Prostate Cancer Clinical Trial

Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications

Summary

This is a first-in-human, multi-center, open-label clinical study with separate dose escalation (Phase 1) and expansion (Phase 2) stages to assess preliminary safety, tolerability, and efficacy of the second generation oral XPO1 inhibitor KPT-8602 in participants with relapsed/refractory multiple myeloma (MM), metastatic colorectal cancer (mCRC), metastatic castration resistant prostate cancer (mCRPC), higher risk myelodysplastic syndrome (HRMDS), acute myeloid leukemia (AML) and newly diagnosed intermediate/high-risk MDS.

Dose escalation and dose expansion may be included for all parts of the study as determined by ongoing study results.

View Eligibility Criteria

Eligibility Criteria

INCLUSION CRITERIA

Written informed consent signed prior to any screening procedures and in accordance with federal, local, and institutional guidelines.
Age ≥ 18 years.

Adequate hepatic function:

total bilirubin ≤ 2 times the upper limit of normal (ULN) (except participants with Gilbert's syndrome [hereditary indirect hyperbilirubinemia] who must have a total bilirubin of ≤ 4 times ULN),
aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 times ULN (except participants with known liver involvement of their tumor who must have their AST and ALT ≤ 5.0 times ULN).
Adequate renal function: estimated creatinine clearance of ≥ 30 mL/min, calculated using the formula of Cockcroft and Gault (140-Age) × Mass (kg)/(72 × creatinine mg/dL); multiply by 0.85 if female.

Contraception:

Participants with RRMM, CRC, RR high-risk MDS (Part F Phase 2), and AML (Part H): Female participants of child-bearing potential must agree to use dual methods of contraception (including 1 highly effective and 1 effective method of contraception) and have a negative serum test at Screening, and male participants must use an effective barrier method of contraception if sexually active. For both male and female participants, effective methods of contraception must be used throughout the study and for 3 months following the last dose
Participants with RR mCRPC: Participants must use an effective barrier method of contraception if sexually active. Effective methods of contraception must be used throughout the study and for 3 months following the last dose
Participants with newly diagnosed intermediate/high-risk MDS (Part G): Female participants of child-bearing potential must agree to use dual methods of contraception (including 1 highly effective and 1 effective method of contraception) and have a negative serum pregnancy test at Screening, and male participants must use an effective barrier method of contraception if sexually active. For both male and female participants, effective methods of contraception must be used throughout the study and for 6 months following the last dose

INDICATION-SPECIFIC INCLUSION CRITERIA

Relapsed/Refractory Multiple Myeloma (Parts A1, A2, and B - Completed):

Symptomatic, histologically confirmed MM and evidence of disease progression, based on IMWG guidelines.

Participants must have measurable disease as defined by at least 1 of the following:

Serum M-protein ≥ 0.5 g/dL by serum protein electrophoresis (SPEP) or for immunoglobulin (Ig) A myeloma, by quantitative IgA. If SPEP is felt to be unreliable for routine M-protein measurement (e.g., for participants with IgA MM), then quantitative Ig levels by nephelometry; or
Urinary M-protein excretion at least 200 mg/24 hours; or
Serum free light chain (FLC) whereby the involved light chain measures ≥ 10 mg/dL and with an abnormal ratio.
Previously treated with ≥ 3 prior regimens (lines of therapy) that included at least 1 of each of the following: an immunomodulatory drug, a proteasome inhibitor, and a steroid.
MM refractory to the participants most recent anti-MM regimen.
Participants receiving hematopoietic growth factor support including erythropoietin, darbepoetin, granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor, and platelet stimulators can continue to do so, but must be transfusion independent for at least 1 week prior to Cycle 1 Day 1 (C1D1) in the study.
Adequate hematopoietic function: total white blood cell (WBC) count ≥ 1500/mm^3, absolute neutrophil count (ANC) ≥ 800/mm^3, hemoglobin (Hb) ≥ 8.0 g/dL, and platelet count ≥ 75,000/mm^3.
Eastern Cooperative Oncology Group (ECOG) performance status of ≤1.

Life expectancy of ≥ 4 months.

