Multiple Ascending-Dose Study of XmAb®27564 in Patients With Psoriasis or Atopic Dermatitis

Inclusion Criteria:

The main inclusion and exclusion criteria include, but are not limited to, the following:

Have active mild-to-severe plaque psoriasis or moderate-to-severe atopic dermatitis according to study-specific criteria
Weight between 40 to 150 kg, inclusive
No topical treatments for psoriasis or atopic dermatitis for 2 weeks before randomization
No phototherapy for psoriasis for 4 weeks before randomization
Washout of oral treatments for psoriasis or atopic dermatitis for 4 weeks before randomization
Washout of biologic treatments for psoriasis or atopic dermatitis for 12 weeks before randomization
Stated willingness to comply with all study procedures (including skin biopsies) and availability for the duration of the study

Exclusion Criteria:

Patients with a history of active asthma within 5 years of screening, except those that have well controlled asthma symptoms at screening visit.
Patients who have had any prior investigational treatment with IL-2 therapies