Non Hodgkin Lymphoma Clinical Trial
Impact of Respiratory Training in Lymphoma Survivors
Summary
High-resistance inspiratory muscle strength training (IMST) is a time-efficient (~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.
Full Description
Cancer survivorship has been steadily improving as a result of earlier detection and improved therapies. Behind cancer recurrence, the primary cause of morbidity and mortality among survivors stems from the onset of cardiovascular disease that arises in part due to cardiotoxic chemo and radiation therapies. The increased risk of cardiovascular disease is particularly high in specific survivor populations, such as lymphoma survivors. Although exercise has been demonstrated to improve both recovery after cancer therapy and quality of life, both physical and logistical hurdles may prohibit certain patients from accessing this intervention. High-resistance inspiratory muscle strength training (IMST) is a time-efficient (~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.
Eligibility Criteria
Inclusion Criteria:
Age 18 - 80
Primary cancer diagnosis of lymphoma
Able and willing to participate in a supervised exercise program at the Anschutz Health and Wellness Center
Provides a signed physician exercise clearance form
SBP > 120 mmHg
Completion of curative cancer treatment over 12 months prior (individuals on maintenance therapy will be included)
Possession of a smartphone compatible with the IMST training application (available on both Android and Apple).
Exclusion Criteria:
oSecond active cancer diagnosis
oPlanned active cancer treatment or change in current treatment in the next 6 months
Severe obesity (BMI > 40 kg/m2) or underweight (BMI < 18.5 kg/m2)
Unstable weight (> 3 kg change in body mass in last 3 months)
Significant metabolic disorder (e.g. diabetes type II)
Uncontrolled thyroid disease
Recent changes in hypertensive medication (within last 3 months)
Greater than 100 min of self-reported regular exercise per week
Any medical condition that would impact the safety of, or participation in, an exercise program, including:
Significant pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
Known cardiovascular disease, significant hypertension (> 180/120), or a recent cardiac event (within past 6 months)
Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
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