Relapsed/Refractory Colorectal Cancer (Part C - Completed):

Histological or cytological documentation of adenocarcinoma of the colon or rectum.
Measurable disease by RECIST v1.1.
Metastatic disease not suitable for upfront curative-intent surgery.
Participants with site-defined KRAS status (wild-type or mutant) from a fresh or archival tumor biopsy prior to enrollment. All participants must be willing to have fresh biopsies to obtain tumor tissue for biomarker analysis.
Documented evidence of progressive disease according to RECIST v1.1.

Prior treatment (with completion of a course of therapy, or to disease progression or intolerability) with each of the following:

Fluoropyrimidine-, oxaliplatin-, irinotecan-based chemotherapies (e.g., FOLFOX and/or FOLFIRI)
if KRAS wild-type, an anti-EGFR therapy,
Prior third line treatment with regorafenib or TAS-102, will be assessed on an individual basis,
Note: The requirement for prior third line regorafenib will be assessed on an individual basis by the investigator in consultation with the Karyopharm Medical Monitor
Radiation and surgery are not considered as prior anticancer regimens
Participants should not be transfusion dependent.
Adequate hematopoietic function: ANC ≥ 1000/mm^3, hemoglobin (Hb) ≥ 9.0 g/dL, and platelet count ≥ 100,000/mm^3.
ECOG performance status of ≤ 1.

Life expectancy of ≥ 4 months.

Relapsed/Refractory Metastatic Castration-resistant Prostate Cancer (Parts D and E - Completed):

Histologically confirmed adenocarcinoma of the prostate with archival tumor tissue available for molecular analyses. If the participants does not have a prior histological diagnosis, then a fresh biopsy at Screening may be used for this purpose.

a. Optional: All participants will be asked to have fresh biopsies to obtain tumor tissue for biomarker analysis.

Surgically or medically castrated, with testosterone levels of < 50 ng/dL (< 2.0 nM). If the participant is being treated with luteinizing hormone-releasing hormone (LHRH) agonists (participants who have not undergone orchiectomy), and participants must have shown to progress on this.

Documented mCRPC progression as assessed by the Investigator with 1 of the following:

Prostate-specific antigen (PSA) progression defined by a minimum of 3 rising PSA levels (at approximately Day -30 and approximately Day -45) with an interval of > 1 week between each determination. The PSA values at the Screening visit should be > 2 μg/L (> 2 ng/mL); participants on systemic glucocorticoids for control of symptoms must have documented PSA progression by Prostate Cancer Working Group 3 (PCWG3) while on systemic glucocorticoids prior to commencing C1D1 of treatment.
Radiographic progression of soft tissue disease by modified RECIST criteria 1.1 or of bone metastasis with 2 or more documented new bone lesions on a bone scan with or without PSA progression.
Initial response (per modified PCWG3 Guidelines) to second generation anti-hormonal therapy (examples: abiraterone, enzalutamide, TAK 700), but later relapsed. Disease relapse would be defined as progressive disease at the time of entry per inclusion criterion 24.
Zero to 2 previous taxane-based chemotherapy regimens. If docetaxel chemotherapy is used more than once, this will be considered as 1 regimen. Participants may have had prior exposure to cabazitaxel treatment. Participants may be taxane naïve.
At least 2 weeks from completion of any radiotherapy including a single fraction of radiotherapy for the purposes of palliation (confined to 1 field) is permitted.
Participants should not be transfusion dependent.
Albumin > 2.5 g/dL.
Adequate hematopoietic function: ANC ≥ 1000/mm^3, hemoglobin (Hb) ≥ 9.0 g/dL, and platelet count ≥ 100,000/mm^3.
Part E only: Participants currently receiving treatment with abiraterone and appropriate to continue in the opinion of the Investigator. Participants must also have been on and continue on a stable dose of corticosteroids (prednisone or dexamethasone) for 30 days prior to C1D1.
ECOG performance status of ≤ 1.

Life expectancy of ≥ 4 months.

RR High-risk Myelodysplastic Syndrome (Part F Phase 2):

Documented diagnosis of MDS with 5% to 19% myeloblasts in the bone marrow (2016 WHO classification).
The marrow histopathology must be documented by recent bone marrow biopsy (within 30 days prior to C1D1).
IPSS-R: intermediate, high- or very-high-risk MDS.

