Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Inclusion Criteria:

Age ≥18 years
Histologically confirmed stage I, II, or III colon or rectal cancer
Completed surgical resection with curative intent
Completed other cancer-directed treatments
Engage in <150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
No planned major surgery during the study period
Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
Ability to provide written informed consent
Provide written approval by a qualified healthcare professional
Willing to be randomized

Exclusion Criteria:

Evidence of metastatic or recurrent colorectal cancer
Concurrently actively treated other (non-colorectal) cancer
Scheduled to receive other postoperative cancer-directed treatment(s)
Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
Currently participating in another study with competing outcomes
Contraindications to magnetic resonance imaging
Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol