Psoriasis Clinical Trial
A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period
Summary
The main aim of this study is to show how well TAK-279 reduces the skin plaques compared to placebo, in participants with moderate-to-severe plaque psoriasis. Participants will be assigned to one of the 3 study treatments (TAK-279, apremilast (an approved treatment), or a placebo). Participants will be in the study for up to 69 weeks.
Full Description
The drug being tested in this study is called TAK-279. TAK-279 is being tested to treat people with moderate to severe plaque psoriasis.
The study will enroll approximately 1000 patients. Participants will be randomly assigned (by chance, like flipping a coin) to one of the three treatment groups for TAK-279, placebo, or apremilast in a ratio of 2:1:1 which will remain undisclosed to the patient and investigator during the study (unless there is an urgent medical need):
TAK-279
Apremilast
Placebo
This multi-center trial will be conducted worldwide. The overall time to participate in this study is 69 weeks. Participants will go through a screening process to make sure they meet the rules for taking part in the study. This will take up to 35 days. If participants meet the study rules, they will be treated for up to 60 weeks. There will be a safety follow-up visit 4 weeks after their last day of treatment.
Eligibility Criteria
Inclusion Criteria:
Plaque psoriasis for at least 6 months.
Moderate to severe disease.
Candidate for phototherapy or systemic therapy.
Exclusion Criteria:
Other forms of psoriasis.
History of recent infection.
Prior exposure to TAK-279 or active comparator.
Other protocol defined inclusion/exclusion criteria apply.
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There are 79 Locations for this study
Birmingham Alabama, 35205, United States More Info
Principal Investigator
Hoover Alabama, 35244, United States More Info
Principal Investigator
Phoenix Arizona, 85006, United States More Info
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Tucson Arizona, 85704, United States More Info
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Fort Smith Arkansas, 72916, United States More Info
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Hot Springs Arkansas, 71913, United States More Info
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Beverly Hills California, 90211, United States More Info
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Encino California, 91436, United States More Info
Principal Investigator
Fountain Valley California, 92708, United States More Info
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Long Beach California, 90805, United States More Info
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Los Angeles California, 90017, United States More Info
Principal Investigator
Northridge California, 91325, United States More Info
Principal Investigator
San Diego California, 92123, United States More Info
Principal Investigator
San Diego California, 92123, United States More Info
Principal Investigator
Santa Monica California, 90404, United States More Info
Principal Investigator
Doral Florida, 33122, United States More Info
Principal Investigator
Miami Lakes Florida, 33014, United States More Info
Principal Investigator
Miami Florida, 33136, United States More Info
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Miramar Florida, 33027, United States More Info
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Sweetwater Florida, 33172, United States More Info
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Tampa Florida, 33607, United States More Info
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Tampa Florida, 33615, United States More Info
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Atlanta Georgia, 30315, United States More Info
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Atlanta Georgia, 30342, United States More Info
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Macon Georgia, 31217, United States More Info
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Skokie Illinois, 60077, United States More Info
Principal Investigator
Clarksville Indiana, 47129, United States More Info
Principal Investigator
Louisville Kentucky, 40217, United States More Info
Principal Investigator
Louisville Kentucky, 40241, United States More Info
Principal Investigator
Lake Charles Louisiana, 70605, United States More Info
Principal Investigator
Rockville Maryland, 20850, United States More Info
Principal Investigator
Beverly Massachusetts, 01915, United States More Info
Principal Investigator
Brockton Massachusetts, 02301, United States More Info
Principal Investigator
Ann Arbor Michigan, 48103, United States More Info
Principal Investigator
Ann Arbor Michigan, 48109, United States More Info
Principal Investigator
Auburn Hills Michigan, 48326, United States More Info
Principal Investigator
Fridley Minnesota, 55432, United States More Info
Principal Investigator
Omaha Nebraska, 68144, United States More Info
Principal Investigator
Las Vegas Nevada, 89119, United States More Info
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Portsmouth New Hampshire, 03801, United States More Info
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East Windsor New Jersey, 08520, United States More Info
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Bronx New York, 10467, United States More Info
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New York New York, 10029, United States More Info
Principal Investigator
New York New York, 10075, United States More Info
Principal Investigator
Stony Brook New York, 11790, United States More Info
Principal Investigator
Winston-Salem North Carolina, 27103, United States More Info
Principal Investigator
Columbus Ohio, 43213, United States More Info
Principal Investigator
Fairborn Ohio, 45324, United States More Info
Principal Investigator
Mayfield Heights Ohio, 44124, United States More Info
Principal Investigator
Portland Oregon, 97239, United States More Info
Principal Investigator
Pittsburgh Pennsylvania, 15213, United States More Info
Principal Investigator
Hermitage Tennessee, 37076, United States More Info
Principal Investigator
Nashville Tennessee, 37215, United States More Info
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Arlington Texas, 76011, United States More Info
Principal Investigator
Bellaire Texas, 77401, United States More Info
Principal Investigator
Dallas Texas, 75231, United States More Info
Principal Investigator
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