washington, 99204, United States
Charleston West Virginia, 25304, United States
Marshfield Wisconsin, 54449, United States
Milwaukee Wisconsin, 53226, United States
Perth Western Australia, 6008, Australia
Edmonton Alberta, T6G 2, Canada
Vancouver British Columbia, V6H 3, Canada
Winnipeg Manitoba, R3E 0, Canada
Halifax Nova Scotia, B3K 6, Canada
Hamilton Ontario, L8N 3, Canada
Toronto Ontario, M5G 1, Canada
Montreal Quebec, H3T 1, Canada
Saskatoon Saskatchewan, S7N 4, Canada
Quebec , G1V 4, Canada
San Juan , 00912, Puerto Rico
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