RR MDS defined as having one of the following:

≥ 2 cycles of hypomethylating agents (azacitidine and/or decitabine, ASTX727, or experimental agents) with clear PD (pancytopenia with ≥ 50% increase in bone marrow blasts) or participant progressed to a higher risk category of MDS OR
≥ 4 cycles of HMA therapy with SD/lack of improvement (no CR/mCR/PR/HI) per International Working Group (IWG) 2006 criteria, or intolerance to treatment (≥ 6 cycles of azacitidine if required per local standard of care guidelines to establish lack of improvement/response to azacitidine) OR
Relapse or disease progression after an initial response to HMA (CR/mCR/PR/HI) per IWG 2006 criteria.
ECOG performance status of < 2.

Prior to enrolling a participant with imminent risk of AML transformation (per opinion of the Investigator) or for participants with RAEB-2 MDS, the Medical Monitor must be contacted.

Newly Diagnosed Intermediate/High-risk Myelodysplastic Syndrome (Part G):

Documented diagnosis of MDS with 5% to 19% myeloblasts in the bone marrow (2016 WHO classification)

a. The marrow histopathology must be documented in bone marrow biopsy (within 30 days prior to C1D1)

IPSS-R intermediate, high- or very-high-risk MDS.
No prior therapy for HR-MDS (up to one prior cycle of an HMA is allowed). Prior supportive care in the form of transfusions, growth factors, etc. is permitted.

ECOG performance status of < 2.

AML Maintenance (Post-alloSCT) Therapy (Part H):

Participants with de novo AML or AML secondary to prior myelodysplastic disease.
Received one allogeneic SCT (alloSCT).
Participants must be able to start study treatment between 40 and 100 days following alloSCT

Participants must be CR/CRi at the time of study enrollment, and must meet at least one of the following criteria:

MRD positive at time of enrollment
Evidence of disease pre-alloSCT (received alloSCT while not in CR/CRi, or while MRD positive)
In CR2 or greater pre-alloSCT (regardless of MRD status)
Adverse cytogenetics at time of diagnosis (regardless of MRD status) per ELN 2017 criteria
Adequate engraftment within 14 days prior to starting study therapy: absolute neutrophil count (ANC) ≥ 1.0 x 10^9/L without daily use of myeloid growth factor, and platelet count 75 x 10^9/L without platelet transfusion within 1 week.
ECOG performance status of ≤ 2

EXCLUSION CRITERIA

Participants in All Parts of the Study:

Female participants who are pregnant or lactating.
Major surgery within 4 weeks before C1D1.

Impaired cardiac function or clinically significant cardiac diseases, including any of the following:

Unstable angina or acute myocardial infarction ≤ 3 months prior to C1D1
Clinically significant heart disease (e.g., symptomatic congestive heart failure [e.g., > NYHA Class 2]; uncontrolled arrhythmia, or hypertension; history of labile hypertension or poor compliance with an antihypertensive regimen)
Uncontrolled active severe systemic infection requiring parenteral antibiotics, antivirals, or antifungals within 1 week prior to C1D1.
Participants with known symptomatic brain metastasis are not suitable for enrollment. Participants with asymptomatic, stable, treated brain metastases are eligible for study entry
Participants with a known history of human immunodeficiency virus (HIV); HIV testing is not required as part of this study
Known, active hepatitis A, B, or C infection; or known to be positive for HCV RNA or HBsAg (HBV surface antigen)

Prior malignancies:

Participants with adequately resected basal or squamous cell carcinoma of the skin, or adequately resected carcinoma in situ (i.e., cervix) may enroll irrespective of the time of diagnosis
Participants with relapsed/refractory MM, CRC, and mCRPC only: Prior malignancies which may interfere with the interpretation of the study. Cancer treated with curative intent < 5 years previously will not be allowed unless approved by the Sponsor. Cancer treated with curative intent > 5 years previously and without evidence of recurrence will be allowed.
For participants in Arms F Phase 2, G, and H: Prior malignancy is not an exclusion
Participants with gastrointestinal tract disease (or uncontrolled vomiting or diarrhea) that could interfere with the absorption of eltanexor (or ASTX727 in Part G).
Serious psychiatric or medical conditions that, in the opinion of the Investigator, could interfere with treatment, compliance, or the ability to give consent.

