Prostate Cancer Clinical Trial
Study of CEP-701 in Treatment of Prostate Cancer
Summary
The purpose of this study is to determine the proportion of patients with a serological prostate specific antigen (PSA) by day 85.
Full Description
A serological PSA response is defined as a reduction from baseline PSA serum concentration of at least 50%, which is confirmed by a second PSA value 28 or more days later.
Eligibility Criteria
Inclusion Criteria:
at least 18 yrs of age
diagnosis of adenocarcinoma of the prostate
no detectable metastatic disease as assessed by bone and CT scans
has increasing serum PSA concentrations
life expectancy of at least 3 months
ECOG of 0 or 1
has been withdrawn from antiandrogen therapy for at least 6 weeks prior to entering screening period
Exclusion Criteria:
has asymptomatic disease
has active GI ulceration or bleeding
has been treated with non-hormonal systemic anticancer therapy or has received radiation within 4 weeks of baseline visit
bilirubin >2x ULN or ALT or AST >2xULN or serum creatinine >1.5mg/dL
hemoglobin <9g/dL or platelets below 100,000/uL or ANC below 1500/uL
receiving treatment for HIV with protease inhibitors
has had prior malignancy within past 5 yrs with exception of resected basal or squamous cell carcinomas of the skin
has used investigational drug with previous one month
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There is 1 Location for this study
Baltimore Maryland, 21287, United States
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