Bladder Cancer Clinical Trial

Study of Atezolizumab as Monotherapy and in Combination With Platinum-Based Chemotherapy in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma

Summary

A Phase III, randomised study of atezolizumab alone and in combination with chemotherapy versus chemotherapy alone in participants with untreated advanced urothelial cancer.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria

Considered to be eligible to receive platinum-based chemotherapy, in the investigator's judgment
Eastern Cooperative Oncology Group (ECOG) performance status of less than or equal to ( Histologically documented, locally advanced (T4b, any N; or any T, N2-3) or metastatic urothelial carcinoma (mUC) (M1, Stage IV) (also termed transitional cell carcinoma [TCC] or urothelial cell carcinoma [UCC] of the urinary tract; including renal pelvis, ureters, urinary bladder, and urethra)
Representative formalin-fixed paraffin-embedded (FFPE) tumor specimens in paraffin blocks (blocks preferred) or at least 15 unstained slides, with an associated pathology report, for central testing and determined to be evaluable for tumor PD-L1 expression prior to study enrollment; participants who have fewer than 15 unstained slides available at baseline (but no less than [<] 10) may be eligible following discussion with the Medical Monitor
No prior chemotherapy for inoperable locally advanced or mUC
For participants who received prior adjuvant/neoadjuvant chemotherapy or chemo-radiation for urothelial carcinoma, a treatment-free interval more than (>) 12 months between the last treatment administration and the date of recurrence is required in order to be considered treatment naive in the metastatic setting
Prior local intravesical chemotherapy or immunotherapy is allowed if completed at least 4 weeks prior to the initiation of study treatment
Measurable disease, as defined by RECIST v1.1
Adequate hematologic and end-organ function
For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods that result in a failure rate of <1% per year during the treatment period and for at least 6 months after the last dose of carboplatin, cisplatin, or gemcitabine or for 5 months after the last dose of atezolizumab
For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures and agreement to refrain from donating sperm

Exclusion Criteria:

Any approved anti-cancer therapy, including chemotherapy or hormonal therapy, within 3 weeks prior to initiation of study treatment
Treatment with any other investigational agent or participation in another clinical study with therapeutic intent within 28 days prior to enrolment
Active or untreated CNS metastases as determined by computed tomography (CT) or magnetic resonance imaging evaluation during screening and prior radiographic assessments
Participants with treated asymptomatic central nervous system (CNS) metastases are eligible, provided they meet all of the following criteria: * Evaluable or measurable disease outside the CNS * No metastases to midbrain, pons, medulla, or within 10 mm of the optic apparatus (optic nerves and chiasm) * No history of intracranial or spinal cord hemorrhage * No ongoing requirement for corticosteroid as therapy for CNS disease; anti-convulsants at a stable dose are allowed * No evidence of significant vasogenic edema * No stereotactic radiation, whole-brain radiation or neurosurgical resection within 4 weeks prior to Cycle 1, Day 1 * Radiographic demonstration of interim stability (i.e., no progression) between the completion of CNS-directed therapy and the screening radiographic study * Screening CNS radiographic study >/=4 weeks since completion of radiotherapy or surgical resection and >/=2 weeks since discontinuation of corticosteroids
Prior treatment with CD137 agonists, anti-CTLA-4, anti-programmed death-1 (PD-1), or anti-PD-L1 therapeutic antibody or pathway-targeting agents
Treatment with systemic corticosteroids or other systemic immunosuppressive medications (including but not limited to prednisone, dexamethasone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [TNF] agents) within 2 weeks prior to Cycle 1, Day 1 or anticipated requirement for systemic immunosuppressive medications during the study
Leptomeningeal disease
Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently)
Uncontrolled tumour-related pain or hypercalcemia
Significant cardiovascular disease including known left ventricular ejection fraction (LVEF) <40%
Severe infections within 4 weeks before randomization or therapeutic oral or IV antibiotics within 2 weeks before randomization
Major surgical procedure within 4 weeks prior to randomization or anticipation of need for a major surgical procedure during the course of the study other than for diagnosis
Malignancies other than urothelial carcinoma within 5 years prior to Cycle 1, Day 1
Life expectancy of <12 weeks
Pregnant or lactating, or intending to become pregnant during the study
Serum albumin <25 gram per liter (gL)
History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
Known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation
History of autoimmune disease
Participants with prior allogeneic stem cell or solid organ transplantation
History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced pneumonitis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia), or evidence of active pneumonitis on screening chest CT scan
Positive test for human immunodeficiency virus (HIV)
Active hepatitis B or hepatitis C
Active tuberculosis
Administration of a live, attenuated vaccine within 4 weeks before Cycle 1, Day 1

