Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis From Colorectal, Appendiceal, Small Bowel, Gastric, Cholangiocarcinoma, Breast, Ovarian, or Other Gynecologic Primary Cancer

INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria.

Histological confirmation of non-mucinous peritoneal carcinomatosis from colorectal, appendiceal, small bowel, gastric, cholangiocarcinoma, breast, ovarian, or other gynecologic (i.e., endometrial, fallopian tube, primary peritoneal, cervical) primary by the Laboratory of Pathology, NCI.
Participants must have been treated with at least one line of approved systemic chemotherapy, with demonstrated resistance or lack of response
Measurable or evaluable disease as defined by RECIST v1.1. criteria and/or by Peritoneal Carcinomatosis Index (PCI)
Participants must be assessed to not be candidates for cytoreductive surgery, with PCI score > 30 on screening laparoscopy or with extensive small bowel serosal involvement
Age >= 18 years
ECOG performance status <= 2 (Karnofsky >= 60%).

Participants must have adequate organ and marrow function as defined below:

Leukocytes >= 3,000/mcL
Absolute neutrophil count >= 1,000/mcL
Platelets >= 100,000/mcL
Total bilirubin within <= 1.5x institutional upper limit of normal (ULN)
AST (SGOT)/ ALT (SGPT) <= 2.5x institutional ULN
Serum amylase and lipase <= 1.5x institutional ULN
Serum potassium and magnesium greater than institutional lower limit of normal
Creatinine <= 1.5 mg/dL or creatinine clearance >= 60 mL/min/1.73 m2 for participants with creatinine levels above institutional normal calculated using eGFR
Breastfeeding participant must agree to discontinue breastfeeding.
Females of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and for 90 days after last study treatment. Should a female suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately.
Ability of participant to understand and the willingness to sign a written informed consent document.
Participants must agree to co-enrollment on the tissue collection protocol 13C0176, Tumor, Normal Tissue and Specimens from Patients Undergoing Evaluation or Surgical Resection of Solid Tumors

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study.

Participants who are receiving any other investigational agents or has received an investigational agent within 30 days prior to the start of study treatment.
History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs.
Participants who have received systemic (i.e., oral or intravenous) chemotherapy within 5 half-lives of the individual agent(s) administered or who have undergone major surgery within the last 12 weeks prior to the start of study treatment.
Previous intraperitoneal chemotherapy within the last 6 months.
Participants requiring the use of drugs known to prolong the QT interval or known to strongly inhibit CYP3A4, 2C8. Participants on such agents at the time of screening are permitted on study if an alternative that does not have the same pharmacokinetic interactions can be found.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. Note: No subject will be excluded based on a social situation prior to consultation with the Department of Social Work.
Pregnant women are excluded from this study.
Patients with HIV who have detectable viral load, or whose ART contains QTc Prolonging Medications or CYP3A4 Inhibitors regardless of viral load. (NOTE: Patients with HIV who have an undetectable viral load and have been on stable doses of ART that does not prolong the QT interval or is a strong CYP3A4, 2C8 inhibitor are eligible).
QTcF interval of >= 450 msec at study entry, or congenital long QT syndrome.
More than 3 liters of ascites present at initial laparoscopy, or history of more than two paracentesis procedures in the 30 days prior to initial laparoscopy.
Advanced hepatic failure, as indicated by Child-Pugh Class C cirrhosis.
Sensory/motor neuropathy >= Grade 2