Ovarian Cancer Clinical Trial
Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors
Summary
This study will determine the maximum-tolerated dose (MTD) for oral bosutinib when used in combination with pemetrexed. The MTD is the highest dose of bosutinib with pemetrexed that can be given without causing severe side effects. This study will also test the safety of this combination and see what effects (good or bad) it has on participants and their cancer.
Eligibility Criteria
Inclusion Criteria:
Pathologically or cytologically proven advanced, metastatic non-squamous non-small cell lung cancer, pleural malignant mesothelioma, bladder or urethral cancer, ovarian cancer, primary peritoneal cancer, thymoma and thymic cancer and uterine cervical cancer.
Measurable disease
Life expectancy of greater than 3 months.
Ability to take folic acid, vitamin B12, and dexamethasone according to protocol.
Exclusion Criteria:
- Untreated or symptomatic brain metastases.
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There is 1 Location for this study
Augusta Georgia, 30912, United States
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