Bladder Cancer Clinical Trial
Associations Between Chemotherapy-Induced Nausea in Patients With Genitourinary, Sarcoma or Melanoma Cancers and Changes in Gut Microbiome: Potential for Precision Therapeutics
Summary
The objective of this pilot cohort study is to investigate associations between CIN and changes in gut microbiome composition profiles.
Full Description
The long-term goal of this study is to alleviate the occurrence of CIN and to improve chemotherapy treatment outcomes. The identification of associations between CIN and chemotherapy-induced changes in gut microbiome composition profiles will increase our understanding of these mechanisms that underlie CIN. An increased understanding of the underlying mechanisms will provide targets for the development of novel interventions to help alleviate CIN.
Eligibility Criteria
Inclusion Criteria:
at least 20 years of age
last chemotherapy more than 3 years ago
scheduled to receive either moderate to highly emetogenic chemotherapy with or without targeted therapies including immunotherapies) or immunotherapies/targeted therapies alone that can lead to toxicity symptoms for example, nausea and fatigue.
Patients receiving chemotherapy and/or immunotherapy treatment at a Mayo Clinic infusion center or an infusion center outside of Mayo Clinic
Exclusion Criteria:
concurrent radiation therapy
concurrent antibiotic treatment
concurrent oncolytic virus treatment
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There are 3 Locations for this study
Scottsdale Arizona, 85259, United States More Info
Principal Investigator
Jacksonville Florida, 32224, United States More Info
Principal Investigator
Rochester Minnesota, 55905, United States More Info
Principal Investigator
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