Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

Key Inclusion Criteria:

Ovarian Cancer Cohorts Only: Patients with histologically or cytologically confirmed diagnosis of advanced, epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer who have all of the following:

serum CA-125 level ≥2 x upper limit of normal (ULN) (in screening)
has received at least 1 line of platinum-containing therapy or must be platinum-intolerant (applicable for dose escalation and non-randomized dose expansion cohorts)
documented relapse or progression on or after the most recent line of therapy
no standard therapy options likely to convey clinical benefit
Adequate organ and bone marrow function as defined in the protocol
Life expectancy of at least 3 months
Randomized phase 2 expansion cohort (Ovarian Cancer only): Platinum-resistant ovarian cancer patients who have had 1 to 3 lines of platinum-based therapy as defined in the protocol.

Endometrial Cancer Cohorts Only: histologically confirmed endometrial cancer that has progressed or recurrent after prior anti-Programmed Cell Death Ligand 1 (PD-1) therapy and platinum-based chemotherapy:

MUC16 positivity of tumor cells ≥25% by immunohistochemistry (IHC)
1-2 prior lines of systemic therapy

Key Exclusion Criteria:

Prior treatment with anti-Programmed Cell Death (PD-1)/PD-L1 therapy, as described in the protocol
Ovarian Cancer Expansion cohorts only: More than 4 prior lines of cytotoxic chemotherapy
Prior treatment with a MUC16 - targeted therapy
Untreated or active primary brain tumor, central nervous system (CNS) metastases, or spinal cord compression, as described in the protocol
History and/or current cardiovascular disease, as defined in the protocol
Severe and/or uncontrolled hypertension at screening. Patients taking anti-hypertensive medication must be on a stable anti-hypertensive regimen

Note: Other protocol Inclusion/Exclusion Criteria apply