Prostate Cancer Clinical Trial

Prostate Cancer Genetic Literacy and Patient-Caregiver Communication

Summary

With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions. This study is designed to investigate the understanding of prognostic genetic technology and patient-caregiver communication in African American and rural White men with localized prostate cancer.

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Full Description

Novel genomic technology, such as microarray analyses and next-generation sequencing, have improved the understanding of prostate cancer biology and prognosis. The National Comprehensive Cancer Network (NCCN), in 2016, recommended that patients and clinicians consider tissue-based genetic tests for localized prostate cancer. However, while much enthusiasm currently exits for the rapidly increasing field of genomic medicine, the use of multi-gene mRNA expression panels raises the potential for further divergence in prostate cancer treatment outcomes by race and low socioeconomic status. We know that health disparities persist in low income groups despite the existence of evidence-based guidelines and that adoption of state-of-the-art methods often lag behind in these groups.

The goals of this study are to (1) explore how men with localized prostate cancer and their caregivers comprehend prognostic genetic technology, and (2) examine how an educational video about genetics impacts patient-caregiver communication of prognostic genetic technology. The study rationale is that without direct attention to genomic comprehension, the enthusiasm that exists in the rapidly increasing field of prostate cancer genomic medicine may not translate into health benefits for men with localized prostate cancer. The central hypotheses are (1) men and caregivers with lower levels of education will demonstrate a severe lack of genomic comprehension of tissue-based genetic tests for localized prostate cancer; and (2) tailored prostate cancer education, communication coaching, and a genomic literacy educational video will significantly improve patient-caregiver communication in a low literacy population.

The study approach is innovative because it applies a mixed-methods community-engagement research framework to explore how African American and rural White men with localized prostate cancer, comprehend and interpret data generated from genetic technology. The proposed research is significant because of its potential to improve public health by (1) improving the understanding of prognostic genetics in minority, low income, and rural populations, and (2) engage and educate these diverse communities about genomics.

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Eligibility Criteria

Inclusion Criteria:

Localized prostate cancer (stage 1 and 2)
Age 40 and older
Male
Able and willing to provide informed consent
English-speaking
Willing to participate in the study

Exclusion Criteria:

Men with metastatic prostate cancer
Plan to move out of the area within the next 12 months
Severe persistent mental illness such as dementia

Study is for people with:

Prostate Cancer

Estimated Enrollment:

260

Study ID:

NCT04550845

Recruitment Status:

Recruiting

Sponsor:

University of Georgia

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There is 1 Location for this study

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University of Georgia
Athens Georgia, 30602, United States More Info
Ewan K Cobran, PhD
Contact
706-542-5327
[email protected]
Ewan K Cobran, PhD
Principal Investigator

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Study is for people with:

Prostate Cancer

Estimated Enrollment:

260

Study ID:

NCT04550845

Recruitment Status:

Recruiting

Sponsor:


University of Georgia

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