Colon Cancer Clinical Trial
COLON-MD: Colon Cancer Longitudinal Study
Summary
The goal of this proposal is to identify how the composition of the gut microbiome and diet interact to impact chemotherapy-induced diarrhea incidence and severity.
Full Description
In this longitudinal observational study patients will supply samples of their gut microbiome prior to scheduled colonoscopy or surgery along with dietary intake and blood samples; the relative abundance of microbes from those samples along with dietary data will be used to predict the presence or absence and severity of chemotherapy-induced diarrhea. Microbiome and diet based predictions from blinded samples will be combined to map the diet-microbiome changes during treatment to the changes in immune markers and risk of chemotherapy-induced diarrhea.
Eligibility Criteria
Inclusion Criteria:
Colon cancer diagnosis
Age >18 and < or equal to 79.
Ability to perform informed consent
FOLFOX treatment expected
Exclusion Criteria:
Not Pregnant
Does not have Lynch syndrome or FAP diagnosis.
Inability to perform inform consent
inability to comply with follow up program
history of prior colon cancer diagnosis
previous treatment with antibiotics in the last month.
previous bowel resection.
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There is 1 Location for this study
Temple Texas, 76508, United States More Info
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