Ovarian Cancer Clinical Trial

Study to Evaluate Immune Responses in Neurologically Normal Cancer Patients

Summary

The purpose of this study is to study whether immune cells capable of killing tumors that express proteins associated with paraneoplastic neurologic syndrome (PNS) can be found in small cell lung cancer and ovarian cancer patients. The presence of these cells may play a role in tumor immunity in these patients. The protocol involves neurological examinations and collection of blood.

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Full Description

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Eligibility Criteria

Inclusion Criteria:

Males and females ages 25 -75

If leukapheresis:

Hepatitis B surface antigen negative if tested* Hepatitis C antibody negative if tested* HIV antibody negative if tested* Venereal disease reaction level (VDRL) negative if tested* No known IV drug users Hemoglobin > 8.5 White blood cell count > 3,800 Platelets > 120,000 International normalized ratio (INR) < 2 (verified only if clinically indicated)

If large blood draw (1/2 to 1 unit) in lieu of leukapheresis:

Hepatitis B surface antigen negative if tested* Hepatitis C antibody negative if tested* HIV antibody negative if tested* VDRL negative if tested* No known IV drug users HgB > 10.0 WBC > 3,800 Platelets > 120,000 INR < 2 (verified only if clinically indicated)

Exclusion Criteria:

No known neurologic disease 2. No known central nervous system (CNS) metastasis on clinical exam 3. No chemotherapy within 1 month 4. No New York Heart Association class III/IV status 5. No pulmonary disease which limits daily activities 6. No anticoagulation therapy

Study is for people with:

Ovarian Cancer

Estimated Enrollment:

33

Study ID:

NCT00481637

Recruitment Status:

Completed

Sponsor:

Rockefeller University

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There is 1 Location for this study

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Rockefeller University Hospital
New York New York, 10021, United States

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Study is for people with:

Ovarian Cancer

Estimated Enrollment:

33

Study ID:

NCT00481637

Recruitment Status:

Completed

Sponsor:


Rockefeller University

How clear is this clinincal trial information?

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