Participants unwilling to comply with the protocol including required biopsies and sample collections required to measure disease.

INDICATION-SPECIFIC EXCLUSION CRITERIA

Relapsed/Refractory Multiple Myeloma (RRMM) (Parts A1, A2 and B - Completed):

Time since the last prior therapy for treatment of RRMM:

Radiation, chemotherapy, immunotherapy or any other anticancer therapy, including investigational anticancer therapy ≤ 2 weeks prior to C1D1
Palliative steroids for disease related symptoms are allowed up to 3 days prior to C1D1.
Participants must have recovered or stabilized (≤ Grade 1 or to their baseline) from toxicities related to their previous treatment except for alopecia
Participants with active graft versus host disease after allogeneic stem cell transplantation. At least 3 months must have elapsed since completion of allogeneic stem cell transplantation.

Grade > 2 peripheral neuropathy or Grade 2 peripheral neuropathy with pain within 2 weeks prior to C1D1.

Relapsed/Refractory Colorectal Cancer (Part C - Completed):

Radiotherapy, chemotherapy, or any other anticancer therapy, including investigational anticancer therapy within 2 weeks prior to Screening. Participants must have recovered from clinically significant toxicities. The site of irradiation should have evidence of progressive disease (new lesions or increase in lesion size) if this is the only site of disease.

Participants who have been treated with their most recent chemotherapy or investigational drugs ≤21 days or 5 half-lives (whichever is longer) prior to the first dose of study treatment, and/or have any acute toxicities due to prior chemotherapy and/ or radiotherapy that have not resolved to a NCI CTCAE v4.03 Grade 0 or Grade 1 with the exception of chemotherapy induced alopecia and Grade 2 peripheral neuropathy.

Relapsed/Refractory Metastatic Castration-Resistant Prostate Cancer (Parts D and E - Completed):

Participants who have been treated with their most recent chemotherapy or investigational drugs ≤ 21 days or 5 half-lives (whichever is longer) prior to the first dose of study treatment, and/or have any acute toxicities due to prior chemotherapy and/ or radiotherapy that have not resolved to a NCI CTCAE v4.03 Grade 0 or Grade 1 with the exception of chemotherapy-induced alopecia and Grade 2 peripheral neuropathy.

Initiating bisphosphonate therapy or adjusting bisphosphonate dose/regimen within 30 days prior to C1D1. Participants on a stable bisphosphonate or denosumab regimen are eligible and may continue.

RR High-risk Myelodysplastic Syndrome (Part F Phase 2):

Very low or low-risk MDS per IPSS-R.
Evidence of transformation to AML by the World Health Organization (WHO) (≥ 20% blasts in bone marrow or peripheral blood).
Participants who are significantly below their ideal body weight as judged by the Investigator.

Any severe GVHD, or organ system dysfunction, which in the Investigator's opinion, could compromise the participant's safety.

Newly Diagnosed Intermediate/High-risk Myelodysplastic Syndrome (Part G):

IPSS-R very low or low-risk MDS.

Evidence of transformation to AML by the WHO (≥ 20% blasts in bone marrow or peripheral blood).

AML Maintenance (Post-alloSCT) Therapy (Part H):

Use of any anti-cancer maintenance therapy after alloSCT and prior to starting the study treatment
Active GVHD Grade 2 or higher.
Concurrent use of corticosteroids equivalent of prednisone at a dose > 0.5 mg/kg.

