Psoriasis Clinical Trial

A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period

Summary

The main aim of this study is to show how well TAK-279 reduces the skin plaques compared to placebo, in participants with moderate-to-severe plaque psoriasis. Participants will be assigned to one of the 3 study treatments (TAK-279, apremilast (an approved treatment), or a placebo). Participants will be in the study for up to 69 weeks.

View Full Description

Full Description

The drug being tested in this study is called TAK-279. TAK-279 is being tested to treat people with moderate to severe plaque psoriasis.

The study will enroll approximately 1000 patients. Participants will be randomly assigned (by chance, like flipping a coin) to one of the three treatment groups for TAK-279, placebo, or apremilast in a ratio of 2:1:1 which will remain undisclosed to the patient and investigator during the study (unless there is an urgent medical need):

TAK-279
Apremilast
Placebo

This multi-center trial will be conducted worldwide. The overall time to participate in this study is 69 weeks. Participants will go through a screening process to make sure they meet the rules for taking part in the study. This will take up to 35 days. If participants meet the study rules, they will be treated for up to 60 weeks. There will be a safety follow-up visit 4 weeks after their last day of treatment.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Plaque psoriasis for at least 6 months.
Moderate to severe disease.
Candidate for phototherapy or systemic therapy.

Exclusion Criteria:

Other forms of psoriasis.
History of recent infection.
Prior exposure to TAK-279 or active comparator.

Other protocol defined inclusion/exclusion criteria apply.

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

1000

Study ID:

NCT06108544

Recruitment Status:

Recruiting

Sponsor:

Takeda

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There are 55 Locations for this study

