Trial of Liposomal Doxorubicin (Doxil) and Weekly Docetaxel (Taxotere)

Inclusion Criteria:

Histological proof of advanced or recurrent solid tumor which has failed prior therapy, or for which no effective therapy is available.
Ovarian cancer patients (or primary peritoneal carcinoma) whose only manifestation of disease is an elevated cancer antigen (CA) 125 of > 100 are eligible.
SWOG performance status 0-2.
Absolute granulocyte count (AGC) greater than or equal to 1.5; platelets greater than or equal to 100,000.
Total bilirubin less than or equal to the upper limit of normal (ULN).
Transaminases (SGOT and/or SGPT) may be up to 2.5 x institutional upper limit of normal (ULN) if alkaline phosphatase is <= ULN, or alkaline phosphatase may be up to 4 x ULN if transaminases are <= ULN. However, patients who have both transaminase elevation > 1.5 x ULN and alkaline phosphatase > 2.5 x ULN are not eligible for this study (due to decreased clearance of docetaxel and increased risk of toxicity).
Age greater than or equal to 18 years.
Fully recovered from acute toxicities from chemotherapy, radiation, or surgery.
Negative serum pregnancy test, if patient is female, still fertile, and sexually active.

Exclusion Criteria:

Prior treatment with Doxil or weekly docetaxel. Prior docetaxel administered every 3 weeks is allowed.
Evidence of moderate peripheral neuropathy greater than or equal to grade 2.
Medical, social, or psychological factors interfering with compliance.
Known history of cardiac disease (congestive heart failure, coronary artery disease) that would preclude treatment with Doxil in the opinion of the investigator.
Cardiac ejection fraction < 50%
Pregnancy