Ovarian Cancer Clinical Trial

A Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Patients With Advanced Platinum-sensitive Ovarian Cancer

Summary

The study will include a safety run-in phase (Stage 1) and a randomization phase (Stage 2).

The purpose of Stage 1 is to evaluate the safety of cobimetinib when administered in combination with niraparib (Cohort 1) and cobimetinib with niraparib plus atezolizumab (Cohort 2).

Stage 1 will enable patient enrollment in the randomized phase of the study (Stage 2) with both regimens at the recommended dose levels from Stage 1.

Stage 2 is a randomized, dose-expansion phase, evaluating clinical outcomes in patients with advanced platinum-sensitive ovarian cancer.

All patients will continue to receive study treatment until disease progression (according to "Response Evaluation Criteria in Solid Tumors" (RECIST), Version 1.1, unacceptable toxicity, death, or patient or investigator decision to withdraw, whichever occurs first.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria

Ability to comply with the study protocol, in the investigator's judgment
Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures, including the completion of patient-reported outcome questionnaires
Histological diagnosis of high-grade serous or Grade 2 or Grade 3 endometrioid epithelial ovarian, fallopian tube, or primary peritoneal cancer
Previous treatment with a minimum of one and a maximum of two prior platinum based treatment regimens
Platinum-sensitive disease
Availability of tumor biopsy tissue prior to first dose of study treatment with confirmation by the central laboratory that the sample is not only of adequate quality but also assignable to a molecularly defined subgroup based on breast cancer susceptibility gene (BRCA) and loss of heterozygosity (LOH) status
Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1)
Adequate hematologic and organ function
Eastern Cooperative Oncology Group Performance Status of 0 or 1
Life expectancy of at least 12 weeks
Resolved or stabilized toxicities resulting from previous therapy to Grade 1
Negative HIV test at screening
Negative hepatitis B surface antigen and total hepatitis B core antibody (HBcAb) test, or positive total HBcAb test followed by quantitative hepatitis B virus (HBV) DNA < 500 IU/mL test at screening
Negative hepatitis C virus (HCV) antibody test, or positive HCV antibody test followed by a negative HCV RNA test at screening
For women of childbearing potential: Women must remain abstinent or use two contraceptive methods with a failure rate of <1% per year during the treatment period and for at least 3 months after the last dose of cobimetinib, 6 months after the last dose of niraparib, and 5 months after the last dose of atezolizumab. Women must refrain from donating eggs during this same period

Exclusion Criteria

Prior treatment with mitogen-activated protein kinase inhibitor, polyadenosine diphosphate-ribose polymerase inhibitor, or immune checkpoint inhibitor therapies
Prior chemotherapy, hormonal therapy, radiotherapy, antibody therapy, or other immunotherapy, gene therapy, vaccine therapy, or treatment with experimental drugs within 14 days prior to first dose of study treatment
Treatment with systemic immunostimulatory agents within 28 days or 5 half-lives of the drug prior to initiation of study treatment
Treatment with systemic immunosuppressive medication 14 days prior to initiation of study treatment, or anticipation of need for systemic immunosuppressive medication during the study
History of other malignancy that could affect compliance with the protocol or interpretation of results, or known to have potentially fatal outcome
Symptomatic and/or untreated central nervous system metastases
Surgical procedure, significant traumatic injury within 14 days prior to enrollment, or anticipation of need for major surgical procedure during the study
Minor surgical procedure within 3 days
History or evidence of retinal pathology on ophthalmic examination
Left ventricular ejection fraction below institutional lower limit of normal
History of clinically significant cardiovascular dysfunction
History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on the screening chest computed tomography scan
History or evidence of inherited bleeding diathesis or significant coagulopathy at risk for bleeding
History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins, or to any component of the atezolizumab formulation
Known allergy or hypersensitivity to any component of the cobimetinib or niraparib formulation
Active or history of autoimmune disease or immune deficiency including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, anti-phospholipid antibody syndrome, Wegener granulomatosis, Sjögren syndrome, Guillain-Barre syndrome, or multiple sclerosis
Uncontrolled serious medical or psychiatric illness
History of malabsorption or other condition that would interfere with absorption of oral study drugs, including preexisting duodenal stent or ongoing intestinal obstruction
Active tuberculosis
Severe infection within 14 days prior to initiation of study treatment, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
Treatment with therapeutic oral or IV antibiotics within 7 days prior to initiation of study treatment
Treatment with a live, attenuated influenza vaccine within 28 days prior to study treatment initiation, at any time during the study, and for at least 5 months after the last dose of study drug
Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates the use of an investigational drug, may affect the interpretation of the results, or may render the patient at high risk from treatment complications
Previous treatment with strong CYP3A inhibitors (such as ketoconazole and clarithromycin), strong CYP3A inducers (such as carbamazepine and phenytoin), and moderate CYP3A inducers (such as efavirenz, modafinil) within 7 days prior to the initiation of study treatment or with ongoing requirements for these medications
Pregnancy or breastfeeding, or intention to become pregnant during the study

