Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin’s Lymphoma or Hodgkin’s Lymphoma

DISEASE CHARACTERISTICS:

Histologically confirmed non-Hodgkin's lymphoma

No lymphoblastic lymphoma

Under 55 years of age:

Intermediate and high grade or aggressive disease that has relapsed and/or failed at least 2 salvage chemotherapy regimens OR
Failed to achieve complete response after first line induction chemotherapy and failed at least 1 salvage chemotherapy regimen
Low grade or indolent disease that has relapsed or failed to achieve complete response after first line induction chemotherapy and failed more than 2 salvage chemotherapy regimens

55 years of age and over:

Intermediate and high grade or aggressive disease that has relapsed and/or failed to achieve complete response after first line induction chemotherapy
Low grade or indolent disease that has relapsed or failed to achieve complete response after first line induction chemotherapy OR

Histologically confirmed Hodgkin's lymphoma

Under 55 years of age:

Received at least 2 prior salvage chemotherapy regimens

55 years of age and over:

Stage III or IV disease that has relapsed or failed to achieve remission after combination induction chemotherapy
Prior primary radiotherapy allowed if relapse is high risk (e.g., recurrence in radiation field, B symptoms, or liver or bone marrow involvement)

No active leptomeningeal involvement or severe symptomatic CNS disease

Prior CSF tumor involvement allowed if asymptomatic and no evidence of disease on lumbar puncture or no tumor involvement on MRI of the brain

Solid tumors and brain metastases allowed

No evidence of disease by MRI and physical exam following optimal prior surgery and/or radiotherapy AND
At least 3 months since prior radiotherapy NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.

PATIENT CHARACTERISTICS:

Age:

18 to 64

Performance status:

ECOG 0-1

Life expectancy:

Not specified

Hematopoietic:

Not specified

Hepatic:

Bilirubin no greater than 2.0 mg/dL*
SGOT or SGPT no greater than 2.5 times normal*
No severe hepatic dysfunction NOTE: *Unless due to primary malignancy

Renal:

Creatinine no greater than 2.0 mg/dL OR
Creatinine clearance at least 60 mL/min

Cardiovascular:

No severe cardiac dysfunction
Ejection fraction at least 50% by MUGA scan
Essential hypertension controlled by medication allowed

Pulmonary:

DLCO at least 50% of normal OR
No symptomatic obstructive or restrictive disease

Other:

Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective barrier contraception
No active infection
HIV negative
No insulin dependent diabetes mellitus
No uncompensated major thyroid or adrenal dysfunction
No significant skin breakdown from tumor or other disease
No other prior malignancy within the past 5 years except nonmelanoma skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy:

Not specified

Chemotherapy:

See Disease Characteristics
Prior doxorubicin or daunorubicin allowed if total dose no greater than 450 mg/m2
No prior topotecan

Endocrine therapy:

Not specified

Radiotherapy:

See Disease Characteristics

Surgery:

See Disease Characteristics

Other:

No concurrent nitroglycerin preparations for angina pectoris
No concurrent antiarrhythmic drugs for major ventricular arrhythmias