Prostate Cancer Clinical Trial
MRI Screening in Men at High Risk of Developing Prostate Cancer
Summary
The purpose of this study is to determine whether or not Magnetic Resonance Images (MRI) will identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer.
Full Description
In this study the study team hypothesizes MR images will identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer. Subjects will receive gadolinium (intravenous contrast agent) as part of their research MRI exam. While the deposition of gadolinium (Gd) has been demonstrated in numerous studies, the clinical consequences of Gd deposition are unknown. Gd enhanced MRI scans provide crucial medical information regarding prostate and prostate cancer imaging and contrast-enhanced images are a component of all guidelines and the PIRADS scoring system. The study team will compare baseline prostate MR images of men at high risk of developing prostate cancer to those without an identifiable predisposition and evaluate the role of a GRS in screening men with at elevated risk of being diagnosed with prostate cancer.
Eligibility Criteria
Inclusion Criteria:
Male age 18 and older
No known history of prostate cancer
No previous prostate resection or ablation (e.g. TURP, photovaporization)
Exclusion Criteria:
Unable to tolerate MRI due to metal fragments or claustrophobia
Lack of a rectum
Hip arthroplasty
Prostate biopsy done within last 3 years
Prostate MRI done within last 3 years
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