See Locations Near You

Total Skin and Beauty Dermatology Center
Birmingham Alabama, 35205, United States More Info
Site Contact
Contact
205-933-0987
[email protected]
James Krell, MD
Principal Investigator
Cahaba Dermatology Skin Health Center
Hoover Alabama, 35244, United States More Info
Site Contact
Contact
205-214-7546
[email protected]
Vlada Groysman, DO, MD
Principal Investigator
Medical Dermatology Specialists
Phoenix Arizona, 85006, United States More Info
Site Contact
Contact
602-354-5770
[email protected]
Lindsay Ackerman, MD
Principal Investigator
Noble Clinical Research
Tucson Arizona, 85704, United States More Info
Site Contact
Contact
520-612-7860
[email protected]
Dena Petersen, MD
Principal Investigator
Johnson Dermatology Clinic
Fort Smith Arkansas, 72916, United States More Info
Site Contact
Contact
479-649-3376
[email protected]
Sandra Johnson, MD
Principal Investigator
Burke Pharmaceutical Research
Hot Springs Arkansas, 71913, United States More Info
Site Contact
Contact
501-620-4449
[email protected]
Dowling Stough, MD
Principal Investigator
Zenith Research, Inc.
Beverly Hills California, 90211, United States More Info
Site Contact
Contact
213-949-6427
[email protected]
David Stoll, MD
Principal Investigator
UNISON Clinical Trials (Shahram Jacobs md inc.)
Encino California, 91436, United States More Info
Site Contact
Contact
818-981-1555
[email protected]
Shahram Jacobs, MD
Principal Investigator
First OC Dermatology Research Inc.
Fountain Valley California, 92708, United States More Info
Site Contact
Contact
714-531-2966
[email protected]
Vivian Laquer, MD
Principal Investigator
Long Beach Research Institute, LLC
Long Beach California, 90805, United States More Info
Site Contact
Contact
562-471-3773
[email protected]
Ashley Duzik, DO
Principal Investigator
Metropolis Dermatology Downtown LA - Probity - PPDS
Los Angeles California, 90017, United States More Info
Site Contact
Contact
424-393-0005
[email protected]
James Wang, MD
Principal Investigator
Northridge Clinical Trials
Northridge California, 91325, United States More Info
Site Contact
Contact
714-375-5970
[email protected]
Navid Ezra, MD
Principal Investigator
Therapeutics Clinical Research
San Diego California, 92123, United States More Info
Site Contact
Contact
858-571-6800
[email protected]
Neal Bhatia, MD
Principal Investigator
University Clinical Trials
San Diego California, 92123, United States More Info
Site Contact
Contact
858-278-8470
[email protected]
Walter Nahm, MD, PhD
Principal Investigator
Revival Research Corporation - Florida - ClinEdge - PPDS
Doral Florida, 33122, United States More Info
Site Contact
Contact
305-982-8892
[email protected]
Ivette Espinosa-Fernandez, DO
Principal Investigator
San Marcus Research Clinic Inc
Miami Lakes Florida, 33014, United States More Info
Site Contact
Contact
305-424-7420
[email protected]
Idalia Acosta, MD
Principal Investigator
Florida Academic Centers Research
Miami Florida, 33136, United States More Info
Site Contact
Contact
888-888-8888
[email protected]
Francisco Kerdel, MD
Principal Investigator
FXM Research Miramar
Miramar Florida, 33027, United States More Info
Site Contact
Contact
954-430-1097
[email protected]
Francisco Flores, MD
Principal Investigator
Lenus Research & Medical Group
Sweetwater Florida, 33172, United States More Info
Site Contact
Contact
305-672-7058
[email protected]
John Niven, MD
Principal Investigator
Advanced Clinical Research Institute (ACRI) - Florida
Tampa Florida, 33607, United States More Info
Site Contact
Contact
813-879-7546
[email protected]
Francis Caban, MD
Principal Investigator
Olympian Clinical Research - 6331 Memorial Hwy
Tampa Florida, 33615, United States More Info
Site Contact
Contact
727-935-0508
[email protected]
Matthew Zook, MD, PhD
Principal Investigator
Divine Dermatology and Aesthetics, LLC
Atlanta Georgia, 30315, United States More Info
Site Contact
Contact
470-747-7888
[email protected]
Tunisia Cornelius
Principal Investigator
Advanced Medical Research, PC
Atlanta Georgia, 30342, United States More Info
Site Contact
Contact
404-939-9220
[email protected]
Jamie Weisman, MD
Principal Investigator
Skin Care Physicians of Georgia
Macon Georgia, 31217, United States More Info
Site Contact
Contact
478-742-2180
[email protected]
David Cohen, MD
Principal Investigator
NorthShore Medical Group Dermatology - Skokie
Skokie Illinois, 60077, United States More Info
Site Contact
Contact
847-663-6813
[email protected]
Stephanie Mehlis, MD
Principal Investigator
DS Research - 1005 E. Lewis & Clark Pkwy Indiana Location
Clarksville Indiana, 47129, United States More Info
Site Contact
Contact
502-373-2849
[email protected]
Megan Vissing, MD
Principal Investigator
Skin Sciences, PLLC
Louisville Kentucky, 40217, United States More Info
Site Contact
Contact
502-456-2783
[email protected]
Leon Kircik, MD
Principal Investigator
Dermatology Specialists Research - 3810 Springhurst Blvd
Louisville Kentucky, 40241, United States More Info
Site Contact
Contact
502-585-9059
[email protected]
Cindy Owen, MD
Principal Investigator
Dermatology & Advanced Aesthetics
Lake Charles Louisiana, 70605, United States More Info
Site Contact
Contact
337-477-0011