Study is for people with:

Prostate Cancer

Phase:

Phase 1

Estimated Enrollment:

277

Study ID:

NCT02649790

Recruitment Status:

Recruiting

Sponsor:

Karyopharm Therapeutics Inc

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There are 38 Locations for this study

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David Geffen School of Medicine at UCLA
Los Angeles California, 90095, United States More Info
Gary Schiller, MD
Contact
310-825-5513
[email protected]
Gary Schiller, MD
Principal Investigator
Oncology Institute of Hope and Innovation
Pasadena California, 91105, United States More Info
Amitabha Mazumder, MD
Contact
626-486-9447
[email protected]
Amitabha Mazumder, MD
Principal Investigator
Rocky Mountain Regional VA Medical Center
Aurora Colorado, 80045, United States More Info
Caitlin Hutchinson
Contact
720-857-5663
[email protected]
Maria Amaya
Principal Investigator
Sarah Cannon Cancer Center - (Colorado Blood Cancer Institute)
Denver Colorado, 80218, United States More Info
Alexandra Mandy
Contact
720-754-8065
[email protected]
Luke Mountjoy, MD
Principal Investigator
(USO) Rocky Mountain Cancer Centers
Littleton Colorado, 80120, United States More Info
Christopher Benton, MD
Contact
303-730-4700
[email protected]
Christopher Benton, MD
Principal Investigator
Moffitt Cancer Center
Tampa Florida, 33612, United States
Cancer and Hematology Centers of Western Michigan
Grand Rapids Michigan, 49503, United States More Info
Shannon Fabrie
Contact
616-954-5550
[email protected]
Brett Brinker, MD
Principal Investigator
Sarah Cannon Cancer Center (HCA Midwest KC)
Kansas City Missouri, 64132, United States More Info
Chris Baierl
Contact
816-276-9156
[email protected]
Suman Kambhampati, MD
Principal Investigator
Callahan Cancer Center
North Platte Nebraska, 69101, United States More Info
Kartik Anand, MD
Contact
308-568-7386
[email protected]
Kartik Anand, MD
Principal Investigator
John Theurer Cancer Center at Hackensack UMC
Hackensack New Jersey, 07601, United States
University of New Mexico
Albuquerque New Mexico, 87131, United States More Info
Ala Ebaid, MD
Contact
505-272-4946
[email protected]
Ala Ebaid, MD
Principal Investigator
Weill Cornell Medical College
New York New York, 10021, United States More Info
Sangmin Lee, MD
Contact
646-962-7200
[email protected]
Sangmin Lee, MD
Principal Investigator
(USO) Oncology Hematology Care
Cincinnati Ohio, 45236, United States More Info
Kruti Patel, DO
Contact
[email protected]
Kruti Patel, DO
Principal Investigator
Ohio State University, The James Cancer Hospital and Solove Research Institute
Columbus Ohio, 43210, United States More Info
Kristen Koenig, MD
Contact
[email protected]
Kristen Koenig, MD
Principal Investigator
University of Pennsylvania Abramson Cancer Center Clinical Research Unit
Philadelphia Pennsylvania, 19104, United States
Baptist Cancer Center
Memphis Tennessee, 38120, United States More Info
Muhammad Raza, MD
Contact
901-226-5151
[email protected]
Muhammad Raza, MD
Principal Investigator
Vanderbilt University Medical Center
Nashville Tennessee, 37232, United States More Info
Sanjay Mohan, MD
Contact
[email protected]
Sanjay Mohan, MD
Principal Investigator
(USO) Texas Oncology Austin - Midtown
Austin Texas, 78705, United States More Info
Jason Melear, MD
Contact
[email protected]
Jason Melear, MD
Principal Investigator
(USO) Texas Oncology (Dallas)
Dallas Texas, 75246, United States More Info
Edward Pearson, MD
Contact
817-939-3733
[email protected]
Edward Pearson, MD
Principal Investigator
MD Anderson Cancer Center
Houston Texas, 77030, United States More Info
Guillermo Garcia-Manero, MD
Contact
[email protected]
Guillermo Garcia-Manero, MD
Principal Investigator
(USO) Texas Oncology (Tyler)
Tyler Texas, 75702, United States More Info
Habte Yimer, MD
Contact
903-579-9800
[email protected]
Habte Yimer, MD
Principal Investigator