Study is for people with:

Ovarian Cancer

Phase:

Phase 1

Estimated Enrollment:

70

Study ID:

NCT03695380

Recruitment Status:

Recruiting

Sponsor:

Hoffmann-La Roche

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There are 29 Locations for this study

See Locations Near You

University of Arizona Cancer Center, North
Tucson Arizona, 85719, United States
Moores Cancer Center at UC San Diego Health
La Jolla California, 92093, United States
Sutter Health
San Francisco California, 94109, United States
Mayo Clinic-Jacksonville
Jacksonville Florida, 32224, United States
Florida Hospital Cancer Institute; Clinical Research Department
Orlando Florida, 32804, United States
Medical College of Georgia; Obstetrics & Gynecolog
Augusta Georgia, 30912, United States
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore Maryland, 21287, United States
Washington University School of Medicine; Dept of Medicine/Div of Medical Oncology
Saint Louis Missouri, 63108, United States
Columbia University Medical Center
New York New York, 10032, United States
Stephenson Cancer Center Investigational Pharmacy
Oklahoma City Oklahoma, 73104, United States
Jordan Center for Gynecologic Cancers
Philadelphia Pennsylvania, 19104, United States
Tennessee Oncology; Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States
VCU Massey Cancer Center, Dalton Oncology Clinic
Richmond Virginia, 23298, United States
Medical College of Wisconsin; Department of Obstetrics and Gynecology
Milwaukee Wisconsin, 53226, United States
Institut Bergonié Centre Régional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest
Bordeaux , 33076, France
Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale
Paris , 75908, France
Centre Hospitalier Lyon Sud
Pierre Benite , 69495, France
Istituto Nazionale Tumori Fondazione G. Pascale
Napoli Campania, 80131, Italy
Fondazione Policlinico Universitario "A. Gemelli"; Unità di Fase 1: Unità di Farmacologia Clinica
Rome Lazio, 00168, Italy
Istituto Nazionale dei Tumori; Divisione Oncologia Chirurgica e Ginecologica
Milano Lombardia, 20133, Italy
Istituto Europeo di Oncologia; Svil. Nuovi Farmaci per Terapie Innovative
Milano Lombardia, 20141, Italy
Centro Oncologico de Galicia COG; Medical Oncology
A Coruna LA Coruña, 15009, Spain
Hospital Universitari Vall dHebron; Oncology
Barcelona , 08035, Spain
ICO Girona
Girona , 17007, Spain
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaen , 23007, Spain
Clinica Universidad de Navarra Madrid; Servicio de Oncología
Madrid , 28027, Spain
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid , 28034, Spain
Hospital Clinico San Carlos; Servicio de Oncologia
Madrid , 28040, Spain
Hospital Clínico Universitario de Valencia; Servicio de Oncología
Valencia , 46010, Spain

How clear is this clinincal trial information?

Study is for people with:

Ovarian Cancer

Phase:

Phase 1

Estimated Enrollment:

70

Study ID:

NCT03695380

Recruitment Status:

Recruiting

Sponsor:


Hoffmann-La Roche

How clear is this clinincal trial information?

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