Ovarian Cancer Clinical Trial
A Trial of Intravenous Denileukin Diftitox in Stage III or IV Ovarian Cancer
Summary
This study tests whether denileukin diftitox will deplete regulatory T cells, boost tumor-specific immunity and treat epithelial ovarian cancer in patients who have failed, or who are ineligible for front line therapy.
Full Description
This is a non-randomized, single-arm, Phase II trial. Selected patients with advanced-stage epithelial ovarian cancers who have no reasonable chance of cure using standard regimens, or who will not receive such regimens (due to contraindication or intolerance) are eligible. Patients will be treated with Ontak at 12 µg/kg monthly as long as they meet response criteria.
Eligibility Criteria
Inclusion Criteria:
Able to provide informed consent
Not on Immune modulating drugs
Life expectancy less than 6 months
Exclusion Criteria:
Unable to tolerate phlebotomy
Germ cell or stromal cell cancers of the ovaries
Active autoimmune disease
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There is 1 Location for this study
San Antonio Texas, 78229, United States
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