Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines

Inclusion Criteria:

Patients must have advanced stage (III-IV) epithelial carcinoma of ovarian, tubal, or peritoneal origin.

Histologic documentation of the original primary tumor is required via the pathology report.
Original tumor blocks from primary diagnosis biopsy will be reviewed by our study pathologist at Magee.
Patients must be receiving neoadjuvant chemotherapy
Patients must be eligible for cancer-related definitive therapy with neoadjuvant chemotherapy
Patients must be chemonaive and receiving therapy in primary first line neoadjuvant setting
Patients must have GOG performance of 0-1
Patients must be reasonable candidates for interval debulking surgery as well as IP platinum based combination chemotherapy regimen with no prior evidence of clinically significant intra-abdominal adhesions, persistent abdominal wall infections, renal toxicity, or bowel obstruction.
Patients of childbearing potential must have a negative pregnancy test prior to the study entry and be practicing an effective form of contraception. If applicable, patients must discontinue breastfeeding prior to the first date of treatment on this study.
Patient must be willing to undergo leukapheresis
Patients must agree to appropriate clinical monitoring to receive the study regimens.

Patient must have:

Bone marrow function:
Absolute neutrophil count (ANC) greater than or equal to 1,500/µL, equivalent to CTCAE v4 grade 1.
Platelets greater than or equal to 100,000/µL;
hemoglobin greater than or equal to 8.0 g/dL.

Renal function:

creatinine less than or equal to 1.5 x institutional upper limit normal (ULN), CTCAE v4 grade 1.

Hepatic function:

Bilirubin less than or equal to 1.5 x ULN (CTCAE v4 grade 1).
SGOT and alkaline phosphatase less than or equal to 2.5 x ULN (CTCAE v4 grade 1).
Patients who have signed informed consent and authorization permitting release of personal health information.
Patients must have a GOG Performance Status of 0 or 1.
Exclusion Criteria:
Patients who have an active autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus (SLE), ulcerative colitis, Crohn's Disease, multiple sclerosis (MS), ankylosing spondylitis).
Patients with a known allergy to cisplatin or taxane chemotherapy. Patients with carboplatin allergy may be included if they tolerate a test dose of IV cisplatin given in monitored floor conditions. Patients who are allergic to paclitaxel, can be alternatively treated with abraxane.
Patients being chronically treated with immunosuppressive drugs such as cyclosporin, adrenocorticotropic hormone (ACTH), or systemic corticosteroids.
Patients with a recognized immunodeficiency disease including cellular immunodeficiencies, hypogammaglobulinemia or dysgammaglobulinemia; patients who have acquired, hereditary, or congenital immunodeficiencies.
Patients with uncontrolled diseases other than cancer will be excluded.
Patients who are pregnant or nursing.
Patients who have contraindications to the use of NSAID's like chronic renal failure, coronary artery disease, or bleeding ulcers.
Patients with tumors of low malignant potential, except ovarian pseudomyxoma or with no peritoneal disease.
Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are excluded if there is any evidence of other malignancy being present within the last five years. Patients are also excluded if their previous cancer treatment contraindicates this protocol therapy.
Patients with previous pelvic radiation therapy.