Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

Inclusion Criteria:

Age ≥18 years
Histologically confirmed stage II or III colon cancer
Completed surgical resection with curative intent
Plan to initiate an oxaliplatin-based chemotherapy regimen
Engage in <60 minutes per week of moderate- to vigorous-intensity structured aerobic exercise
No planned major surgery during the study period
Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
Can walk 400 meters
Can read and speak English
Ability to provide written informed consent
Provide written approval by qualified healthcare professional
Willing to be randomized

Exclusion Criteria:

Evidence of metastatic colon cancer
Concurrently actively treated other (non-colon) cancer
Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
Currently participating in another study with competing outcomes
Any other condition that, in the opinion of the investigator, would preclude participation or successful compliance with the protocol
Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol