Psoriasis Clinical Trial
A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 52 Weeks of Treatment
Summary
The main aim of this study is to show how well TAK-279 reduces the skin plaques compared to placebo, in participants with moderate-to-severe plaque psoriasis. Participants will be assigned to one of the 3 study treatments (TAK-279, apremilast (an approved treatment), or a placebo). Participants will be in the study for up to 56 weeks.
Full Description
The drug being tested in this study is called TAK-279. TAK-279 is being tested to treat people with moderate to severe plaque psoriasis.
The study will enroll approximately 600 patients. Participants will be randomly assigned (by chance, like flipping a coin) to one of the following treatment groups in a ratio of 3:1:1 to receive TAK-279, placebo, or apremilast which will remain undisclosed to the participant and study doctor during the study (unless there is an urgent medical need):
TAK-279
Placebo
Apremilast
This multi-center trial will be conducted worldwide. Participants will go through a screening process to make sure they meet the rules for taking part in the study. This will take up to 35 days. If participants meet the study rules, they will be treated for up to 52 weeks (1 year). There will be a safety follow-up visit 4 weeks after their last day of treatment.
Eligibility Criteria
Inclusion Criteria:
Plaque psoriasis for at least 6 months.
Moderate to severe disease.
Candidate for phototherapy or systemic therapy.
Exclusion Criteria:
Other forms of psoriasis.
History of recent infection.
Prior exposure to TAK-279 or active comparator.
Other protocol defined inclusion/exclusion criteria apply.
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There are 35 Locations for this study
Phoenix Arizona, 85008, United States More Info
Principal Investigator
Fountain Valley California, 92708, United States More Info
Principal Investigator
Fremont California, 94538, United States More Info
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Coral Gables Florida, 33134, United States More Info
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Fort Lauderdale Florida, 33308, United States More Info
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Hialeah Florida, 33012, United States More Info
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Miami Florida, 33175, United States More Info
Principal Investigator
Ocala Florida, 34470, United States More Info
Principal Investigator
Marietta Georgia, 30060, United States More Info
Principal Investigator
Savannah Georgia, 31419, United States More Info
Principal Investigator
Idaho Falls Idaho, 83404, United States More Info
Principal Investigator
Rolling Meadows Illinois, 60008, United States More Info
Principal Investigator
Indianapolis Indiana, 46256, United States More Info
Principal Investigator
Columbia Maryland, 21046, United States More Info
Principal Investigator
Troy Michigan, 48084, United States More Info
Principal Investigator
Warren Michigan, 48088, United States More Info
Principal Investigator
Henderson Nevada, 89052, United States More Info
Principal Investigator
Portsmouth New Hampshire, 03801, United States More Info
Principal Investigator
New York New York, 10003, United States More Info
Principal Investigator
Cary North Carolina, 27518, United States More Info
Principal Investigator
Bexley Ohio, 43209, United States More Info
Principal Investigator
Charleston South Carolina, 29407, United States More Info
Principal Investigator
Murfreesboro Tennessee, 37130, United States More Info
Principal Investigator
Bellaire Texas, 77401, United States More Info
Principal Investigator
San Antonio Texas, 78213, United States More Info
Principal Investigator
Surrey British Columbia, V3R 6, Canada More Info
Principal Investigator
Ajax Ontario, L1S 7, Canada More Info
Principal Investigator
Barrie Ontario, L4M 7, Canada More Info
Principal Investigator
Etobicoke Ontario, M8X 1, Canada More Info
Principal Investigator
Guelph Ontario, N1H 1, Canada More Info
Principal Investigator
London Ontario, N5X 2, Canada More Info
Principal Investigator
North Bay Ontario, P1B 3, Canada More Info
Principal Investigator
North York Ontario, M2M 4, Canada More Info
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Toronto Ontario, M4W 2, Canada More Info
Principal Investigator
Warszawa Mazowieckie, 02-00, Poland More Info
Principal Investigator
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