Study is for people with:

Bladder Cancer

Phase:

Phase 3

Estimated Enrollment:

1214

Study ID:

NCT02807636

Recruitment Status:

Active, not recruiting

Sponsor:

Hoffmann-La Roche

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There are 215 Locations for this study

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Highlands Oncology Group
Springdale Arkansas, 72762, United States
Coastal Integrative Cancer Care
San Luis Obispo California, 93401, United States
Yale School of Medicine
New Haven Connecticut, 06510, United States
Norwalk Hospital
Norwalk Connecticut, 06856, United States
Christina Care Institutional Review Board
Newark Delaware, 18713, United States
Florida Cancer Specialists; Department of Oncology
Fort Myers Florida, 33901, United States
UF Health Cancer Center at Orlando Health
Orlando Florida, 32824, United States
Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building)
Saint Petersburg Florida, 33705, United States
Moffitt Cancer Center; GME Office
Tampa Florida, 33612, United States
The University of Chicago Biological Sciences; Dept. of Medicine, Section of Hematology/Oncology
Chicago Illinois, 60637, United States
Parkview Research Center
Fort Wayne Indiana, 46845, United States
Norton Cancer Institute
Louisville Kentucky, 40202, United States
East Jefferson Hematology Oncology; Hematology Oncology-Yenni Pavillion
Metairie Louisiana, 70006, United States
Park Nicollet Clin-Cancer Ctr
Saint Louis Park Minnesota, 55426, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89128, United States
Mount Sinai School of Medicine - Tisch Cancer Institute
New York New York, 10029, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
University of North Carolina, Lineberger Cancer Ctr
Chapel Hill North Carolina, 27599, United States
Bon Secours - St. Francis Hospital
Greenville South Carolina, 29607, United States
Sarah Cannon Cancer Center
Germantown Tennessee, 38138, United States
Macquarie University Hospital
Macquarie Park New South Wales, 2109, Australia
Royal Brisbane and Women's Hospital
Herston Queensland, 4029, Australia
Lyell McEwin Hospital
Adelaide South Australia, 5112, Australia
Ashford Cancer Center Research
Kurralta Park South Australia, 5037, Australia
Box Hill Hospital
Box Hill Victoria, 3128, Australia
Cabrini Medical Centre; Oncology
Malvern Victoria, 3144, Australia
Sunshine Hospital; Oncology Research
St Albans Victoria, , Australia
GHdC Site Notre Dame
Charleroi , 6000, Belgium
AZ Sint Lucas (Sint Lucas)
Gent , 9000, Belgium
UZ Leuven Gasthuisberg
Leuven , 3000, Belgium
CHC MontLégia
Liege , 4000, Belgium
University Clinical Centre of the Republic of Srpska
Banja Luka , 78000, Bosnia and Herzegovina
Clinic of Oncology, University Clinical Center Sarajevo
Sarajevo , 7100, Bosnia and Herzegovina
Hospital Luxemburgo; Oncologia
Belo Horizonte MG, 31190, Brazil
CETUS Hospital Dia Oncologia
Uberaba MG, 38082, Brazil
Clinicas Oncologicas Integradas - COI
Rio De Janeiro RJ, 22290, Brazil
Hospital de Caridade de Ijui; Oncologia
Ijui RS, 98700, Brazil
Hospital das Clinicas - UFRGS
Porto Alegre RS, 90035, Brazil
Hospital Sao Lucas - PUCRS
Porto Alegre RS, 90610, Brazil
Hospital Nossa Senhora da Conceicao
Porto Alegre RS, 91350, Brazil
Clinica Viver
Santa Maria RS, 97015, Brazil
Clinica de Neoplasias Litoral
Itajai SC, 88301, Brazil
Hospital de Base de Sao Jose do Rio Preto
Sao Jose do Rio Preto SP, 15090, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo SP, 01246, Brazil
