Ovarian Cancer Clinical Trial
Collection of Malignant Ascites, Pleural Fluid, and Blood From People With Solid Tumors
Researchers want to study fluids and blood of people with cancer. The fluids are from the abdomen and around the lungs. Studying these might help researchers learn about the biology of cancer. This may lead to better ways to treat cancer.
To study the biology of cancer.
Adults 18 and older with malignant solid tumors.
Participants will be screened with medical history, blood tests, and confirmation of diagnosis.
Participants will have samples taken at regularly scheduled procedures. Fluids from the abdomen and/or lungs will be taken as part of the procedures. Blood will be taken separately.
Participants may be asked to give more samples at future procedures.
-Malignant ascites or pleural effusions are often seen in patients with solid tumor
-Malignant ascites is proinflammatory with many cytokines present and acts to promote
tumor cell growth.
-The cellular composition of malignant ascites consists of lymphocytes, macrophages and
-Serum monocytes and lymphocytes play a role in the native host anti-tumor immune
-A paracentesis or thoracentesis is often done for symptomatic relief from the malignant
-To obtain blood samples and ascites and pleural effusion samples from patients with solid
tumor malignancies, with the intent of performing translational studies related to cancer.
Patients greater than or equal to 18 years of age.
Diagnosis of malignant solid tumor.
Patients must be able and willing to provide informed consent.
-We will collect approximately 200cc-5L ascites from patients that are undergoing a
therapeutic paracentesis or thoracentesis. No thoracentesis or paracentesis will be
performed solely for research purposes.
-The fluid will be collected during the medical procedure and may be collected at more
than one time point.
-We will also collect 30ml of peripheral blood. This will be from patients who are being
seen in follow up, consultation, or presenting for enrollment on a clinical trial.
Participants greater than or equal to 18 years of age with histologically proven malignant solid tumors
Ability and willingness to provide informed consent to participation.
Participants with malignant solid tumors with a clinical indication for a thoracentesis or paracentesis.
-Children < 18 years of age are not eligible.
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There is 1 Location for this study
Bethesda Maryland, 20892, United States
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