Fluorine F 18 Sodium Fluoride Positron Emission Tomography in Evaluating Response to Dasatinib in Patients With Prostate Cancer and Bone Metastases

Inclusion Criteria:

Must be able to provide a written informed consent
Men 18 years or older with metastatic castration-resistant prostate cancer enrolling onto the Febbo clinical trial with dasatinib therapy (must meet all inclusion criteria for dasatinib treatment study and comply with requirements of that specific clinical trial)
Histologic confirmation of original prostate cancer diagnosis
Presence of at least one convincing bone metastasis as defined by bone scintigraphy, computed tomography (CT) scan (magnetic resonance imaging [MRI] if indicated), or plain X-ray
Must currently have castrate testosterone levels (< 50 ng/dL) from orchiectomy or maintenance on a luteinizing hormone-releasing hormone (LHRH) agonist or LHRH antagonist

Exclusion Criteria:

On the nilutamide-only arm (Arm A of the clinical therapeutic trial)

Note: However, if a patient crosses-over from nilutamide at the time of progression to add dasatinib therapy, he may be eligible for 18F-fluoride PET imaging protocol if he meets all inclusion criteria for this trial
Any condition that would alter the patient's mental status, prohibiting the basic understanding and/or authorization of informed consent
A serious underlying medical condition that would otherwise impair the patient's ability to receive treatment and imaging studies
Expected lifespan of 12 weeks or less
Extremely poor intravenous access, prohibiting the placement of a peripheral IV line for injection of radiotracer
Initiation of bisphosphonate therapy less than 4 weeks from the first PET scan
Radiation treatment to bone less than 4 weeks from first PET scan
Radiopharmaceutical treatment to bone less than 4 weeks from first PET scan
Treatment with granulocyte-macrophage colony stimulating factor (GM-CSF) or granulocyte CSF (G-CSF) within 4 weeks prior to first PET scan
Inability to lie still for the imaging
Weight > 300 lbs. (due to equipment specifications)