Non Hodgkin Lymphoma Clinical Trial
Cyclophosphamide W/or W/Out Rituximab and Peripheral Stem Cell Transplantation in Patients With Recurrent Non-Hodgkin’s Lymphoma
RATIONALE: Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. It is not yet known if combining rituximab with cyclophosphamide is more effective than cyclophosphamide alone in stimulating peripheral stem cells for transplantation.
PURPOSE: This randomized phase II trial is studying how well giving cyclophosphamide with or without rituximab followed by chemotherapy and peripheral stem cell transplantation works in treating patients with recurrent non-Hodgkin's lymphoma.
Compare the effects of mobilization therapy with or without rituximab on hematopoietic stem cells, B and T lymphocytes, and natural killer cells in patients with advanced or recurrent B-cell non-Hodgkin's lymphoma.
Compare the effects of B-lymphocyte purging using concurrent rituximab and mobilization therapy vs a CD34+ cell enrichment device on hematopoietic stem cells, B and T lymphocytes, and natural killer cells in the peripheral blood stem cell (PBSC) infusates.
Compare the effect of these purging regimens on tumor cell content of PBSC infusates.
Compare the effects of these regimens on myeloid and lymphoid engraftment after high-dose chemotherapy and autologous PBSC infusion in these patients.
Compare post-transplantation infection complications in patients treated with these regimens.
Compare the response and relapse-free survival of patients treated with these regimens.
OUTLINE: This is a randomized study. Patients are randomized to 1 of 2 treatment arms.
Arm I: Patients receive mobilization therapy comprising rituximab IV over 2-5 hours on days 1, 8, and 15 and cyclophosphamide IV over 3-6 hours on day 16. Beginning 36-48 hours after the completion of cyclophosphamide, patients receive filgrastim (G-CSF) subcutaneously (SC) daily until blood counts recover. Patients then undergo peripheral blood stem cell (PBSC) collection.
After completion of PBSC collection, patients receive high-dose chemotherapy comprising carmustine IV on days -7 to -3 and etoposide IV and cisplatin IV for 3 days during days -7 to -3. Patients may undergo involved-field radiotherapy to active or previously bulky (more than 5 cm) tumors daily for 7-10 days.
Patients receive unmanipulated PBSCs on day 0. Patients receive G-CSF SC daily beginning 4 hours after completion of PBSC infusion and continuing until neutrophil engraftment.
Arm II: Patients receive mobilization therapy comprising cyclophosphamide and G-CSF and high-dose chemotherapy comprising carmustine, etoposide, and cisplatin as in arm I. Patients may also undergo involved-field radiotherapy as in arm I. Patients receive CD34 cell-enriched PBSC on day 0 followed by G-CSF as in arm I.
Patients are followed every 3 months.
PROJECTED ACCRUAL: A total of 71 patients will be accrued for this study within 2 years.
Histologically confirmed B-cell non-Hodgkin's lymphoma (NHL)
Indolent or aggressive histology
No small lymphocytic lymphoma, Burkitt's lymphoma, or small lymphocytic non-Burkitt's lymphoma
CD20-positive and/or CD19-positive by immunohistochemistry or flow cytometry
Second or greater remission allowed
Partial remission, relapse, or refractory disease must have measurable tumor
Eligible for high-dose therapy followed by autologous peripheral blood stem cell transplantation
No CNS involvement by lymphoma
12 to 65
Absolute neutrophil count greater than 1,200/mm^3
Platelet count greater than 100,000/mm^3
Bilirubin less than 2.0 mg/dL
Creatinine clearance at least 60 mL/min
No renal dysfunction
LVEF at least 40%
No cardiac dysfunction
No myocardial infarction within the past 3 months
FEV_1 greater than 60%
DLCO at least 60% of predicted
No pulmonary dysfunction
No significant organ dysfunction
No severe comorbid condition
No uncontrolled diabetes
No severe or active infection
Not pregnant or nursing
Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
No prior immunotherapy
No prior high-dose chemotherapy with or without peripheral blood stem cell transplantation
No more than 3 prior chemotherapy regimens for NHL
At least 4 weeks since prior chemotherapy and recovered
Prior radiotherapy allowed
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There is 1 Location for this study
Cleveland Ohio, 44106, United States
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