Huntsman Cancer Institute
Salt Lake City Utah, 84112, United States More Info
Afaf Osman
Contact
[email protected]
Afaf Osman
Principal Investigator
University of Virginia
Charlottesville Virginia, 22903, United States More Info
Indumathy Varadarajan, MD
Contact
434-305-6983
[email protected]
Indumathy Varadarajan, MD
Principal Investigator
(USO) Virginia Cancer Specialists
Fairfax Virginia, 22031, United States More Info
Mitul Gandhi, MD
Contact
703-280-5390
[email protected]
Mitul Gandhi, MD
Principal Investigator
University of Washington
Seattle Washington, 98109, United States More Info
Anna Halpern, MD
Contact
[email protected]
Anna Halpern, MD
Principal Investigator
(USO) Compass oncology
Vancouver Washington, 98684, United States More Info
Anthony Van Ho, MD
Contact
[email protected]
Anthony Van Ho, MD
Principal Investigator
McMaster - Juravinski Cancer Centre
Hamilton Ontario, , Canada More Info
Dina Khalaf, MD
Contact
[email protected]
Dina Khalaf, MD
Principal Investigator
Princess Margaret Cancer Center
Toronto Ontario, M5G 2, Canada More Info
Karen Yee, MD
Contact
416 946 4495
[email protected]
Karen Yee, MD
Principal Investigator
Princess Margaret Cancer Research
Toronto Ontario, , Canada
MUHC GLEN Site Cedars - Cancer Centre
Montréal Quebec, , Canada
China, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan Hubei, 43002, China
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
Tianjin Tianjin, 30004, China
CHU Nantes
Nantes , 44000, France More Info
Alice Garnier, MD
Contact
33232282589
[email protected]
Alice Garnier, MD
Principal Investigator
Hôpital Cochin APHP
Paris , 75014, France More Info
Lise Willems, MD
Contact
+331.58.41.26.70
[email protected]
Lise Willems, MD
Principal Investigator
Hôpital Necker
Paris , 75015, France More Info
Cecile Bally
Contact
01 44 49 53 42
[email protected]
Cecile Bally
Principal Investigator
Hôpital St Louis
Paris , , France More Info
Pierre Fenaux, MD
Contact
608067570
[email protected]
Pierre Fenaux, MD
Principal Investigator
CHU de Bordeaux
Pessac , 33604, France More Info
Sophie Dimicoli-Salazar, MD
Contact
+33 (0)5 57 65 65 11
[email protected]
Sophie Dimicoli-Salazar, MD
Principal Investigator
CHU de Tours
Tours , 37044, France More Info
Emmanuel Gyan, MD
Contact
33247473712
[email protected]
Emmanuel Gyan, MD
Principal Investigator
CHRU de Nancy
Vandoeuvre-Lès-Nancy , 54500, France More Info
Maud D'Aveni, MD
Contact
33609481716
[email protected]
Maud D'Aveni, MD
Principal Investigator
Clínica Universidad de Navarra
Barcelona , 08036, Spain More Info
Ana Alfonso Pierola
Contact
34627931812
[email protected]
Ana Alfonso Pierola
Principal Investigator
Hospital San Pedro de Alcántara
Cáceres , , Spain More Info
Juan Miguel Bergua, MD
Contact
34927621540
[email protected]
Juan Miguel Bergua, MD
Principal Investigator
Clinical Universidad de Navarra (Madrid site)
Madrid , 28027, Spain More Info
Covadonga Vidal Garcia
Contact
[email protected]
Carlos Grande
Principal Investigator
Hospital 12 de Octubre
Madrid , , Spain More Info
Teresa Cedena, MD
Contact
34609908296
[email protected]
Teresa Cedena, MD
Principal Investigator
Hospital Universitario Central Asturias
Oviedo , , Spain More Info
EVA PEREZ GARCIA
Contact
[email protected]
TERESA BERNAL DEL CASTILLO
Principal Investigator
Hospital Clínic of Barcelona
Pamplona , 31008, Spain More Info
Marina Diaz Beya
Contact
+34 618549072
[email protected]
Marina Diaz Beya
Principal Investigator
Hospital La Fe
Valencia , , Spain More Info
Pau Montesinos, MD
Contact
[email protected]
Pau Montesinos, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Prostate Cancer

Phase:

Phase 1

Estimated Enrollment:

277

Study ID:

NCT02649790

Recruitment Status:

Recruiting

Sponsor:


Karyopharm Therapeutics Inc

How clear is this clinincal trial information?

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