Beneficencia Portuguesa de Sao Paulo
São Paulo SP, 01321, Brazil
Tom Baker Cancer Centre-Calgary; Clinical Research Unit
Calgary Alberta, T2N 4, Canada
Cross Cancer Institute
Edmonton Alberta, T6G 1, Canada
BC Cancer Agency, CSI
Kelowna British Columbia, V1Y 5, Canada
Dr. Georges L. Dumont University Hospital Centre
Moncton New Brunswick, E1C 8, Canada
Juravinski Cancer Clinic; Clinical Trials Department
Hamilton Ontario, L8V 5, Canada
Lakeridge Health Center; R. S. MacLaughlin Durham Regional Cancer Center
Oshawa Ontario, L1G 2, Canada
North York General Hospital
Toronto Ontario, M2J 1, Canada
Bradford Hill Centro de Investigaciones Clinicas; Bradford Hill Centro de Investigaciones Clinicas
Recoleta , 84203, Chile
OrlandiOncología
Santiago , 75007, Chile
Fundacion Arturo Lopez Perez
Santiago , 75009, Chile
Clinica Alemana
Vitacura , 0, Chile
Peking Union Medical College Hospital
Beijing City , 10003, China
Beijing Friendship Hospital
Beijing , 10005, China
Chongqing Cancer Hospital
Chongqing , 40003, China
Sun Yat-sen Memorial Hospital
Guangzhou , 51000, China
Jiangsu Cancer Hospital
Nanjing City , 21110, China
Fudan University Shanghai Cancer Center
Shanghai City , 20012, China
Zhongshan Hospital Fudan University
Shanghai , 20003, China
Huadong Hospital Affiliated to Fudan University
Shanghai , 20004, China
The 2nd Hospital of Tianjin Medical University
Tianjin , 20120, China
Masarykuv onkologicky ustav
Brno , 656 5, Czechia
Fakultni nemocnice Olomouc; Onkologicka klinika
Olomouc , 779 0, Czechia
Vseobecna fakultni nemocnice v Praze
Praha 2 , 128 0, Czechia
University Hospital Motol; Department of Urology
Praha 5 , 15006, Czechia
East Tallinn Central Hospital
Tallinn , 10138, Estonia
North Estonia Medical Centre Foundation; Oncology Center
Tallinn , 13419, Estonia
Oulu University Hospital; Oncology
Oulu , 90029, Finland
Turku Uni Central Hospital; Oncology Clinics
Turku , 20520, Finland
Research institute for Clinical Medicine
Tbilisi , 0112, Georgia
National Center of Urology
Tbilisi , 0144, Georgia
Chemotherapy and Immunotherapy Clinic Medulla
Tbilisi , 0186, Georgia
Alexandras General Hospital of Athens; Oncology Department
Athens , 115 2, Greece
University Hospital of Patras Medical Oncology
Patras , 265 0, Greece
Princess Margaret Hospital; Oncology
Hong Kong , , Hong Kong
Queen Elizabeth Hospital; Clinical Oncology
Hong Kong , , Hong Kong
Queen Mary Hospital; Dept. of Clinical Oncology
Hong Kong , , Hong Kong
The Chinese University of Hong Kong; Department of Clinical Oncology
N.t. , , Hong Kong
Rambam Health Care Campus; Oncology
Haifa , 31096, Israel
Azienda Ospedaliera A. Cardarelli; Dip. Oncopneumoematologico
Napoli Campania, 80131, Italy
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola Emilia-Romagna, 47014, Italy
A.O. Universitaria Policlinico Di Modena; Oncologia
Modena Emilia-Romagna, 41100, Italy
Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche
Roma Lazio, 00161, Italy
Az. Osp. Uni Ria San Martino; Cliniche Uni Rie Convenzionate U.O. Oncologia Medical
Genova Liguria, 16132, Italy
ASST DI CREMONA; Dip. Medicina - S.C. Oncologia
Cremona Lombardia, 26100, Italy
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
Milano Lombardia, 20133, Italy
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia
Rozzano Lombardia, 20089, Italy
A.O CITTA' DELLA SALUTE E DELLA SCIENZA D. - Presidio San Lazzaro; Oncologia medica 2
