A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases

Inclusion Criteria:

Male or female aged 18 to 75 years
Have clinical diagnosis of chronic idiopathic urticaria (CIU), chronic idiopathic pruritus (CIP), lichen planus (LP), lichen simplex chronicus (LSC) and plaque psoriasis (PPs) for at least 6 months
Moderate to severe pruritus
Female participants of childbearing potential must have a negative pregnancy test, be nonlactating, and have agreed to use a highly effective method of contraception, as specified in the protocol, from the Screening Visit until 10 weeks after final study drug administration
Able to comprehend and willing to sign an Informed Consent Form and able to abide by the study restrictions and comply with all study procedures for the duration of the study

Exclusion Criteria:

Use of prohibited medications within the indicated timeframe from Day 1 to the End of Study
Is currently using medication known to cause pruritus
Has any inflammatory, pruritic, and/or fibrotic skin condition other than the diagnosis that defines inclusion
Laboratory abnormalities that fall outside the windows specified in the protocol at the Screening Visit
Has an active infection, including skin infection
Any medical or psychiatric condition which, in the opinion of the Investigator or the Sponsor, may place the participant at increased risk as a result of study participation, interfere with study participation or study assessments, affect compliance with study requirements, or complicate interpretation of study results