This study will collect biospecimens (including blood, tissue, and stool samples) and health information to create a database-a type of collection of information-for better understanding young onset colorectal cancer (YOCRC). The study will include both people with YOCRC and healthy people.
18-49 years old Histological or cytological diagnosis of colorectal adenocarcinoma Planned CRC resection biopsy, or colonoscopy ,including surveillance colonoscopies and/or have already undergone prior surgical resection, with tissue, including normal colonic mucosae distant from the malignant tumor (only patients providing tissue sample) Enrollment in IRB# 20-315, Young Onset Gastrointestinal Cancer Prospective Registry (Andrea Cercek, PI)
Healthy Control Cohort:
18-49 years old Scheduled for standard-of-care colonoscopy at MSK
Exclusion Criteria:
CRC Cohort: Antibiotic use within 6 months of collection of stool for gut microbiome analysis s (only patients providing stool sample) Known inherited cancer susceptibility gene History of inflammatory bowel disease
Healthy Control Cohort:
Antibiotic use within 6 months of collection of stool for gut microbiome analysis (only patients providing stool sample) History of or prior treatment for cancer ≤ 5 years prior to registration. Exceptions include non-melanoma skin cancer, ductal carcinoma in situ, bladder carcinoma in situ, or carcinoma-in-situ of the cervix. Colonoscopy for indications of IBD, anemia and/or genetic predisposition (only patients providing tissue sample).
