Ovarian Cancer Clinical Trial
Ovarian Tissue Transplantation
Summary
Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol 806062). The primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.
Eligibility Criteria
Inclusion Criteria:
Female patient between the ages of 18 and 45 years
Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
Ovarian insufficiency defined as an elevated FSH over 10
Inability to conceive after 6 months of unprotected intercourse with male
Reasonably good health
Candidate for pregnancy
Written clearance for the procedure from the patients oncologist
Exclusion Criteria:
Patients considered to be high risk for surgical complications will be excluded from the research protocol
Women who are known to be positive for the BRCA mutation
Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
Current pregnancy
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There is 1 Location for this study
Philadelphia Pennsylvania, 19104, United States More Info
Principal Investigator
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