Torino Piemonte, 10126, Italy
IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
San Giovanni Rotondo Puglia, 71013, Italy
Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia
Arezzo Toscana, 52100, Italy
Azienda Ospedaliera S. Maria - Terni; Oncologia
Terni Umbria, 05100, Italy
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima
Padova Veneto, 35128, Italy
Nagoya University Hospital
Aichi , 466-8, Japan
Hirosaki University Hospital
Aomori , 036-8, Japan
National Hospital Organization Shikoku Cancer Center
Ehime , 791-0, Japan
Gunma University Hospital
Gunma , 371-8, Japan
National Hospital Organization Hokkaido Cancer Center
Hokkaido , 003-0, Japan
University of Tsukuba Hospital
Ibaraki , 305-8, Japan
Kanazawa University Hospital
Ishikawa , 920-8, Japan
Kumamoto University Hospital
Kumamoto , 860-8, Japan
Niigata University Medical & Dental Hospital
Niigata , 951-8, Japan
Osaka Metropolitan University Hospital
Osaka , 545-8, Japan
Kindai University Hospital
Osaka , 589-8, Japan
Toranomon Hospital
Tokyo , 105-8, Japan
The Cancer Institute Hospital, JFCR; Urology
Tokyo , 135-8, Japan
Keio University Hospital
Tokyo , 160-8, Japan
Kyungpook National University Medical Center
Daegu , 41404, Korea, Republic of
Gachon University Gil Medical Center
Incheon , 21565, Korea, Republic of
Korea University Anam Hospital
Seoul , 02841, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of
Severance Hospital, Yonsei University Health System
Seoul , 03722, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Samsung Medical Center
Seoul , 06351, Korea, Republic of
Hospital Kuala Lumpur; Jabatan Radioterapi dan Onkologi
Kuala Lumpur , 50586, Malaysia
University Malaya Medical Centre; Clinical Oncology Unit,
Kuala Lumpur , 59100, Malaysia
Health Pharma Professional Research
Cdmx Mexico CITY (federal District), 03100, Mexico
IMSS Hospital General de Zona No. 48 S. Pedro Xalpa; Departamento de Urología
Ciudad De México DF , 02710, Mexico
Hospital San Jose; Centro de investigacion y transferencia en salud del Tec de Monterrey
Monterrey, N.L , 64710, Mexico
Cancerología
Queretaro , 76090, Mexico
Consultorio Médico
Zapopan, Jalisco , 45040, Mexico
Hagaziekenhuis, locatie Leyweg
Den-Haag , 2545 , Netherlands
Martini Ziekenhuis; Dept of Internal Medicine
Groningen , 9728 , Netherlands
Zuyderland Medisch Centrum; Internal Diseases
Sittard-Geleen , 6162 , Netherlands
Isala Klinieken, Sophia
Zwolle , 8025 , Netherlands
Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej
Bialystok , 15-02, Poland
Przychodnia Lekarska KOMED, Roman Karaszewski
Konin , 62-50, Poland
Szpital Uniwersytecki w Krakowie; Oddzial Kliniczny Onkologii i Poradnia Onkologiczna
Kraków , 31-50, Poland
Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii
Lodz , 93-51, Poland
Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu
Poznan , 60-56, Poland
NU-MED Centrum Diagnostyki i Terapii Onkologicznej
Tomaszów Mazowiecki , 97-20, Poland
Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o.
Warszawa , 04-07, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego; Oddzial Urologii i Onkologii
Wroclaw , 50-55, Poland
Hospital de Santa Maria; Servico de Oncologia Medica
Lisboa , 1649-, Portugal
IPO do Porto; Servico de Oncologia Medica
Porto , 4200-, Portugal
Spitalul Judetean de Urgenta Dr Constantin Opris
Baia Mare , 43003, Romania
Institute Of Oncology Bucharest; Medical Oncology
Bucharest , 02233, Romania
Oncology Center Sf. Nectarie
