Prostate Cancer Clinical Trial

Assess the Safety, Tolerability, PK and Anti-tumor Efficacy of DZD2269 in Patients With MCRPC

Summary

This study will treat patients with Metastatic Castration Resistant Prostate Cancer who have progressed following prior therapy. This is the first time this drug has ever been tested in patients, and so it will help to understand what type of side effects may occur with the drug treatment. It will also measure the the levels of drug in the body and preliminarily assess its anti-cancer activity as monotherapy.

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Full Description

A first-time-in-human, Phase I, open-label, multicenter study to determine safety, tolerability, pharmacokinetics, and preliminary anti-tumor activity of DZD2269 in patients with mCRPC.

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Eligibility Criteria

Inclusion Criteria:

Informed consent form, taken prior to any study specific procedures, sampling and/or analyses.
Male patients age ≥ 18 years (≥ 19 in S. Korea), ECOG status 0-1, Predicted life expectancy ≥ 12 weeks,
All patients enrolled must have histologically confirmed diagnosis of adenocarcinoma of the prostate, with metastatic disease, and must also previously progressed on standard-of-care (SoC) therapy (i.e., abiraterone or enzalutamide, taxanes such as docetaxel or cabazitaxel) despite castrate levels of testosterone.
Be willing to provide blood samples and paired tumor tissue (if accessible) for the exploratory biomarker research
Total testosterone < 50 ng/dL at screening (except for subjects with prior orchiectomy, where testosterone does not need to be measured).
Adequate bone marrow reserve and organ system functions
LVEF ≥ 55% assessed by ECHO or MUGA

Exclusion Criteria:

Cytotoxic chemotherapy from a previous treatment regimen within 21 days of the first dose of study treatment.
Major surgery procedure (excluding placement of vascular access), or significant traumatic injury within 4 weeks of the first dose of study treatment, or have an anticipated need for major surgery during the study.
Prior exposure to therapeutic anticancer vaccines
Prior immune-mediated therapy including, but not be limited to, anti-CTLA-4, anti-PD1, anti-PDL1 and anti-PDL2 must have a wash-out period of ≥ 30 days before dosing
Prior/concomitant therapy with any other A2aR antagonist.
Live vaccines within 28 days prior to first dose.
Radiotherapy with a limited field for palliation within 1 week of the first dose of study treatment.
Patients currently receiving (or unable to stop using) medications or herbal supplements known to be potent inhibitors or inducers of CYP3A4, sensitive CYP3A4 substrates with narrow therapeutic index, and sensitive MATE1 and MATE2-K substrates with narrow therapeutic range
Any unresolved toxicities > Grade 1 (except alopecia).
Bone pain due to metastatic bone disease that cannot be managed with a routine, stable dose of a narcotic analgesic
Active infections as outlined in protocol
Spinal cord compression.
Patients who require systemic use of corticosteroids (at any dose)
Refractory nausea and vomiting if not controlled by supportive therapy
Cardiac criteria as outlined in protocol
Prior malignancy, except for adequately treated basal cell or squamous cell skin cancer or other cancer from which the patient has been disease free for ≥ 2 years or which will not limit survival to < 2 years

Study is for people with:

Prostate Cancer

Phase:

Phase 1

Estimated Enrollment:

16

Study ID:

NCT04634344

Recruitment Status:

Terminated

Sponsor:

Dizal Pharmaceuticals

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There are 6 Locations for this study

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Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
University of Pittsburgh Medical Center
Pittsburgh Pennsylvania, 15215, United States
Severance Hospital
Seoul , 03722, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Samsung Medical Center
Seoul , 06351, Korea, Republic of
The Catholic University of Korea - Seoul St. Marys Hospital
Seoul , 06591, Korea, Republic of

How clear is this clinincal trial information?

Study is for people with:

Prostate Cancer

Phase:

Phase 1

Estimated Enrollment:

16

Study ID:

NCT04634344

Recruitment Status:

Terminated

Sponsor:


Dizal Pharmaceuticals

How clear is this clinincal trial information?

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