Tumor Treating Fields for Glioblastoma
- Tumor Treating Fields (TTFs) represent a groundbreaking advancement in the management of glioblastoma, an aggressive form of brain cancer.
- TTFs are delivered by a device known as Optune, which harnesses advanced technology to target glioblastoma cells while preserving healthy tissue.
- This therapy involves placing adhesive electrode arrays on the scalp, which deliver low-intensity, alternating electric fields that disrupt tumor growth.
- It’s been shown to slow cancer progression by several months, but some patients opt not to undergo the therapy as it requires wearing the Optune device daily for most of the day.
TTFs, which are delivered by a device known as Optune, harness advanced technology to specifically target glioblastoma cells while preserving healthy tissue. This therapy involves placing adhesive electrode arrays on the scalp, which deliver low-intensity, alternating electric fields at a specific frequency. These fields interfere with cancer cell division, disrupting tumor growth and potentially slowing its progression.
Read MoreHow Do Tumor Treating Fields Work?
TTFs work by delivering low-intensity, alternating electric fields to the tumor site. These fields interfere with cancer cell division, preventing the tumor from growing and spreading. The device consists of adhesive electrode arrays placed on the patient’s scalp, which continuously send electric signals through the skin and into the brain tissue. These signals specifically target rapidly dividing cancer cells while sparing normal brain cells, which do not divide as frequently.The therapy is portable and battery-operated, allowing patients to continue their daily activities while receiving treatment. Unlike traditional chemotherapy or radiation, TTFs do not involve medication or invasive procedures, making it a unique and non-toxic treatment option.
Who is a Candidate for TTF Therapy?
TTF therapy is approved by the Food and Drug Administration (FDA) for adult patients with newly diagnosed and recurrent glioblastoma.
It is typically recommended for:
- Patients who completed initial resection or biopsy, and chemotherapy combined with radiation as part of the standard of care for GBM
- Those who are receiving maintenance chemotherapy (such as temozolomide) and can benefit from additional treatment
- Patients who are able to commit to wearing the device for the recommended duration
It is essential to consult with a neuro-oncologist, radiation oncologist, or medical oncologist to determine if TTF therapy is the right option for you. Factors such as overall health, tumor location, and personal preferences play a role in deciding whether to incorporate TTFs into a treatment plan.
“Some patients choose to do it; others kind of look at the inconvenience and choose not to — so that’s really a patient-specific decision, but is it an option as part of standard therapy,” Dr. Colman explains.
What Are The Side Effects?
One of the most significant advantages of TTF therapy is that it has fewer systemic side effects compared to chemotherapy and radiation.
However, patients may experience:
- Skin irritation: The most common side effect is mild to moderate skin irritation where the electrode arrays are placed. This can include redness, itching, or rash. Keeping the scalp clean and following skincare recommendations can help minimize discomfort.
- Mild headaches: Some patients report mild headaches, which can often be managed with over-the-counter pain relievers.
- Fatigue: Similar to other cancer treatments, some patients experience fatigue, although it is usually not severe.
- Discomfort from wearing the device: Adjusting to wearing the arrays and carrying the device can take time, but most patients find it manageable with practice and support.
Unlike chemotherapy, TTFs do not cause nausea, immune suppression, or hair loss, making them a well-tolerated option for many patients.
How Often Do I Need to Wear the Device?
For the best results, patients are encouraged to wear the TTF device for at least 18 hours per day. Clinical trials have shown that longer daily usage is associated with improved survival outcomes. While wearing the device continuously may seem challenging, many patients find ways to integrate it into their routine with the help of caregivers and support from their medical team.
Tips for wearing the device:
- Plan breaks strategically, such as during showering or when changing electrode arrays.
- Use head coverings or scarves to feel more comfortable in social settings.
- Keep the battery pack charged and carry extra supplies when traveling.
- Communicate with healthcare providers about any discomfort or concerns to receive personalized adjustments and advice.
If you or a loved one are considering TTF therapy, speak with your doctor to understand how it fits into your treatment plan. With proper use, support, and ongoing research, TTFs continue to pave the way for improved outcomes in glioblastoma care.
Questions to Ask Your Doctor
- Am I a candidate for tumor treating fields?
- How will we monitor if the treatment is working?
- What are the side effects I should look out for?
- What can I do to prepare for the treatment?
Learn more about SurvivorNet's rigorous medical review process.
