Preservation of Ovarian Function After Hematopoietic Cell Transplant

Inclusion Criteria:

Interventional Arm:

Eligible for myeloablative allogenic or autologous hematopoietic cell transplant (HCT)
Post-menarchal female < or = 50 years of age
Normal antimullerian hormone (AMH) level and/or follicle stimulating hormone (FSH)/leuprolide (LH) levels for age/stage of puberty
Those women who have an FSH > 40 IU/L and whose diagnosis of malignancy and whose chemotherapy treatment was within 12 weeks of enrollment are still eligible if they had normal menstrual cycles pre-diagnosis.

Observational Arm:

Eligible for reduced intensity allogeneic HCT
Post-menarchal female ≤ 50 years of age
Normal AMH level and/or FSH/LH for age/stage of puberty
Those women who an FSH >40 IU/L and whose diagnosis of malignancy and chemotherapy treatment was within 12 weeks of enrollment are still eligible if they had normal menstrual cycles pre-diagnosis.

Exclusion Criteria:

All Arms:

History of ovarian cancer
Surgical resection of one or both ovaries. Prior hysterectomy is allowed as long as the ovaries are intact.
Use of GnRH agonist in last 12 months will exclude patients if lab results are not available to demonstrate adequate ovarian function prior to initiation of GnRH therapy.