Psoriasis Clinical Trial

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A Phase 2b Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP)

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Summary

A 12-week Randomized, Double-blind, Placebo-controlled, Dose Ranging Phase 2 Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis followed by an Open-label Extension Phase.

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Eligibility Criteria

Inclusion Criteria:

At least 6 months history of moderate or severe PPP, as defined by PPPASI ≥12 and PPPGA ≥3 at screening
Males and females must be willing to use birth control as indicated

Exclusion Criteria:

Moderate to severe psoriasis covering ≥10% of total body surface area (BSA) at screening
Breastfeeding or pregnant
Known immunodeficiency or subject is immunocompromised
Active/latent infection with HBV, HCV, HIV, SARS-CoV-2 or TB
Any topical medications for PPP excluding emollients within two weeks of randomization and systemic therapies (including phototherapy) within 4 weeks of randomization

Study is for people with:

Psoriasis

Phase:

Phase 2

Estimated Enrollment:

79

Study ID:

NCT05194839

Recruitment Status:

Terminated

Sponsor:

Aristea Therapeutics, Inc.

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There are 51 Locations for this study

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Total Skin & Beauty Dermatology Center, PC
Birmingham Alabama, 35205, United States
Dermatology Trial Associates
Bryant Arkansas, 72022, United States
Cosmetic Laser Dermatology
San Diego California, 92121, United States
Clinical Science Institute
Santa Monica California, 90404, United States
Driven Research LLC
Coral Gables Florida, 33134, United States
Encore Medical Research, LLC
Hollywood Florida, 33021, United States
Tory Sullivan, MD PA
North Miami Beach Florida, 33162, United States
Advanced Medical Research PC
Sandy Springs Georgia, 30328, United States
Dawes Fretzin Clinical Research Group, LLC
Indianapolis Indiana, 46250, United States
DS Research
Louisville Kentucky, 40241, United States
Great Lakes Research Group, Inc.
Bay City Michigan, 48706, United States
Washington University School of Medicine-Dermatology
Saint Louis Missouri, 63108, United States
Skin Specialists, PC (Schlessinger MD)
Omaha Nebraska, 68144, United States
ALLCUTIS Research, LLC.
Portsmouth New Hampshire, 03801, United States
Aventiv Research Inc.
Dublin Ohio, 43016, United States
Apex Clinical Research Center
Mayfield Heights Ohio, 44124, United States
Central Sooner Research
Norman Oklahoma, 73071, United States
UPMC Department of Dermatology
Pittsburgh Pennsylvania, 15212, United States
Dermatology Clinical Research Center of San Antonio
San Antonio Texas, 78229, United States
Alberta DermaSurgery Centre
Edmonton Alberta, T6G 1, Canada
Vida Dermatology
Edmonton Alberta, T6H 4, Canada
Central Alberta Research Clinic (CARe Clinic)
Red Deer Alberta, T4P 1, Canada
SimcoDerm Medical and Surgical
Barrie Ontario, L4M 7, Canada
Lynderm Research Inc.
Markham Ontario, L3P 1, Canada
Centre De Recherche Dermatologique Du Quebec Metropolitan Inc.
Québec , G1V 4, Canada
Kožní ambulance Kutná Hora, s.r.o.
Kutná Hora , 284 0, Czechia
Clintrial s.r.o
Prague , 100 0, Czechia
Praglandia s.r.o.
Prague , 150 0, Czechia
Universitätsklinikum Augsburg Klinik für Dermatologie und Allergologie
Augsburg , 86156, Germany
Fachklinik Bad Bentheim Fachbereich Dermatologie und Allergologie
Bad Bentheim , 48455, Germany
Uniklinikum Dresden Klinik und Poliklinik für Dermatologie
Dresden , 01307, Germany
Universitätsklinikum Erlangen Hautklinik
Erlangen , 91054, Germany
TFS Trial Form Support GmbH SCIderm - Zentrum für klinische Studien
Hamburg , 20537, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel [Zentrum für entzundliche Hauterkrankungen] Klinik für Dermatologie, Venerologie und Allergologie
Kiel , 24105, Germany
Hautarztpraxis Mahlow
Mahlow , 15831, Germany
Klinikum der Universität München Klinik und Poliklinik der Dermatologie und Allergologie Der Universität München
München , 80337, Germany
Universitaetsklinikum Muenster
Münster , 48149, Germany
KliFOs - Klinische Forschung Osnabrück
Osnabrück , 49074, Germany
Hautarztpraxis Dres. Leitz & Kollegen
Stuttgart , 70178, Germany
Semmelweis University, Department of Dermatology, Venerology and Dermatooncology
Budapest , 1085, Hungary
University of Debrecen, Dermatology Department
Debrecen , 4012, Hungary
Bács-Kiskun Megyei KórházSzegedi Tudományegyetem Általános Orvostudományi Kar Oktató Kórháza Bórgyógyászati Szakrendelés
Kecskemét , 6000, Hungary
University of Pecs, Department of Dermatology, Venerology and Oncodermatology
Pécs , 7632, Hungary
Diamond Clinic Spolka z ograniczona odpowiedzialnoscia
Kraków , 31-55, Poland
Clinical Best Solutions
Lublin , 20-07, Poland
Luxderm Specjalistyczny Gabinet Dermatologiczny
Lublin , 20-57, Poland
Luxderm Specjalistyczny Gabinet Dermatologiczny
Warsaw , 01-14, Poland
Royalderm Agnieszka Nawrocka
Warsaw , 02-96, Poland
Przychodnia Lekarsko-Psychologinczna Matusiak Spółka Partnerska
Wrocław , 50-56, Poland
DermMedica Sp. z o.o.
Wrocław , 51-31, Poland
Salford Care Organisation
Salford , M6 8H, United Kingdom
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How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 2

Estimated Enrollment:

79

Study ID:

NCT05194839

Recruitment Status:

Terminated

Sponsor:


Aristea Therapeutics, Inc.

How clear is this clinincal trial information?

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