Psoriasis Clinical Trial

Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis

Summary

These studies are designed to assess the synergistic efficacy of topical 0.1% triamcinolone cream paired with 40,000 IU of oral vitamin D3 daily in treating mild to moderate psoriasis. The study is designed to have all subjects treated with triamcinolone cream (TAC) for 4 weeks, then will be randomized 1:1 into vitamin D3 or placebo for an additional 12 weeks. At that time, the study will become open-label and all subjects will be placed on (or continue) vitamin D3 for an additional 12 weeks. The study will take place over 28 weeks total.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Age 18 and older
Mild to severe plaque psoriasis (2% or greater Body Surface Area; Psoriasis Area and Severity Score of 2 or greater; Investigator Grade Assessment of mild-severe)

Exclusion Criteria:

Currently taking medication that alters the normal ion balance of low-dose in blood.
No calcium supplements 1 month prior to baseline (not including multivitamins).
Unstable or uncontrolled illness, including but not limited to cerebro-cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, neurologic or psychiatric disease at screening.
Abnormal laboratory values at screening, that in the opinion of the investigator, would potentially affect patient safety or data integrity.
Not on systemic non-biologic therapy (including, but not limited to, oral psoralen plus ultraviolet A [photochemotherapy (PUVA)] light therapy; cyclosporine; corticosteroids; methotrexate; oral retinoids; apremilast; tofacitinib; mycophenolate mofetil; thioguanine; hydroxyurea; sirolimus; tacrolimus; azathioprine; leflunomide; fumaric acid derivatives; or 1, 25 dihydroxy vitamin D3 and analogues) within 28 days prior to baseline.
No phototherapy (including either oral and topical PUVA light therapy, ultraviolet B, excimer laser, or self-treatment with tanning beds or therapeutic sunbathing) within 28 days prior to baseline.
No topical treatment (including, but not limited to, corticosteroids [upper mid strength or lower potency topical steroids are permitted on the intertriginous areas and face], crisaborole, anthralin, calcipotriene, topical vitamin D derivatives, retinoids, tazarotene, pimecrolimus, tacrolimus, emollients and other nonprescription topical products containing urea, >3% salicylic acid, alpha- or beta-hydroxyl acids, or medicated shampoos [for example those that contain >3% salicylic acid, corticosteroids, coal tar, or vitamin D3 analogues]) within 14 days prior to baseline.
No biologic agents within 8 weeks or three half-lives, whichever is greater prior to baseline.
History of renal impairment.
History of renal stones.
History of parathyroid abnormalities
Osteoporosis
History of severe arthritis
Ongoing use of tanning bed or other UV device or excessive sunlight
Unable to understand/complete informed consent.

Study is for people with:

Psoriasis

Phase:

Early Phase 1

Estimated Enrollment:

24

Study ID:

NCT04036188

Recruitment Status:

Recruiting

Sponsor:

Wright State University

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There is 1 Location for this study

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Wright State Physicians
Fairborn Ohio, 45324, United States

How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Early Phase 1

Estimated Enrollment:

24

Study ID:

NCT04036188

Recruitment Status:

Recruiting

Sponsor:


Wright State University

How clear is this clinincal trial information?

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