Craiova , 20034, Romania
ALTAI REGIONAL ONCOLOGICAL CENTER; "Nadezhda" Clinic
Barnaul Altaj, 65604, Russian Federation
SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF
Sankt-peterburg Leningrad, 19702, Russian Federation
Sverdlovsk Regional Clinical Hospital 1
Ekaterinburg , 62010, Russian Federation
Ivanovo Regional Oncology Dispensary
Ivanovo , 15304, Russian Federation
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy
Krasnoyarsk , 66013, Russian Federation
Blokhin Cancer Research Center; Urological Dept
Moscow , 11547, Russian Federation
Russian Scientific Center of Roentgenoradiology
Moscow , 11799, Russian Federation
P.A. Herzen Oncological Inst. ; Oncology
Moscow , 12528, Russian Federation
Privolzhsk Regional Medical Center
Nizhny Novgorod , 60300, Russian Federation
Scientific Research Oncology Institute named after N.N. Petrov; Oncology
St. Petersburg , 19775, Russian Federation
SBEI of HPE "Bashkir State Medical University" of MoH RF
Ufa , 45000, Russian Federation
Clinical Center of Serbia; Clinic of Urology
Belgrade , 11000, Serbia
Clinical Centre Nis, Clinic for Oncology
Nis , 18000, Serbia
Oncology Institute of Vojvodina
Sremska Kamenica , 21204, Serbia
National University Hospital; National University Cancer Institute, Singapore (NCIS)
Singapore , 11922, Singapore
National Cancer Centre; Medical Oncology
Singapore , 16961, Singapore
Oncocare Cancer Centre; Gleneagles Medical Centre
Singapore , , Singapore
Institute of Oncology Ljubljana
Ljubljana , 1000, Slovenia
GVI Oncology Outeniqua Unit; GVI Oncology Outeniqua Unit
George , 6530, South Africa
Cancercare
Port Elizabeth , 6045, South Africa
Wilgers Oncology Centre
Pretoria , 0001, South Africa
Steve Biko Academic Hospital; Oncology
Pretoria , 0002, South Africa
Sandton Oncology Medical Group
Sandton , 2196, South Africa
Hospital General Universitario de Elche; Servicio de Oncologia
Elche Alicante, 03203, Spain
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona Barcelona, 08916, Spain
Institutio Catalan De Oncologia
Badalona Barcelona, 08916, Spain
Complejo Hospitalario de Althaia; Servicio de Oncologia
Manresa Barcelona, 08243, Spain
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
Sabadell Barcelona, 8208, Spain
Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
Santander Cantabria, 39008, Spain
Hospital Provincial de Castellon; Servicio de Oncologia
Castellon de La Plana Castellon, 12002, Spain
Hospital Universitario Reina Sofia; Servicio de Oncologia
Córdoba Cordoba, 14004, Spain
Hospital Universitario Son Espases
Palma De Mallorca Islas Baleares, 07014, Spain
Clinica Universitaria de Navarra; Servicio de Oncologia
Pamplona Navarra, 31008, Spain
Hospital Alvaro Cunqueiro
Vigo Pontevedra, 36312, Spain
Hospital de Basurto; Servicio de Oncologia
Bilbao Vizcaya, 48013, Spain
Complejo Hospitalario Universitario de Albacete; Servicio de Oncologia
Albacete , 02006, Spain
Hospital Univ Vall d'Hebron; Servicio de Oncologia
Barcelona , 08035, Spain
Hospital Clinic de Barcelona. Unidad de Nuevas Terapias;Oncology Department
Barcelona , 08036, Spain
Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
Barcelona , 08041, Spain
Complejo Asistencial Universitario De Burgos; Servicio de Oncologia
Burgos , 09006, Spain
Hospital San Pedro De Alcantara; Servicio de Oncologia
Caceres , 10003, Spain
Hospital Universitario Virgen de las Nieves; Servicio de Oncologia
Granada , 18014, Spain
