Prostate Cancer Clinical Trial

A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors

Summary

This is a Phase 1, open-label study to explore the safety, tolerability, and preliminary clinical activity of agenT-797, an unmodified, allogeneic iNKT cell therapy, in participants with relapsed/refractory (r/r) solid tumors, as well as define the recommended phase II dose in solid tumors. This Phase 1 study will also explore the safety, tolerability, and preliminary clinical activity of agenT-797 in combination with approved immune checkpoint inhibitors (ICIs), including pembrolizumab and nivolumab, in participants with r/r solid tumors.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histological or cytological evidence of relapsed or refractory solid tumor malignancy for which no standard therapy is available or standard therapy has failed
Measurable disease per RECIST 1.1 as assessed by local site Investigator/radiology. Lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions
Part 2 only, participants must have progressed per Investigator assessment on pembrolizumab or nivolumab, and agree and are able to continue on the inhibitor(s) while on study
No other medical, surgical, or psychiatric condition (including active substance abuse) that would interfere with compliance to the protocol, as determined by the Principal Investigator

Exclusion Criteria:

Concurrent invasive malignancy
Brain and/or leptomeningeal metastases that are untreated or require current therapy
Prior radiotherapy within 2 weeks of start of study treatment

Study is for people with:

Prostate Cancer

Phase:

Phase 1

Estimated Enrollment:

30

Study ID:

NCT05108623

Recruitment Status:

Recruiting

Sponsor:

MiNK Therapeutics

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There are 9 Locations for this study

See Locations Near You

University of Southern California
Los Angeles California, 90033, United States More Info
Michael Haas
Contact
312-505-9500
[email protected]
Anthony El-Khoueiry, MD
Principal Investigator
University of Colorado
Aurora Colorado, 80045, United States More Info
Dan Nguyen
Contact
[email protected]
Breelyn Wilky, MD
Principal Investigator
Norton Cancer Health
Louisville Kentucky, 40241, United States More Info
Ben Orem
Contact
502-629-2500
John Hamm, MD
Principal Investigator
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02215, United States More Info
Denise Graham
Contact
[email protected]
David Einstein, MD
Principal Investigator
Weill Cornell Medicine
New York New York, 10022, United States More Info
Helen Barkhudarayan
Contact
646-962-8215
[email protected]
Koen van Besien, MD
Principal Investigator
University of Cincinnati Cancer Center
Cincinnati Ohio, 45267, United States More Info
Madison Duan
Contact
513-584-7824
[email protected]
Trisha Wise-Draper, MD
Principal Investigator
Providence Portland Medical Center
Portland Oregon, 97213, United States More Info
An Nguyen
Contact
425-224-7602
[email protected]
Rachel Sanborn, MD
Principal Investigator
LifeSpan - Rhode Island Hospital
Providence Rhode Island, 02903, United States More Info
Ginal Johnson
Contact
401-444-4226
[email protected]
Benedito Carneiro, MD
Principal Investigator
Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States More Info
Nurse Navigator Team
Contact
615-329-7274
Benjamin Garmezy, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Prostate Cancer

Phase:

Phase 1

Estimated Enrollment:

30

Study ID:

NCT05108623

Recruitment Status:

Recruiting

Sponsor:


MiNK Therapeutics

How clear is this clinincal trial information?

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