Cardiovascular Effects in Psoriasis Patients Treated With Adalimumab.

Inclusion Criteria:

Must understand and voluntarily sign an informed consent form.
Must be male or female and age 18-55 years at time of consent.
Must be able to adhere to the study visit schedule and other protocol requirements
Have chronic plaque psoriasis for more than 6 months with a PASI score of 12 or greater at Baseline.
Females of childbearing potential (FCBP)‡ must have a negative urine pregnancy test at screening (Visit 1).
Negative PPD at Screening or 3 months earlier.
Have not used any biologic treatment for psoriasis in the past 12 months.

Exclusion Criteria:

Inability to provide voluntary consent
Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study
Pregnant, trying to become pregnant or breastfeeding
Prior diagnosis of coronary artery disease (CAD) or heart disease.
Systemic fungal infection
History of past or active mycobacterial infection with any species (including Mycobacterium tuberculosis). Latent Mycobacterium tuberculosis infection as indicated by a positive (more than 15mm induration)Purified Protein Derivative [PPD] skin test. Subjects with a positive PPD skin test and documented completion of treatment for latent TB are eligible. Subjects with a positive PPD skin test and not treated or no documentation of completion of treatment are ineligible.
History of recurrent bacterial infection (at least 3 major infections resulting in hospitalization and/or requiring intravenous antibiotic treatment within the past 2 years)
Clinically significant abnormality on the chest x-ray (CXR) at screening. Chest x-rays performed within 3 months prior to start of study drug are acceptable.
Use of any investigational medication within 4 weeks prior to start of study drug or 5 pharmacokinetic/pharmacodynamic half-lives (whichever is longer)
History of Human Immunodeficiency Virus (HIV) infection or Hepatitis C
Positive Hepatitis B Surface antigen at screening
Malignancy or history of malignancy (except for treated [ie, cured] basal-cell skin carcinomas > 3 years prior to screening)
History of any demyelinating disorder such as multiple sclerosis.