Hospital Juan Ramon Jimenez;Servicio de Oncologia
Huelva , 21005, Spain
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaen , 23007, Spain
Complejo Asistencial Universitario de Leon; Servicio de Oncologia
Leon , 24071, Spain
Hospital Universitario Lucus Augusti
Lugo , 27003, Spain
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
Madrid , 28007, Spain
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid , 28034, Spain
Hospital Universitario Clínico San Carlos; Servicio de Oncologia
Madrid , 28040, Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia
Madrid , 28041, Spain
Hospital Universitario La Paz; Servicio de Oncologia
Madrid , 28046, Spain
Hospital Universitario Virgen del Rocio; Servicio de Oncologia
Sevilla , 41013, Spain
Hospital Universitario de Toledo
Toledo , 45007, Spain
Hospital Universitario la Fe; Servicio de Oncologia
Valencia , 46026, Spain
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
Zaragoza , 50009, Spain
Hospital Universitario Miguel Servet; Servicio de Oncologia Medica
Zaragoza , 50009, Spain
Chang Gung Medical Foundation - Kaohsiung; Oncology
Kaohisung , 833, Taiwan
China Medical University Hospital; Urology
Taichung , 40447, Taiwan
Taichung Veterans General Hospital; Division of Urology
Taichung , 407, Taiwan
National Cheng Kung Uni Hospital; Dept of Hematology and Oncology
Tainan , 704, Taiwan
National Taiwan Uni Hospital; Dept of Oncology
Taipei , 100, Taiwan
Chang Gung Medical Foundation-Linkou, Urinary Oncology
Taoyuan , 333, Taiwan
Vajira Hospital
Bangkok , 10300, Thailand
Chulalongkorn Hospital; Medical Oncology
Bangkok , 10330, Thailand
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc
Bangkok , 10400, Thailand
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology
Bangkok , 10700, Thailand
Maharaj Nakorn Chiang Mai Hospital; Department of Medicine
ChiangMai , 50200, Thailand
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology
Adana , 01230, Turkey
Ankara City Hospital
Ankara , 06490, Turkey
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Edirne , 22030, Turkey
Bezmi Alem Vakif University Medical School; Oncology
Istanbul , 34093, Turkey
Istanbul University Cerrahpaşa-Cerrahpaşa Medical Faculty; Medikal Onkoloji Departmani
Istanbul , 34098, Turkey
Goztepe Prof.Dr. Suleyman Yalcin City Hospital; Clinical Oncology
Kadiköy , 34722, Turkey
Medikal Park Izmir Hospital
Karşıyaka , 35575, Turkey
19 Mayis University Medical Faculty; Medical Oncology Department
Samsun , 55139, Turkey
Hacettepe Uni Medical Faculty Hospital; Oncology Dept
Sihhiye/Ankara , 06230, Turkey
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval Department of Urology #4
Kharkiv Kharkiv Governorate, 61037, Ukraine
CI Dnipropetrovsk CMCH #4 MA of MOHU Ch of Oncology and MR
Dnipropetrovsk , 49102, Ukraine
Zaporizhzhia Regional Clinic
Zaporizhzhia , 69600, Ukraine
Beatson West of Scotland Cancer Centre
Glasgow , G12 0, United Kingdom
University College London Hospitals NHS Foundation Trust - University College Hospital
London , NW1 2, United Kingdom
The Christie NHS Foundation Trust
Manchester , M20 4, United Kingdom
The York Hospital
York , YO31 , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Bladder Cancer

Phase:

Phase 3

Estimated Enrollment:

1214

Study ID:

NCT02807636

Recruitment Status:

Active, not recruiting

Sponsor:


Hoffmann-La Roche

How clear is this clinincal trial information?

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