[email protected]
Shondra Smith, MD
Principal Investigator
Lawrence J Green, MD LLC
Rockville Maryland, 20850, United States More Info
Site Contact
Contact
301-610-0663
[email protected]
Lawrence Green, MD
Principal Investigator
Allcutis Research LLC
Beverly Massachusetts, 01915, United States More Info
Site Contact
Contact
978-372-7252
[email protected]
David Greenstein, MD
Principal Investigator
Beacon Clinical Research LLC
Brockton Massachusetts, 02301, United States More Info
Site Contact
Contact
774-462-6610
[email protected]
Victoria Kuohung, MD
Principal Investigator
David Fivenson MD Dermatology PLLC
Ann Arbor Michigan, 48103, United States More Info
Site Contact
Contact
734-222-9630
[email protected]
David Fivenson, MD
Principal Investigator
Oakland Hills Dermatology - 3400 Auburn Rd
Auburn Hills Michigan, 48326, United States More Info
Site Contact
Contact
833-254-6829
[email protected]
Christofer Buatti, DO
Principal Investigator
Minnesota Clinical Study Center
Fridley Minnesota, 55432, United States More Info
Site Contact
Contact
763-571-4200
[email protected]
Steven Kempers, MD
Principal Investigator
Skin Specialists PC
Omaha Nebraska, 68144, United States More Info
Site Contact
Contact
402-334-7546
[email protected]
Joel Schlessinger, MD
Principal Investigator
Vivida Dermatology - Flamingo Rd - Probity - PPDS
Las Vegas Nevada, 89119, United States More Info
Site Contact
Contact
888-888-8888
[email protected]
Victoria Farley, MD
Principal Investigator
ALLCUTIS Research, LLC.
Portsmouth New Hampshire, 03801, United States More Info
Site Contact
Contact
603-319-8863
[email protected]
Abel Jarell, MD
Principal Investigator
Psoriasis Treatment Center of Central New Jersey
East Windsor New Jersey, 08520, United States More Info
Site Contact
Contact
609-443-4500
[email protected]
Jerry Bagel, MD
Principal Investigator
Sadick Research Group
New York New York, 10075, United States More Info
Site Contact
Contact
212-772-7242
[email protected]
Neil Sadick, MD
Principal Investigator
The Skin Surgery Center for Clinical Research - Objective Health - PPDS
Winston-Salem North Carolina, 27103, United States More Info
Site Contact
Contact
336-200-8208
[email protected]
Kevin Stein, MD
Principal Investigator
ClinOhio Research Services
Columbus Ohio, 43213, United States More Info
Site Contact
Contact
888-888-8888
[email protected]
Benjamin Bogucki, MD
Principal Investigator
Wright State Physicians
Fairborn Ohio, 45324, United States More Info
Site Contact
Contact
937-245-7500
[email protected]
Craig Rohan, MD
Principal Investigator
Apex Clinical Research Center
Mayfield Heights Ohio, 44124, United States More Info
Site Contact
Contact
440-352-7546
[email protected]
Jorge Garcia-Zuazaga, MD
Principal Investigator
Oregon Medical Research Center PC
Portland Oregon, 97239, United States More Info
Site Contact
Contact
503-245-1525
[email protected]
Benjamin Ehst, MD, PhD
Principal Investigator
Tennessee Clinical Research Center
Nashville Tennessee, 37215, United States More Info
Site Contact
Contact
405-271-8707
[email protected]
Michael Gold, MD
Principal Investigator
Arlington Center for Dermatology
Arlington Texas, 76011, United States More Info
Site Contact
Contact
817-795-7546
[email protected]
Angela Moore, MD
Principal Investigator
UT Physicians Dermatology - Bellaire Station
Bellaire Texas, 77401, United States More Info
Site Contact
Contact
713-500-8266
[email protected]
Adelaide Hebert, MD
Principal Investigator
Modern Research Associates
Dallas Texas, 75231, United States More Info
Site Contact
Contact
214-265-1818
[email protected]
Jennifer Cather, MD
Principal Investigator
North Texas Center for Clinical Research
Frisco Texas, 75034, United States More Info
Site Contact
Contact
972-704-2400
[email protected]
Timothy Rodgers, MD
Principal Investigator
Austin Institute for Clinical Research, Inc. - Pflugerville - ClinEdge - PPDS
Pflugerville Texas, 78660, United States More Info
Site Contact
Contact
512-279-2545
[email protected]
Edward Lain, MD
Principal Investigator
Texas Dermatology and Laser Specialists
San Antonio Texas, 78218, United States More Info
Site Contact
Contact
210-852-2779
[email protected]
John Browning, MBA, MD
Principal Investigator
Dermatology Clinical Research Center of San Antonio
San Antonio Texas, 78229, United States More Info
Site Contact
Contact
210-692-1382
[email protected]
Steven Davis, MD
Principal Investigator
Houston Center for Clinical Research, LLC
Sugar Land Texas, 77479, United States More Info
Site Contact
Contact
832-929-6221
[email protected]
Aparna Tamirisa, MD
Principal Investigator
Center For Clinical Studies, LTD. LLP - 451 N Texas Ave
Webster Texas, 77598, United States More Info
Site Contact
Contact
281-333-2288
[email protected]
Patricia Lee, MD
Principal Investigator
Virginia Clinical Research - 6160 Kempsville Cir
Norfolk Virginia, 23507, United States More Info
Site Contact
Contact
757-625-0151
[email protected]
David Pariser, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

1000

Study ID:

NCT06108544

Recruitment Status:

Recruiting

Sponsor:


Takeda

How clear is this clinincal trial information?

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