Ovarian Cancer Clinical Trial
The Role of Cytomegalovirus and Inflammation on Patient Symptoms and Outcomes in Ovarian Cancer
Summary
Cytomegalovirus (CMV), a widely prevalent virus in the general US population, has been shown to be associated with increased inflammation and mortality. Previous small pilot studies have demonstrated that latent CMV may be reactivated during chemotherapy in cancer patients, and may be associated with unfavorable cancer outcomes such as fatigue and increased mortality.
The central research idea for this study, supported by previous preliminary data, is that CMV reactivation is an unrecognized complicating factor in the treatment of ovarian cancer that impacts patient outcomes. The overarching goals of this observational study are:
To assess how CMV infection is associated with ovarian cancer symptoms over the course of the disease and its treatment.
To describe the relationship between CMV reactivation in ovarian cancer patients, survival, fatigue, and other QOL outcomes, both cross-sectionally and longitudinally.
Eligibility Criteria
Inclusion Criteria:
Age ≥18
Ability to read and write in English
women with newly diagnosed with ovarian, primary peritoneal, or fallopian tube cancer
Treatment plan includes chemotherapy
Able to provide written voluntary consent before performance of any study related procedure.
Cohort 1 only: within 2 years of completing initial chemotherapy treatment
Cohort 2 only: prior to starting chemotherapy
Exclusion Criteria:
Inability to provide informed written consent
Previous exposure to chemotherapy
Life expectancy < 3 months or in hospice care or nursing home
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There is 1 Location for this study
Minneapolis Minnesota, 55455, United States
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