Ovarian Cancer Clinical Trial
Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer
This is a single arm pilot trial to evaluate the feasibility of using a simvastatin intervention, and to evaluate its effects on cancer progression, among 20 patients with platinum-sensitive ovarian cancer, treated with carboplatin and liposomal doxorubicin at Cedars-Sinai Medical Center.
This is a pilot study of statin therapy to examine the feasibility of simvastatin use to reduce disease progression in 20 patients with platinum-sensitive ovarian cancer at Cedars-Sinai Medical Center. This study will focus on patients with recurrent platinum sensitive ovarian cancer to increase the likelihood that this population will experience recurrent disease during the 6-month intervention and follow-up. In addition, this population of patients has a narrow range of standard of care carboplatin doublet combinations that are prescribed, enabling the investigators to create a more homogenous study population. Given their high risk of developing recurrent disease, women with platinum sensitive ovarian cancer, have the potential to derive the maximum benefit from an intervention that could delay disease progression and enhance survival.
Recurrent platinum sensitive ovarian cancer, all histologies (serous, endometrioid, mucinous, clear cell). Platinum sensitivity defined as ≥ 6 months since last platinum treatment.
No contraindication to carboplatin and/or liposomal doxorubicin or simvastatin.
Prior or current use of any statin medication
Current systemic use of medications known to interact with statins
Current use of any other investigational agents
Liver disease, active cirrhosis
Uncontrolled intercurrent illness
History of chronic myopathy
Prior cancer other than ovarian cancer or non-melanomatous skin cancers
Known active infection with HIV
Current excessive alcohol consumption (average alcohol consumption of more than 5 drinks per day)
Prior exposure to doxorubicin or liposomal doxorubicin
Hemoglobin A1C >8.0%
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There is 1 Location for this study
Los Angeles California, 90048, United States More Info
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